Life Science White Papers

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Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in life science research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

Determining Permeability of Intestine Lactulose and Mannitol by Ion Chromatography with Pulsed Amperometric Detection

The use of ion chromatography with amperometric detection for simple and reliable determination of lactulose and mannitol in urine is described in this article.

From Metrohm USA Inc. 10 Dec 2015

Stabilizing Lipid Bilayer Membranes

Ion channels are essential to key cellular processes including signal transduction, osmoregulation and maintenance of the membrane potential. They are therefore the targets of many clinically used drugs.

From Pittcon 9 Dec 2015

Accurate Detection of API Release from Sustained-Release Tablets Using Near-Infrared Spectroscopy

Numerous therapeutic advantages are offered by sustained-release drugs, which release active pharmaceutical ingredients (APIs) in a gradual manner.

From Metrohm USA Inc. 8 Dec 2015

Stimulated Raman Scattering (SRS) Microscopy and Cancer Detection

The ability to distinguish cancer cells from healthy cells during surgery is essential for preventing the removal of healthy tissue and ensuring no tumor remnants are left behind.

From Pittcon 24 Nov 2015

Using the Eppendorf BioSpectrometer® Fluorescence for Evaluating RNA Quantification Kits

UV-VIS spectrometers are commonly used for determining the concentration of nucleic acids through light absorption measurements. The absorbance measurements are carried out at 260nm, and a conversion factor specific to the sample is used for calculating the concentration.

From Eppendorf 20 Nov 2015

Highly Precise Photometric Measurements of Nucleic Acids or Proteins using Eppendorf µCuvette™ G1.0

A necessary step in the preparation of biomolecules for downstream applications is determining their concentration by photometric methods, once the nucleic acids or proteins are isolated.

From Eppendorf 20 Nov 2015

Using Eppendorf BioSpectrometer® Fluorescence for Nucleic Acid Concentration Measurements

Quantification of nucleic acid concentrations is often performed by measuring light absorption in UV-VIS spectrometers. There are a few challenges faced in this measurement method.

From Eppendorf 19 Nov 2015

Simplifying Drug Evaluation with the mobilePDR App

Making the best treatment decision for each patient can be a daunting task for healthcare professionals. As of 2013, there were 1453 molecular entities approved by the FDA for use in the United States, in addition to the new medications introduced each year and the extensive range of over-the-counter drugs.

From Physicians' Desk Reference (PDR) 19 Nov 2015

Understanding Alzheimer’s Disease Through Genomics and Proteomics

Alzheimer’s disease is a progressive neurodegenerative condition that causes dementia. In this disease, dementia symptoms such as memory loss and difficulties with language, problem-solving and reasoning gradually worsen until they eventually start to interfere with everyday life and basic tasks such as eating and drinking.

From Pittcon 11 Nov 2015

The Bedbug Aggregation Pheromone and NMR Spectroscopy: An Overview

Bedbugs are small, flat, parasitic insects that bite the skin of sleeping humans or animals in order to feed on their blood.

From Bruker BioSpin - NMR, EPR and Imaging 10 Nov 2015

Using the mobilePDR App to Search Drugs and Interactions

Generations of healthcare professionals have trusted the Physicians’ Desk Reference (PDR) for the most current knowledge about drug prescribing information to support prescribing decisions and improve patient medication adherence, with the goal of improving health outcomes.

From Physicians' Desk Reference (PDR) 5 Nov 2015

Using Morphologi G3-ID to Characterize Protein Aggregates in Stressed Lysozyme Sample

Biotherapeutic formulations have been characterizing particles through optical microscopy for a long time. The obtained shape, size, and transparency characteristics are used to categorize particulates into distinct classes, such as sundry contaminants, silicone oil and aggregates.

From Malvern Panalytical 5 Nov 2015

Using CLARIOstar and PHERAstar FS to Monitor Ligand Binding to GPCRs in Live Cells with NanoBRET Assay

GPCRs remain the subject of intense research in the pharma and medical fields as they play a key role in transmitting cellular responses to external stimuli.

From BMG LABTECH GmbH 27 Oct 2015

Detection and Quantification of Tau Aggregates in Brain Tissue

The structures of the human brain are stabilized by tau protein and will be collapsed in the presence of abnormal tau protein, leading to plaque development.

From BMG LABTECH GmbH 27 Oct 2015

Using Mass Spectrometry to Detect Food Allergens

Food allergies are a major public health concern and are increasing worldwide. Globally, it is thought that between 220 and 250 million people suffer from a food allergy. Ninety percent of cases involve sensitivity to one of the 'Big Eight' allergens: egg, fish, milk, peanut, shellfish, soy, tree nuts, or wheat.

From Pittcon 27 Oct 2015

Ensuring Optimum Product and Operator Safety in Production of Highly Potent Drugs with Hosokawa Micron’s Containment Solutions

Hosokawa Micron offers a range of novel technologies for use in primary and secondary pharmaceutical production of active pharmaceutical ingredients and intermediates to respiratory drugs, vitamins and food supplements. The technology and skills delivered by Hosokawa Micron range from lab and pilot plant through to full manufacture, offering straight forward and practical solutions to meet complex production requirements.

From Hosokawa Micron Ltd 22 Oct 2015

Hosokawa Micron’s Integrated Batch Milling and Packing System for Processing HAPI Materials

As the demand for more effective drugs increases, so does the potency of the drugs being developed. Safeguarding and protecting both products and the operators is vital, as is taking into consideration the need to ensure maximum flexibility in the design of systems for processing highly potent active pharmaceutical ingredients (HAPI).

From Hosokawa Micron Ltd 22 Oct 2015

Major Pharmaceutical Products Manufacturer Upgrades Operation with Hosokawa Micron’s Multi-functional Dispensary Booth

Hosokawa Micron Ltd was approached by a major pharmaceutical products manufacturer wanting a customized, multi-purpose dispensary weigh booth to be developed. The aim was to increase capacity at their Centre of Excellence for tablet manufacturing and packaging, situated in the north of England.

From Hosokawa Micron Ltd 20 Oct 2015

Advances in Contaminant Testing of Dietary Supplements

In the western world, dietary supplements are a billion-dollar industry, with around half of all adults in the United States consuming such products. Many consumers like to buy products marked as herbal or “natural”, often regarding these to be better for them, or even harmless.

From Pittcon 14 Oct 2015

Faster Breath Analysis with MAX300-LG™ Breath Analyzer

The preferred gas analysis technique for most of the respiratory applications is mass spectrometry. MAX300-LG™ allows faster breath analysis that requires only a minimal sample flow.

From Extrel CMS, LLC 14 Oct 2015