In individuals who have undergone knee or hip replacement surgery, clinicians are noticing increasing numbers of chronic bone infections linked to a bacterial strain commonly found on the skin. A new study published in the Journal of Orthopaedic Research provides insights into the mechanisms involved.
Utilizing mouse models of bone infection and systematic electron microscopy studies, scientists found that the common skin bacteria Cutibacterium acnes can persist as layers of biofilms for weeks on contaminated titanium or stainless-steel implants. It can also invade deep pockets of the bone called canalicular networks and be present within the bone for long periods of time.
Our study highlights that osteocyte lacuno-canalicular networks can be a major reservoir for this bacterium and potentially provides a novel mechanism of why Cutibacterium acnes chronic bone infections are difficult to treat in the clinic."
Gowrishankar Muthukrishnan, PhD, corresponding author of the University of Rochester Medical Center
Source:
Journal reference:
Botros, M., et al. (2024) Cutibacterium acnes invades submicron osteocyte lacuno-canalicular networks following implant-associated osteomyelitis. Journal of Orthopaedic Research. doi.org/10.1002/jor.25929.
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