Witnessing sickness triggers anticipatory immune responses

Chapman UniversityNov 27 2023

It's well-known that when those around us get sick, there's a good chance we'll catch what they have, but new research reveals that simply observing a sick individual triggers a biological response.

Patricia Lopes, an assistant professor of biology at Chapman University, is studying how the body anticipates the possibility of infection just by witnessing someone else's symptoms. This phenomenon raises questions about the interconnectedness of individuals within a social group and how the perception of sickness can influence the health and behavior of others.

Her recent work showed that when healthy animals interacted with animals showing disease symptoms, they activated molecular pathways related to immune responses and changed their egg composition. These types of responses are also found in humans, as summarized in Lopes's publication in Functional Ecology.

This research has helped unveil another level of the hidden ripple effects of infections, showing that when one individual falls ill, it's not just their problem – it's a complex story that can impact the health and behavior of many others."

Dr. Patricia Lopes, assistant professor of biology, Chapman University

Researchers don't yet understand how long these anticipatory responses last but note that they shouldn't replace preventative measures like vaccines. Lopes is currently funded by a National Science Foundation grant to study how these anticipatory responses come about and whether they have any protective effect for the organisms experiencing them.

Lopes highlights the importance of studying how sick individuals affect those around them in her most recent publication in the September issue of Trends in Ecology & Evolution.