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Genetic mutation in OXR1 gene linked to brain development issues

Study investigates the effects of a loss-of-function mutation in the OXR1 gene on neurodevelopment and cellular functions in the human brain. The research shows that OXR1 deficiency impairs neural differentiation, increases sensitivity to oxidative stress, and alters histone methylation, impacting brain development and potentially contributing to neurological disorders.

27 Nov 2023

Synthetic biologists develop versatile platform for targeted drug delivery

In recent years, cell and gene therapies have shown significant promise for treating cancer, cystic fibrosis, diabetes, heart disease, HIV/AIDS and other difficult-to-treat diseases.

27 Nov 2023

New CRISPR approach shows promise for treating glioblastoma

The gene-editing technology CRISPR shows early promise as a therapeutic strategy for the aggressive and difficult-to-treat brain cancer known as primary glioblastoma, according to findings of a new study from Gladstone Institutes.

27 Nov 2023

Infant face preference linked to genetics

Whether infants at five months of age look mostly at faces or non-social objects such as cars or mobile phones is largely determined by genes.

27 Nov 2023

Genome haplarithmisis sheds light on complex genetic landscape of miscarriages

A new study published in Nature Medicine reports on a chromosomal analysis of over 1,700 spontaneous early miscarriages.

27 Nov 2023

Scientists discover master regulator gene for fat storage

We all know that weight gain and weight loss are not as simple as "calories in, calories out," given that countless factors affect body weight.

27 Nov 2023

Scientists succeed in mapping a central part of the immune system

A new paper in Science Advances details how scientists have succeeded in mapping a central part of the immune system - the HLA class II molecules - while accurately predicting how they display fragments of pathogens on the surface of cells.

24 Nov 2023

Unveiling the role of Daam1 gene in intestinal stem cell fate decisions

Stem cells can differentiate to replace dead and damaged cells. But how do stem cells decide which type of cell to become in a given situation?

24 Nov 2023

Heat shock protein protects bacteria from plasma treatment

A heat shock protein protects the cells against protein clumping. It degrades, however, over longer treatment periods.

24 Nov 2023

Parkinson's disease a potential pathogenetic factor for coronary artery disease and stroke, study suggests

Researchers performed a two-sample Mendelian randomization (MR) analysis to explore causal associations between Parkinson's disease (PD) and cardio-cerebrovascular diseases.

24 Nov 2023

Genome study unveils genetic ties between cannabis use disorder and lung cancer risk

A genome-wide association study in Nature Genetics reveals insights into the genetics of cannabis use disorder, highlighting its strong association with psychopathology and a causal link to lung cancer, and suggesting distinct genetic pathways from mere cannabis use.

23 Nov 2023

New AI approach captures the tempo and stages of embryonic development

Animal embryos go through a series of characteristic developmental stages on their journey from a fertilized egg cell to a functional organism.

23 Nov 2023

Breakthrough decoding of the Y chromosome revolutionizes digestive disease research

A major breakthrough in human genetics has been achieved with the complete decoding of the human Y chromosome, opening up new avenues for research into digestive diseases.

23 Nov 2023

JMU Würzburg professor wins ERC Consolidator Grant to advance research on ferroptosis

With the coveted Consolidator Grants totalling two million euros, the European Research Council (ERC) supports outstanding scientists whose work promises further top achievements. José Pedro Friedmann Angeli, Professor of Translational Cell Biology at Rudolf Virchow Centre - Centre for Integrative and Translational Bioimaging at Julius-Maximilians-Universität (JMU) Würzburg, now belongs to this group.

23 Nov 2023

Plant proteins found to mimic human immune signaling proteins

Researchers have shown that certain plant proteins resemble human signaling proteins of the immune system and can bind to their receptors.

23 Nov 2023

Saliva substitute from University of Leeds scientists offers major relief for dry mouth conditions

Researchers compared the in vitro lubrication performance of a patented microgel-based aqueous hydrogel lubricant formulation in its dairy and vegan formulation to that of various commercially available saliva substitutes, classified into "liquids," "viscous liquids," and "gels" based on shear rheology and extensional properties.

23 Nov 2023

Naked clams – tomorrow's answer for a more sustainable food source?

Researchers evaluated teredinids as a potentially nutritious and sustainable future food source.

23 Nov 2023

Non-invasive genetic test for fetal DNA sequencing developed

A team of investigators from Massachusetts General Hospital (MGH), Brigham and Women's Hospital (BWH), and the Broad Institute of MIT and Harvard have developed a non-invasive genetic test that can screen the blood of pregnant individuals to survey all genes for fetal DNA sequence variants.

22 Nov 2023

Study identifies common skin bacterium as previously unknown culprit behind itch

Scientists at Harvard Medical School have shown for the first time that a common skin bacterium -; Staphylococcus aureus -; can cause itch by acting directly on nerve cells.

22 Nov 2023

Antibiotics that target mitochondria may promote longevity

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 21, entitled, "Antibiotics that target mitochondria extend lifespan in C. elegans."

22 Nov 2023