Thank you Dr Maho, your explanation is one of the best I have seen, very easy to understand.
Would you please explain a little further, as I have some confusion in regard to Citrulline supplementation helping eliminate ammonia by it's support of the Urea cycle.

You said:
Carbamoyl phosphate is formed from ammonia and bicarbonate, by carbamoyl phosphate synthetase (CPS).
Ornithine transcarbamoylase (OTC) condenses carbamoyl phosphate and ornithine to form citrulline.

This suggests to me that citrulline is a product formed from ammonia, therefore how does supplemental citrulline which must also be a product of ammonia reduce the body burden of ammonia? (I am asking this because I have read in numerous articles that supplemental citrulline will assist in eliminating ammonia. But they didn't explain how it is possible.)

Thank you
Greg