Metformin and glimepiride together worked well for me until they lost their efficacy, as diabetes drugs eventually do in most cases. Once you realize that maximum doses of any drugs don't work any more (after a couple of months), don't go to your family doctor. Instead, go to see an endocrinologist and start taking insulin. Family physicians are notoriously cautious in suggesting this at the expense of their patients' health.
Unless your insurance pays for all of your insulin (and very few do), ask your endocrinologist to put you on the least expensive kind - Novo Nordisk's Relion N, which can be had at Wal Mart for 25 bucks a vial and for even less thru insurance. Endocrinologists like to start you on expensive pen-type injectors, and I suspect there are sweet deals with drug companies involved. I used Lantus Solo Star pen for a year, and it cost me about a $1,000.00 - with insurance! I then asked to be switched to Relion, which I find to be just as good (unlike Eli Lilly's Humulin N) at about the fifth of the Lantus cost.