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Primitive endoderm in early embryos may be key to creating new effective fertility treatments

An unexpectedly versatile and regenerative stem cell in early embryos may be key to creating new effective fertility treatments, suggests a new study in mice from the University of Copenhagen.

24 Jun 2024

KU researchers uncover role of Src gene in nervous system development

Many people are familiar with oncogenes -; genes long known to be involved in cancers in humans, such as the gene "Src."

24 Jun 2024

Using microbial community-scale metabolic modeling approach for precision nutrition

Short-chain fatty acids (SCFAs) are beneficial molecules created by the bacteria residing in our gut that are closely tied to improved host metabolism, lower systemic inflammation, better cardiovascular health, lower cancer risk, and more.

24 Jun 2024

DiffPALM: Advancing protein interaction prediction with AI and language models

Proteins are the building blocks of life, involved in virtually every biological process. Understanding how proteins interact with each other is crucial for deciphering the complexities of cellular functions, and has significant implications for drug development and the treatment of diseases.

24 Jun 2024

Advances in Diels-Alder synthesis of hydrocarbazole compounds using lanthanide catalysts

Hydrocarbazole is a crucial compound in organic chemistry, serving as a building block for various biologically active compounds, including pesticides like strychnine and anticancer drugs such as vinblastine and minovincine.

24 Jun 2024

Antisense RNA acts as a cellular 'booster' for gene expression, study finds

The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins – yet it exists in large quantities.

24 Jun 2024

Innovative SRPFM technique enables ultra-sensitive force measurement at nanoscale in fluids

Groundbreaking research has revealed a new way to measure incredibly minute forces at the nanoscale in water, pushing the boundaries of what scientists know about the microscopic world.

24 Jun 2024

Dietary sucrose modulates lithium's regulatory activity in Drosophila

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 11, entitled, "Dietary sucrose determines the regulatory activity of lithium on gene expression and lifespan in Drosophila melanogaster."

24 Jun 2024

New study warns of potential pandemic risk from α-H1N2 swine flu virus

The α-H1N2 influenza virus in swine poses a higher pandemic risk due to its ability to evade human immunity and transmit between species, highlighting the need for vigilant monitoring.

23 Jun 2024

Hematopoietic stem cells in the bone marrow age differently in genetically identical mice

Our bone marrow-;the fatty, jelly-like substance inside our bones-;is an unseen powerhouse quietly producing 500 billion new blood cells every day.

21 Jun 2024

How random gene activity shapes lifespan in C. elegans

Why do some people live for longer than others? The genes in our DNA sequence are important, helping avoid disease or maintain general health, but differences in our genome sequence alone explain less than 30% of the natural variance of human life expectancy.

21 Jun 2024

Restoring youthful TERT levels reverses aging phenotypes in preclinical models

Researchers at The University of Texas MD Anderson Cancer Center have demonstrated that therapeutically restoring 'youthful' levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical models.

21 Jun 2024

Transforming drug discovery with AI

A new AI-powered program will allow researchers to level up their drug discovery efforts.

21 Jun 2024

Insilico Medicine leadership team shares insights on AI-powered healthcare innovation

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, announces that the co-CEOs of the company – Alex Zhavoronkov, PhD, and Feng Ren, PhD – will be attending the 15th Annual Meeting of the New Champions, also known as Summer Davos hosted by the World Economic Forum, in Dalian, China, from 25 to 27 June 2024.

21 Jun 2024

Decoding broccoli’s genome: Advances in glucosinolate biosynthesis and health benefits

A detailed genomic study of broccoli has revealed the genetic foundations for the production of glucosinolates (GSLs), compounds celebrated for their health benefits, including anti-carcinogenic properties.

21 Jun 2024

Study links lifetime cannabis use with substance use, mood disorders, celiac, and infectious diseases

Researchers identify genetic loci associated with lifetime and frequency of cannabis use.

21 Jun 2024

Using deep learning to design synthetic soluble versions of cell membrane proteins

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior.

21 Jun 2024

Artificial variants of Withanolides act highly specifically against leukemia cells

Nightshade plants produce a diverse array of compounds with therapeutic potential. Researchers at CeMM have now identified an artificial variant inspired by the Withanolides group that acts highly specifically against leukemia cells.

21 Jun 2024

Advances in organoids and embryonic models pose no risk to personhood, expert argues

Advances in organoids and embryonic models of human development have the potential to prompt social and existential questions-;e.g., what defines human individuality? However, bioethicist Insoo Hyun of Harvard Medical School and the Museum of Science in Boston says that these models have the potential to strengthen rather than weaken the concept of human individuality when considered within the philosophical frameworks of "personhood" and sentience.

20 Jun 2024

Breakthrough in enzyme communication could pave the way for new drugs

A mechanism that could help scientists harness enzymes for use in drug discovery has been discovered in a research breakthrough at the University of Birmingham.

20 Jun 2024

Life Science News

Primitive endoderm in early embryos may be key to creating new effective fertility treatments

KU researchers uncover role of Src gene in nervous system development

Using microbial community-scale metabolic modeling approach for precision nutrition

DiffPALM: Advancing protein interaction prediction with AI and language models

Advances in Diels-Alder synthesis of hydrocarbazole compounds using lanthanide catalysts

Antisense RNA acts as a cellular 'booster' for gene expression, study finds

Innovative SRPFM technique enables ultra-sensitive force measurement at nanoscale in fluids

Dietary sucrose modulates lithium's regulatory activity in Drosophila

New study warns of potential pandemic risk from α-H1N2 swine flu virus

Hematopoietic stem cells in the bone marrow age differently in genetically identical mice

How random gene activity shapes lifespan in C. elegans

Restoring youthful TERT levels reverses aging phenotypes in preclinical models

Transforming drug discovery with AI

Insilico Medicine leadership team shares insights on AI-powered healthcare innovation

Decoding broccoli’s genome: Advances in glucosinolate biosynthesis and health benefits

Study links lifetime cannabis use with substance use, mood disorders, celiac, and infectious diseases

Using deep learning to design synthetic soluble versions of cell membrane proteins

Artificial variants of Withanolides act highly specifically against leukemia cells

Advances in organoids and embryonic models pose no risk to personhood, expert argues

Breakthrough in enzyme communication could pave the way for new drugs

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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