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CHARMs: A new hope for prion disease therapy

Drug development is typically slow: the pipeline from basic research discoveries that provide the basis for a new drug to clinical trials to production of a widely available medicine can take decades.

27 Jun 2024

Study identifies mechanism that impedes the effectiveness of melanoma therapies

In many cases of malignant melanoma, the effect of targeted treatment is lost over time. A research team from UZH and USZ has now discovered that a factor secreted by tumor cells is responsible for the resistance.

27 Jun 2024

MICROBIOMES4SOY: Harnessing microbiome innovations for sustainable food systems

MICROBIOMES4SOY responds to the urgent call on World Microbiome Day to transition to healthier, more environmentally friendly, plant-based diets.

27 Jun 2024

Math model suggests single-parent nursing evolved to fight off bad bacteria

Being nursed by a single parent could be an evolutionary strategy to curb the spread of harmful microbes in mammals, according to a novel theory developed by mathematicians.

27 Jun 2024

Labconco® introduces the Lyph-Seal™ Tray Dryer: Revolutionizing sample preservation

Labconco Corporation is excited to announce the launch of the Lyph-Seal™ Tray Dryer.

From Labconco 27 Jun 2024

Study identifies key neurons controlling threat response and escape in mice

Neuroscientists have discovered how the brain bidirectionally controls sensitivity to threats to initiate and complete escape behaviour in mice. These findings could help unlock new directions for discovering therapies for anxiety and post-traumatic stress disorder (PTSD).

27 Jun 2024

Cell division's hidden safety mechanism may influence cancer growth

Before a cell commits fully to the process of dividing itself into two new cells, it may ensure the appropriateness of its commitment by staying for many hours-;sometimes more than a day-;in a reversible intermediate state, according to a discovery by researchers at Weill Cornell Medicine. Their revelation of this fundamental feature of biology includes details of its mechanisms and dynamics, which may inform the development of future therapies targeting cancers and other diseases.

27 Jun 2024

New insights into early-phase sweat evaporation

Excessive heat across the United States is making this summer a season of sweat. Perspiration and its evaporation are crucial to keeping us cool when things get hot.

26 Jun 2024

Novel approach can make many more bacteria amenable to genetic engineering

Bacteria possess unique traits with great potential for benefiting society. However, current genetic engineering methods to harness these advantages are limited to a small fraction of bacterial species.

26 Jun 2024

CSF1R marker enables study of Macrophage Activation Mosaicism

Macrophages play a critical role in the immune system by fighting infections and aiding in tissue repair.

26 Jun 2024

ELRIG UK and The Protein Society Partner to advance protein sciences in drug discovery

Partners to host joint conference on ‘Protein Sciences in Drug Discovery’ in Cambridge, UK from 18–19 November 2024.

From ELRIG (UK) Ltd. 26 Jun 2024

Dietary fiber promotes beneficial conversion of tryptophan by gut bacteria

We get healthy dietary fibres from consuming fruits, vegetables, and whole grains. But why are the fibres so good for us? A team of researchers has discovered that dietary fibres play a crucial role in determining the balance between the production of healthy and harmful substances by influencing the behavior of bacteria in the colon.

26 Jun 2024

Study provides resource for investigating diabetes-linked transcription factors

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells. Published in the journal Nature Communications, the study revealed common and tissue-specific molecular pathways regulated by HNF4A and HNF1A, two proteins that possess important functions governing the development and function of the pancreas and liver.

26 Jun 2024

Designing hybrid antibodies with enhanced mobility and signaling capacity

Antibodies are the body's superheroes, recognizing and eliminating disease-causing substances.

25 Jun 2024

Association of HLA-G*0104N allele with increased risk of recurrent pregnancy loss in Kashmiri population

HLA-G gene harbors certain polymorphic variations that can potentially impact its biological activity, and therefore, may confer a risk for recurrent pregnancy loss (RPL).

25 Jun 2024

Genetic variation in people of African ancestry linked to increased risk of diabetes complications

A genetic variation common in people of African ancestry is associated with an increased risk of complications from diabetes, including diabetic retinopathy, according to a report published June 25 in the journal Nature Medicine.

25 Jun 2024

Novel genetic predisposition to being overweight or obese identified

Researchers performed a case-control study to compare metabolic changes between individuals homozygous for a loss-of-function genetic variation in small integral membrane protein 1 (SMIM1) and the general population.

25 Jun 2024

Chimpanzees seek out tree bark and ferns with medicinal benefits, researchers discover

Researchers investigated the behavioral and pharmacological effects of self-medicative plants in the diets of Budongo chimpanzees.

25 Jun 2024

New enzyme targets hold promise for cancer therapies

Researchers at Baylor College of Medicine and collaborating institutions have uncovered new potential therapeutic targets for cancer and new insights into existing cancer drug targets, expanding the breadth of possibilities for treating this disease. Using a comprehensive approach that included integrating proteomics, genomics and epigenomics data from 10 cancer types, the team identified protein and small protein or peptide targets in cancer tissues and validated many of them experimentally as promising candidates for therapeutic strategies. The study appeared in Cell.

25 Jun 2024

Study links gene regulation to allergic airway inflammation

Asthma patients experience respiratory distress due to allergens like house dust mites or pollen. However, the various triggers for asthma share a common pathway involving the release of proteins called type-2 cytokines by Type-2 helper T (Th2) cells and group-2 innate lymphoid cells (ILC2s). Both Th2 and ILC2 require high amounts of GATA-binding protein 3 (GATA3) for their maturation.

25 Jun 2024