Experimental ‘golden’ potato could hold power to prevent disease in developing nations

An experimental "golden" potato could hold the power to prevent disease and death in developing countries where residents rely heavily upon the starchy food for sustenance, new research suggests.

A serving of the yellow-orange lab-engineered potato has the potential to provide as much as 42 percent of a child's recommended daily intake of vitamin A and 34 percent of a child's recommended intake of vitamin E, according to a recent study co-led by researchers at The Ohio State University.

Women of reproductive age could get 15 percent of their recommended vitamin A and 17 percent of recommended vitamin E from that same 5.3 ounce (150 gram) serving, the researchers concluded.

The study appears in the journal PLOS ONE.

Potato is the fourth most widely consumed plant food by humans after rice, wheat and corn, according to the U.S. Department of Agriculture. It is a staple food in some Asian, African and South American countries where there is a high incidence of vitamin A and vitamin E deficiencies.

"More than 800,000 people depend on the potato as their main source of energy and many of these individuals are not consuming adequate amounts of these vital nutrients," said study author Mark Failla, professor emeritus of human nutrition at Ohio State.

"These golden tubers have far more vitamin A and vitamin E than white potatoes, and that could make a significant difference in certain populations where deficiencies - and related diseases - are common," said Failla, a member of Ohio State's Foods for Health Discovery Theme.

Vitamin A is essential for vision, immunity, organ development, growth and reproductive health. And Vitamin A deficiency is the leading cause of preventable blindness in children. Vitamin E protects against oxidative stress and inflammation, conditions associated with damage to nerves, muscles, vision and the immune system.

In Failla's lab, researchers created a simulated digestive system including a virtual mouth, stomach and small intestine to determine how much provitamin A and vitamin E could potentially be absorbed by someone who eats a golden potato. Provitamin A carotenoids are converted by enzymes into vitamin A that the body can use. Carotenoids are fat-soluble pigments that provide yellow, red and orange colors to fruits and vegetables. They are essential nutrients for animals and humans.

"We ground up boiled golden potato and mimicked the conditions of these digestive organs to determine how much of these fat-soluble nutrients became biologically available," he said.

The main goal of the work was to examine provitamin A availability. The findings of the high content and availability of vitamin E in the golden potato were an unanticipated and pleasant surprise, Failla said.

The golden potato, which is not commercially available, was metabolically engineered in Italy by a team that collaborated with Failla on the study. The additional carotenoids in the tuber make it a more nutritionally dense food with the potential of improving the health of those who rely heavily upon potatoes for nourishment.

While plant scientists have had some success cross-breeding other plants for nutritional gain, the improved nutritional quality of the golden potato is only possible using metabolic engineering - the manipulation of plant genes in the lab, Failla said.

While some object to this kind of work, the research team stresses that this potato could eventually help prevent childhood blindness and illnesses and even death of infants, children and mothers in developing nations.

"We have to keep an open mind, remembering that nutritional requirements differ in different countries and that our final goal is to provide safe, nutritious food to 9 billion people worldwide," said study co-author Giovanni Giuliano of the Italian National Agency for New Technologies, Energy and Sustainable Development at the Casaccia Research Center in Rome.

Failla said "hidden hunger" - deficiencies in micronutrients - has been a problem for decades in many developing countries because staple food crops were bred for high yield and pest resistance rather than nutritional quality.

"This golden potato would be a way to provide a much more nutritious food that people are eating many times a week, or even several times a day," he said.