More than two-thirds of adults in the United States are overweight or obese. Eating foods containing high levels of fats and sugars -- the "Western diet" -- can lead to obesity and significantly reduce life expectancy.
Nicholas DiPatrizio, an assistant professor of biomedical sciences in the School of Medicine at the University of California, Riverside, has received a five-year grant of more than $1.7 million from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, or NIH, to identify novel gut-brain endocannabinoid signaling pathways that control feeding behavior and become impaired in obesity.
Our work, which will be done on a mouse model, will support the discovery and development of novel therapeutic strategies to safely treat obesity and related metabolic disorders. Currently, a critical barrier to effective treatment of obesity is a lack of reliable therapeutic options."
Nicholas DiPatrizio, assistant professor of biomedical sciences, UCR
Endocannabinoids are cannabis-like molecules made naturally by the body to regulate a wide variety of physiological processes. As with cannabis, endocannabinoids can enhance feeding behavior. The endocannabinoid system in mice is extremely similar to the one in humans.
Recent studies on mice from the DiPatrizio lab have shown that the endocannabinoid system in the gut plays a critical role in gut-brain signaling -- especially where feeling satiated is concerned. The system becomes impaired in diet-induced obesity, resulting in the mice steadily gaining weight and not feeling full even after consuming a large amount of food.
"We think the endocannabinoid system gets remodeled after exposure to high-energy nutrients and contributes to overeating in diet-induced obesity," DiPatrizio said. "Our preliminary results support this hypothesis."
DiPatrizio explained that food intake and energy balance are controlled by a dynamic interplay of gut-brain signaling pathways; the molecular underpinnings in these processes and their impairment in obesity, however, remain poorly understood.
"What are the specific components in the Western diet that at the molecular level impact gut-brain endocannabinoid system signaling and diet-induced obesity?" he said. "We will work to identify these components."
DiPatrizio, who recently received UCR's first cannabis grant, will be joined in the research by doctoral students and staff in his lab.
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