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Indevus Pharmaceuticals enters merger agreement with Endo Pharmaceuticals

Indevus Pharmaceuticals, Inc. has announced that it has entered into a definitive merger agreement under which Endo Pharmaceuticals Holdings, Inc.

5 Jan 2009

Debate on treating fevers in African children

A new debate in the open access journal PLoS Medicine questions whether all African children with fever should be treated presumptively with antimalarial drugs, or if treatment should wait until laboratory tests confirm malarial infection.

5 Jan 2009

Metadherin gene plays dual role in breast cancers with poor prognosis

A new study reveals that the metadherin gene (MTDH) plays a role in both cancer metastasis and resistance to chemotherapy.

5 Jan 2009

Antibodies take 'evolutionary leaps' to fight microbes

With cold and flu season in full swing, the fact that viruses and bacteria rapidly evolve is apparent with every sneeze, sniffle, and cough.

5 Jan 2009

Endo Pharmaceuticals to acquire Indevus Pharmaceuticals

Endo Pharmaceuticals (NASDAQ:ENDP) and Indevus Pharmaceuticals, Inc. (NASDAQ: IDEV) announced today that they have entered into a merger agreement under which Endo will commence a tender offer to acquire 100 percent of the outstanding shares of Indevus for approximately $370 million, or $4.50 per Indevus share, in cash, and up to an additional approximately $267 million, or $3.00 per Indevus share, in cash payable in the future upon achievement of certain regulatory and sales milestones.

5 Jan 2009

Cylene Pharmaceuticals starts CX-4945 trial - first-in class inhibitor of CK2

Cylene Pharmaceuticals announced today that it has initiated a Phase I clinical trial of its oral CK2 protein kinase inhibitor, CX-4945, in patients with advanced solid tumors, Castleman's disease, or multiple myeloma.

5 Jan 2009

Collagen VI protects brain cells against amyloid-beta proteins

Scientists from the Gladstone Institute of Neurological Disease (GIND), UCSF, and Stanford have discovered that a certain type of collagen, collagen VI, protects brain cells against amyloid-beta proteins, which are widely thought to cause Alzheimer's disease (AD).

5 Jan 2009

Discovery of new tumor suppressor for lung cancer

Cancer and cell biology experts at the University of Cincinnati (UC) have identified a new tumor suppressor that may help scientists develop more targeted drug therapies to combat lung cancer.

5 Jan 2009

Carotid endarterectomy provides better short-term results than carotid artery stenting in patients with carotid artery disease

Carotid endarterectomy (CEA) yields better short-term results than carotid artery stenting (CAS) in patients with carotid artery disease, according to a 30-day outcomes report from the Society for Vascular Surgery (SVS) Vascular Registry for Carotid Procedures, published in the January 2009 issue of the Journal of Vascular Surgery, by the Society for Vascular Surgery.

5 Jan 2009

Researchers show mechanisms that regulate DNA damage control and replication

Scientists at Burnham Institute for Medical Research (Burnham) have demonstrated important new roles for the protein kinase complex Cdc7/Dbf4 or Cdc7/Drf1 (Ddk) in monitoring damage control during DNA replication and reinitiating replication following DNA repair.

5 Jan 2009

Discovery of 'on switch' for cell death signaling mechanism

Scientists at Burnham Institute for Medical Research (Burnham) have determined the structure of the interactions between proteins that form the heart of the death inducing signaling complex (DISC), which is responsible for triggering apoptosis (programmed cell death).

5 Jan 2009

Frontostriatal brain circuits play role in bulimia nervosa in women

Women with bulimia nervosa appear to respond more impulsively during psychological testing than those without eating disorders, and brain scans show differences in areas responsible for regulating behavior, according to a report in the January issue of Archives of General Psychiatry , one of the JAMA/Archives journals.

5 Jan 2009

Childhood trauma associated with increased risk for chronic fatigue syndrome

Childhood trauma is a potent risk factor for development of chronic fatigue syndrome (CFS), according to a study by researchers at Emory University School of Medicine and the Centers for Disease Control and Prevention (CDC).

5 Jan 2009

PDL BioPharma and Alexion Pharmaceuticals resolve patent dispute

PDL BioPharma, Inc. and Alexion Pharmaceuticals, Inc. today jointly announced that the companies have entered into a definitive license agreement and settlement agreement that resolve the legal disputes between them relating to Alexion's humanized antibody, Soliris (eculizumab) and PDL's patents known as the Queen et al. patents.

5 Jan 2009

Adult-onset diabetes slows mental functioning in several ways, with deficits appearing early

Adults with diabetes experience a slowdown in several types of mental processing, which appears early in the disease and persists into old age, according to new research.

5 Jan 2009

Tips for better eating

Lots of experts disagree over the seemingly obvious notion of keeping weight off by trying to eat less - a debate that centers on whether the practice backfires, leading to binging and weight gain.

5 Jan 2009

Discovery of new syndrome associated with severe congenital neutropenia

A team of scientists has discovered a new syndrome associated with severe congenital neutropenia (SCN), a rare disorder in which children lack sufficient infection-fighting white cells, and identified the genetic cause of the syndrome: mutations in the gene Glucose-6-phosphatase, catalytic subunit 3 (G6PC3).

5 Jan 2009

A novel glioblastoma mouse model developed

Researchers at the Salk Institute for Biological Studies have developed a versatile mouse model of glioblastoma-the most common and deadly brain cancer in humans-that closely resembles the development and progression of human brain tumors that arise naturally.

5 Jan 2009

Why hip replacements fail

Each year thousands of patients undergo total hip replacement surgery in order to help alleviate pain associated with debilitating hip disease and other related hip problems.

5 Jan 2009

Peer discussion improves student performance with Clickers - simple audience response devices

Across the University of Colorado at Boulder campus students are sharing answers, checking their responses to questions against those of their neighbors and making adjustments to those answers in hopes of earning a better grade.

5 Jan 2009