Life Science White Papers

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Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in life science research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

Using X-CLARITY™ Mounting Solution for Efficient RI Matching of Cleared and Immunolabeled Tissues

The X-CLARITY™ Tissue Clearing System is a cutting edge advancement in the field of biomedical research, transforming biological tissue into a state transparent to light. This system removes lipids electrophoretically from the tissue-hydrogel hybrids. Lipids are fat molecules that are the main component of light scattering in biological tissues.

From Logos Biosystems 3 Jun 2016

Evaluation of Mixing Performance of Vitl Co-Mix Laboratory Mixer with High Viscosity Solutions

An orbital mixer’s efficiency is significantly affected by the viscosity of a solution. Commonly used non-aqueous mixing solvents for dyes, vaccines, and drugs are viscous liquids such as glycerol and polyethylene-glycol (PEG). These liquids are also used in protein solutions as stabilizing agents. The performance of a Vitl Co-Mix in mixing solutions containing a higher proportion of glycerol in various tubes and microplates was evaluated in this study.

From Vitl Life Science Solutions 29 Apr 2016

Vitl’s Bespoke Lab Equipment Solutions Optimize Customer Methods

Since Vitl was established as an engineering company, it can produce custom-made lab products and software that are optimized for users’ methods. This article provides a few examples of how Vitl has customized its lab products in the past.

From Vitl Life Science Solutions 29 Apr 2016

Medway School of Pharmacy Team Reproducibly Produces and Tests Nanomaterials Using Vitl's Mixers

Nanoparticles are tiny delivery vehicles that can travel to regions where no drugs have gone before and provide the treatment at the right dose and time, with little to no side-effects. They have long been considered as having the potential to transform the future of medicine. In this article, Dr Vladimir Gubala, lecturer in Chemistry and Drug Delivery at the Medway School of Pharmacy, describes the challenges and benefits of using Vitl's Co-Mix.

From Vitl Life Science Solutions 26 Apr 2016

History and Product Range of Vitl Life Science Solutions

Vitl is a brand within the Integrated Technologies Ltd (ITL) group, which is a global product development and manufacturing company. The group has more than four decades of experience in instrument design and manufacturing projects, targeting medical devices, in vitro diagnostics (IVD), and laboratory equipment. The dedicated development team consists of ex-ITL engineers who have developed all Vitl products using this experience. This article discusses the team’s main milestones.

From Vitl Life Science Solutions 26 Apr 2016

Quantitative Measurement of Active Neutrophil Elastase Levels Using ProteaseTag™ Active NE Immunoassay

Lung function may be affected due to cycles of prolonged inflammation as well as chronic infection of the airways that lead to respiratory diseases.

From BMG LABTECH GmbH 18 Apr 2016

Flexible Technology Accelerates Diagnosis of Prostate Cancer

Prostate cancer is a common malignant disease seen in men, which accounts for almost one-third every year of all the new diagnoses made for cancer.

From Huron Digital Pathology 23 Mar 2016

Intracytoplasmic Sperm Injection Using Eppendorf Transferman® 4m Micromanipulator

Studies on assisted fertilization via micromanipulation techniques have gradually evolved from 1988 to the present day. The technique of intracytoplasmic sperm injection or ICSI (Figure 1) is a great benefit in providing treatment for infertile couples, especially those patients with male factor.

From Eppendorf 21 Mar 2016

Eppendorf TransferMan® 4r – All-Encompassing Manipulator for Genetic Engineering Techniques

The modification of laboratory animal genomes is carried out by micromanipulation of embryos or oocytes. The usual techniques of micromanipulation are: transcription activator-like effector nuclease (TALEN) into the cytoplasm into a pronucleus of early zygotes; or microinjection of nucleic acid constructs like larger bacterial artificial chromosomes (BAC), simple transgenes, and zinc finger (ZFN).

From Eppendorf 21 Mar 2016

Ramp Rate Data Alone Not Enough for Evaluation of PCR Thermal Cyclers

In order to compare various thermal cycler speeds, it is not enough to take into account only the heating ramp rate and cooling ramp rate available in the technical specifications, as these data do not give a picture of the actual run times.

From Eppendorf 21 Mar 2016

Dual Block Thermocycler Mastercycler® nexus GX2 Allows PCR Optimization, Offers High Flexibility

Flexible application options are essential for optimal utilization of laboratory instruments in many laboratories. In those laboratories where more than one user is dependent on a single instrument, flexible operation can result in usage frequency.

From Eppendorf 21 Mar 2016

Novel Use of EPR Spectroscopy to Study In Vivo Protein Structure

α-synuclein is a protein found abundantly throughout the brain. It is present mainly at the neuron ends where it is thought to play a role in ensuring the supply of synaptic vesicles in presynaptic terminals, which are required for the release of neurotransmitters to relay signals between neurons. It is critical for normal brain function.

From Bruker BioSpin - NMR, EPR and Imaging 15 Mar 2016

Using Real-Time Infrared Chemical Imaging in Mass Spectrometry Tissue Analysis

Mass spectrometry (MS) is an analytical technique, which can be employed in studies involving the determination of the composition of complex biochemical samples.

From Daylight Solutions Inc 14 Mar 2016

PHERAstar® FSX Plate Reader Helps Improve Throughput of Screening Facilities

Screening facilities need to take necessary measures continuously for increased throughput, reduced sample expenditure and better control over cost.

From BMG LABTECH GmbH 22 Feb 2016

Using Secondary UV-VIS Filter Set to Evaluate the Functionality of Eppendorf BioPhotometer® and BioSpectrometer®

Whenever a sample is measured, the quality of the reading cannot exceed that of the measurement. Thus, it is vital to have a control on the sources of error that negatively impact the measurement or maintain them within defined limits. Errors can have technical causes or may be caused due to improper handling. Incorrect handling errors for photometric quantification includes sample concentration being too high or too low, wrongly programmed method factor, or insufficient sample mixing.

From Eppendorf 18 Feb 2016

Using Eppendorf BioSpectrometer for the determination of enzyme activity and substrate concentration

This article shows how enzymatic activity can be effectively determined by means of the Eppendorf BioSpectrometer. The preliminary measurements were carried out by utilizing the “single λ-continuous” method for optimized measurement process. Based on these outcomes, the exact measurements of the enzyme activity were carried out. Linear regression was used to measure enzyme activities.

From Eppendorf 18 Feb 2016

Troubleshooting Guide for the Determination of Nucleic Acids Using Eppendorf BioPhotometer® D30 and Eppendorf BioSpectrometer®

This guide on troubleshooting will enable users to get reliable results when quantifying nucleic acids through various devices available in the Eppendorf photometer series (Figure 1). Therefore, the important factors which help to attain accurate measurements and problem-solving recommendations are given below. Figure 1 shows a pictorial example of Eppendorf BioPhotometer® D30.

From Eppendorf 18 Feb 2016

Standard Curve Generation for Colorimetric Assay in the Kinetic or Basic Eppendorf BioSpectrometer®

This article shows how the absorbance maxima of Ponceau-S is determined over a wavelength range of 220nm to 800nm using the Eppendorf BioSpectromenter®. The methods of analysis using this BioSpectrometer® are the detection of a maximum at 498nm while utilizing the function, Eppendorf “SpectraZoom”. Using the example of Ponceau-S, the colorimetric measurements were done by generating a standard curve. This standard programmed curve was then utilized to measure the concentration of unknown sample.

From Eppendorf 18 Feb 2016

The PROFILE NMR Technique to Characterize Monoclonal Antibodies

Monoclonal antibodies (MAbs) are an important class of drugs. They have the ability to recognize and bind to almost any molecular structure, giving them incredible potential in drug development. MAbs are primarily used in cancer, inflammatory diseases and infection, and currently represent the largest and fastest growing sector of biologic pharmaceuticals.

From Bruker BioSpin - NMR, EPR and Imaging 16 Feb 2016

Advances in 2D NMR Spectroscopy of Monoclonal Antibodies

Monoclonal antibodies (mAbs) represent one of the fastest growing classes of pharmaceuticals, and look set to be the focus of the biotherapeutics industry into the years to come.

From Bruker BioSpin - NMR, EPR and Imaging 9 Feb 2016

Life Science White Papers

Using X-CLARITY™ Mounting Solution for Efficient RI Matching of Cleared and Immunolabeled Tissues

Evaluation of Mixing Performance of Vitl Co-Mix Laboratory Mixer with High Viscosity Solutions

Vitl’s Bespoke Lab Equipment Solutions Optimize Customer Methods

Medway School of Pharmacy Team Reproducibly Produces and Tests Nanomaterials Using Vitl's Mixers

History and Product Range of Vitl Life Science Solutions

Quantitative Measurement of Active Neutrophil Elastase Levels Using ProteaseTag™ Active NE Immunoassay

Flexible Technology Accelerates Diagnosis of Prostate Cancer

Intracytoplasmic Sperm Injection Using Eppendorf Transferman® 4m Micromanipulator

Eppendorf TransferMan® 4r – All-Encompassing Manipulator for Genetic Engineering Techniques

Ramp Rate Data Alone Not Enough for Evaluation of PCR Thermal Cyclers

Dual Block Thermocycler Mastercycler® nexus GX2 Allows PCR Optimization, Offers High Flexibility

Novel Use of EPR Spectroscopy to Study In Vivo Protein Structure

Using Real-Time Infrared Chemical Imaging in Mass Spectrometry Tissue Analysis

PHERAstar® FSX Plate Reader Helps Improve Throughput of Screening Facilities

Using Secondary UV-VIS Filter Set to Evaluate the Functionality of Eppendorf BioPhotometer® and BioSpectrometer®

Using Eppendorf BioSpectrometer for the determination of enzyme activity and substrate concentration

Troubleshooting Guide for the Determination of Nucleic Acids Using Eppendorf BioPhotometer® D30 and Eppendorf BioSpectrometer®

Standard Curve Generation for Colorimetric Assay in the Kinetic or Basic Eppendorf BioSpectrometer®

The PROFILE NMR Technique to Characterize Monoclonal Antibodies

Advances in 2D NMR Spectroscopy of Monoclonal Antibodies

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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