Thymosin β4 exhibits potential as new therapeutic agent for liver failure due to chronic HBV infection

REGENERX BIOPHARMACEUTICALS, INC. (NYSE Amex:RGN) announced today that researchers have correlated Tβ4 levels with the clinical course of patients with hepatitis B virus-related liver failure. It was reported that serum thymosin β4 levels were significantly lower in patients with chronic hepatitis B infection and that the magnitude of the reduction of thymosin β4 was closely related to the severity of the hepatic injury and to patient death. Since patients with higher Tβ4 levels survived the disease, changes in Tβ4 values could reflect outcome in some liver failure patients.

“The study demonstrated that the thymosin β4 level was significantly lowered in liver failure patients, suggesting that thymosin β4 might become a new therapeutic agent for liver failure caused by chronic HBV infection”

Moreover, liver failure is a systemic inflammatory reaction, causing severe deterioration in liver function, according to the research team. Liver failure occurs when the extent of hepatocyte (liver cells) death exceeds the liver’s regenerating capacity and recent findings have shown that Tβ4 regulates certain molecules that play a role in preventing hepatic cell death and promoting hepatic regeneration. Liver regeneration is considered to be suppressed in liver failure. “The study demonstrated that the thymosin β4 level was significantly lowered in liver failure patients, suggesting that thymosin β4 might become a new therapeutic agent for liver failure caused by chronic HBV infection,” concluded the research team.

“This study is particularly important as it confirms and extends, in humans, data published (Annals. N.Y. Acad. Sci. 2007:1112:154-160) by Dr. Marcos Rojkind and his colleagues at The George Washington University Medical Center showing that Tβ4 up-regulates certain molecules known to play key roles in stimulating liver regeneration. It also strongly suggests that observing low levels of circulating Tβ4 in the blood may be a useful early warning signal to identify HBV patients, and perhaps patients with HCV infection, cirrhosis of the liver or other liver diseases, who are heading into liver failure,” stated Dr. Allan L. Goldstein, Professor of Biochemistry and Molecular Biology, The George Washington University School of Medicine, and chief scientific advisor to RegeneRx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
New MELD model improves liver transplant access for women