Life Science White Papers

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Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in life science research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

Microspheres in Biomedical Applications

Biomedical applications of microspheres in drug delivery and bone tissue engineering offer many advantages over other particle geometries.

From SpringerOpen 4 Aug 2016

Protein Allostery and NMR

Allostery – the phenomenon by which an event in one part of a molecule causes an effect in another – is a key feature of protein regulation in all living cells. Rather than directly affecting a protein’s active site, allostery can modulate the active state of a protein through ligand binding, covalent modification or mutation elsewhere in the protein.

From Bruker BioSpin - NMR, EPR and Imaging 3 Aug 2016

Pushing the Limits of Light - Super Resolution Imaging

Since its inception in the late sixteenth century, light microscopy has provided biologists with ever increasing knowledge about microorganisms and the world beyond the scope of the human eye.

From Bruker Nano Surfaces and Metrology 25 Jul 2016

Using Isothermal Titration Calorimetry Technique for Structural Studies

Complexes, such as protein/protein, nucleic acids/nucleic acid, protein/nucleic acid, protein/ligand, nucleic acid/ligand, are often difficult to crystallize even on well-defined biological systems, consuming more time and amount of the sample.

From Malvern Panalytical 25 Jul 2016

Everstill™ Technology: Active Vibration Cancellation Platform for Safe Micromanipulation

Contemporary technology and equipment, originally designed in the late 1970s, have given way to more sophisticated methods and more flourishing protocols. In vitro fertilization, popularly known as IVF, is a unique kind of assisted reproductive technology (ART).

From TMC Vibration Control 21 Jun 2016

Using NIR Spectroscopy to Detect the Water Content of Soft Contact Lenses

Soft contact lenses are known to be extremely delicate.

From Metrohm USA Inc. 20 Jun 2016

Using In-Line and Off-Line NIR Methodologies for Real-Time Predictions of Moisture Content and Particle Size in Fluid Bed Granulation

The pharmaceutical industry often uses a process called fluid bed granulation to create solid dosage forms.

From Metrohm USA Inc. 20 Jun 2016

Using IC-ICP/MS Analysis to Discover Effectiveness of Ozonization of Iodinated X-ray Contrast Media

Targeted imaging of organs can distinguish healthy from unhealthy tissues when contrast media are used in non-invasive diagnostics, such as X-ray and MRI.

From Metrohm USA Inc. 20 Jun 2016

Quality Monitoring of Radiopharmaceuticals with Ion Chromatographs from Metrohm

Diseases are diagnosed, treated and prevented with nuclear medicine using radioactive substances called radiopharmaceuticals.

From Metrohm USA Inc. 20 Jun 2016

Using FTIR Spectroscopy to Determine Protein Secondary Structure

Proteins are the basic building blocks of life. They play a critical role in cell function and structure and are involved in transport, communication and metabolism in the body.

From Specac Ltd 20 Jun 2016

Metrohm’s Fully Automated Method for Determination of Water Content in Tablets

The release rate and the shelf life of active substances present in tablets are influenced by their water content.

From Metrohm USA Inc. 16 Jun 2016

Ion Chromatography – A Universal Technique with Many Applications in the Pharmaceutical Industry

Maintaining high levels of drug quality and safety is priority for the pharmaceutical industry.

From Metrohm USA Inc. 16 Jun 2016

Advantages and Disadvantages of Native and Cross-Linked Chromatin Immunoprecipitation

Two major options are available that can be used for preparing chromatin during the chromatin immunoprecipitation (ChIP) process. These include using a chemical agent like formaldehyde (X-ChIP) to crosslink the chromatin, or using native ChIP (N-ChIP) for non-cross linking the chromatin.

From Chromatrap® - Porvair Sciences Ltd 16 Jun 2016

Triple Detection Size Exclusion Chromatography (SEC-TD) Analysis of Protein-Protein Interactions

The biological function of proteins relies on their ability to form structured, ordered complexes such as homo-oligomers or hetero-oligomers. Attributes such as stability, activity, and localization can be controlled by these complexes.

From Malvern Panalytical 15 Jun 2016

Particle Analysis of Small Sample Volumes Using Hydro SV

Most of the time, only minimal volumes of the sample are available for particle size analysis. Typically, in catalysis and pharmaceutical industries, particle size analysis needs to be conducted at initial stages of product development, when the available quantity of the material to be analyzed is only a few milligrams. In such cases, reliable measurements on minute sample volumes are required, and the sample needs to be retrieved for further analysis.

From Malvern Panalytical 15 Jun 2016

Investigation of MRT Contrast Media Containing Gadolinium by Means of IC-ICP/MS Analysis

Healthy and diseased tissues can be distinguished with highly detailed image of the organ provided by non-invasive diagnostics that make use of contrast agents.

From Metrohm USA Inc. 8 Jun 2016

Content Determination of Amino Acids Using Ion Chromatography

There are currently 22 amino acids determined as protein building blocks.

From Metrohm USA Inc. 8 Jun 2016

Applications of Nanoparticle Tracking Analysis in Nanomedicine

Nanoparticles are increasingly being used in a wide range of sectors. This article evaluates particular mechanisms through which nanoparticles are uniquely developed and formulated. It also discusses the important role of nanoparticle tracking analysis (NTA) in the field of nanomedicine.

From Malvern Panalytical 6 Jun 2016

Applications of Nanoparticle Tracking Analysis in Drug and Gene Delivery

Nanoparticle tracking analysis (NTA) is a unique method that provides fast and multi-parameter information about nanoparticles. With the help of this technique, users can acquire number frequency distributions of particle sizes in polydisperse nanoparticulate systems.

From Malvern Panalytical 6 Jun 2016

LUNA-II™: An Automated Cell Counter with High Accuracy and Low Variability

In the field of biomedical research, accurate counting of cells is extremely important for ensuring both inter- and intra-lab reproducibility. Inaccurate cell counts have a negative impact not only on the reproducibility, but also on the potency and/or efficacy of cell therapy, disease diagnosis, the growth rate of regenerated tissues and various bioassays.

From Logos Biosystems 3 Jun 2016