New gene selection method

Jul 8 2004

Current microarray experiments allow the levels of activity of thousands of genes to be measured at once, providing a window into molecular events underlying health and disease.

The selection of genes having distinct levels of activity between conditions of interest (such as cancer and non-cancer) has therefore emerged as a key aim of data analysis. However, with typically many thousands of genes to choose from and at most a few dozen sets of measurements available, differential analyses of this kind are extremely challenging. Different statistical tests yield different results due to their underlying assumptions, but on real data it is usually impossible to tell which method is likely to be right.

Researchers at the University of Oxford have developed a new method that is able of provide a consistency measure for such tests. It is capable of assessing the effectiveness of each algorithm for particular data and it can be further utilised to learn how to produce an effective statistical method for testing the given data.

The new method has many distinct advantages and benefits in comparison with existing methods for screening. One of the main advantages is that it is able to assess statistical algorithms by selecting custom algorithms from data using a notion of consistency. The technique, which is extremely robust, helps to reduce the risk of choosing an inappropriate algorithm. This helps to minimise errors and therefore lead to significant potential reduction in the cost of producing data.

Although the most important application for this technique and the main reason that it was developed is that it can be used for highlighting genes responsible for disease, apart from other bioinformatic applications, the method is also suitable for use in identifying buying patterns from consumer records data and information retrieval from databases.

This work is patent application protected. Anybody interested in obtaining further information about this technology should contact Isis Innovation Ltd.

Isis Innovation Ltd is the technology transfer company for Oxford University. Isis was set up to help researchers within the University who wish to commercialise the results of their research. The services that Isis is able to provide for the academics includes; licensing intellectual property; facilitating the formation of new companies and providing help with the marketing of their consulting and services expertise.