Posted in | Preclinical Imaging

A Universal MicroCT Analysis Pipeline for Bone Preclinical Disease Models

From Feb 1 2018

Getting a good microCT image of your animal’s bone, in vivo or ex vivo, is just the start. To realize the goals of your preclinical study, quantitative outcomes are needed. From two decades of experience, Bruker microCT brings a universal microCT analysis pipeline – a transparent flexible system and workflow that can deliver your needed quantitative outcomes, for every disease model.

With some systems on the market, each individual disease model and analysis requires a new software module or attachment and big new software bill! Not so with Bruker CT-Analyzer and CT-Voxel. This powerful yet intuitive system builds on a simple pipeline to deliver results for any bone analysis scenario.

Presenters

Phil Salmon, PhD

Phil Salmon, PhD - Application Scientist, Bruker microCT
 

What is this pipeline?

  • Think about what you want to find out. Plan the in-vivo study and imaging method accordingly. Run a pilot study first if necessary. Does the method resolve what you need to see?
  • Scan bone sites in-vivo or ex-vivo by microCT for 3D morphometry and/or densitometry
  • Align the 3D image for consistent and optimal selection of a region of interest for analysis
  • Region of interest: setting this is the key to equivalence between animals and power and accuracy in the resulting data
  • Segmentation: apply an suitable binary threshold for bone or other tissues or biomaterials to be analyzed
  • 3D analysis and interpretation of the morphometric and/or densitometric data.

This pipeline is easy to learn and can be applied to models of osteoporosis, arthritis, bone tumor and metastasis, fracture callus, defect healing with biomaterials, articular cartilage deficit, genetic phenotypes and even others yet to be developed (or to be developed by you).

Who should attend

  • Researchers in bone biology and orthopedics, including osteoporosis, arthritis, bone tumor, biomaterials, fracture healing and any other bone related discipline.
  • Research technicians involved in imaging and image analysis.
  • Pharmaceutical decision makers involved in planning discovery and screening programs related to bone health.
  • Scientists involved in microCT imaging and quantitative image analysis.

Other Webinars from Bruker BioSpin - NMR, EPR and Imaging

Dynamic Nuclear Polarization in the study of pharmaceuticals

Dynamic Nuclear Polarization in the study of pharmaceuticals
Potency Determination by qNMR

Potency Determination by qNMR
High speed spectroscopy – New AVANCE NEO

High speed spectroscopy – New AVANCE NEO
Is it really pure honey? Detecting adulterations, frauds and quality issues by NMR-based Honey-Profiling

Is it really pure honey? Detecting adulterations, frauds and quality issues by NMR-based Honey-Profiling
Solid State NMR Made Easy

Solid State NMR Made Easy
In Vivo Tumor Progression Studies: The Relative Strengths of Available Imaging Modalities and Reporter Constructs

In Vivo Tumor Progression Studies: The Relative Strengths of Available Imaging Modalities and Reporter Constructs
Studying Cancer biology and Therapeutic Targets Using PET Technology: Opening an Extraordinary Option

Studying Cancer biology and Therapeutic Targets Using PET Technology: Opening an Extraordinary Option
Automatizing the qualitative and quantitative analysis of complex drugs using NMR

Automatizing the qualitative and quantitative analysis of complex drugs using NMR
Imaging of Infection and Tumors using labelled Siderophores

Imaging of Infection and Tumors using labelled Siderophores
Metabolic Imaging in Neurodegenerative Disease using CEST MRI

Metabolic Imaging in Neurodegenerative Disease using CEST MRI
In vivo Magnetic Resonance Imaging

In vivo Magnetic Resonance Imaging
NMR-based fragment screening for drug discovery

NMR-based fragment screening for drug discovery
Pharmaceutical Applications of Electron Paramagnetic Resonance (EPR) Spectroscopy

Pharmaceutical Applications of Electron Paramagnetic Resonance (EPR) Spectroscopy
Improving Mechanistic Understanding of Fast Reactions Using Rapid, Reproducible In Situ Analysis by Stop-Flow NMR and IR

Improving Mechanistic Understanding of Fast Reactions Using Rapid, Reproducible In Situ Analysis by Stop-Flow NMR and IR
EPR as a Teaching Tool in the Laboratory

EPR as a Teaching Tool in the Laboratory
How microCT Can Provide Insight into Dynamic Disease Processes

How microCT Can Provide Insight into Dynamic Disease Processes
Solid Form Quantification – A New Benchtop Solution

Solid Form Quantification – A New Benchtop Solution
Webinar Overview: EPR as a Teaching Tool in the Laboratory

Webinar Overview: EPR as a Teaching Tool in the Laboratory
Intelligent Use of NMR for Synthetic Organic Chemistry

Intelligent Use of NMR for Synthetic Organic Chemistry
Early Disease Detection Performing NMR

Early Disease Detection Performing NMR
Using Micro-CT Imaging for the Phenotyping and Analysis of Bone Architecture

Using Micro-CT Imaging for the Phenotyping and Analysis of Bone Architecture
Using High Fields to Combat Ischemic Stroke with Cell Therapy

Using High Fields to Combat Ischemic Stroke with Cell Therapy
Endodontic Applications of Microcomputed Tomography for Studying Root Canals

Endodontic Applications of Microcomputed Tomography for Studying Root Canals
Studying Cardiovascular Pathology with MRI

Studying Cardiovascular Pathology with MRI
Improved Open-Access NMR for the Synthetic and Analytical Chemistry Laboratories

Improved Open-Access NMR for the Synthetic and Analytical Chemistry Laboratories
DTI Connectomics in Mouse Models of Neurological Disorders

DTI Connectomics in Mouse Models of Neurological Disorders
Monitoring Cancer Treatments with Immuno-PET

Monitoring Cancer Treatments with Immuno-PET
Early Detection of Metabolic Remodeling in Pressure Overload Left Ventricle Hypertrophy Using Dynamic PET Imaging

Early Detection of Metabolic Remodeling in Pressure Overload Left Ventricle Hypertrophy Using Dynamic PET Imaging
Introducing the Next Revolution in EPR, the Rapid Scan Accessory

Introducing the Next Revolution in EPR, the Rapid Scan Accessory
MicroCT Applications in Lung Research and Immunology

MicroCT Applications in Lung Research and Immunology
Micro-CT in 3D Data Integration and (Clinical) Workflows for Digital Orthodontics

Micro-CT in 3D Data Integration and (Clinical) Workflows for Digital Orthodontics
Ex Vivo MicroangioCT: Advances in Microvascular Imaging

Ex Vivo MicroangioCT: Advances in Microvascular Imaging
Treatments of COVID-19: Old Drugs, New Tricks

Treatments of COVID-19: Old Drugs, New Tricks
NMR Characterization of Polysaccharide-Based Vaccines

NMR Characterization of Polysaccharide-Based Vaccines
Hyperpolarized Xe MRI of Pulmonary Gas-Exchange in Rodents

Hyperpolarized Xe MRI of Pulmonary Gas-Exchange in Rodents
PET Image Reconstruction Overview - Current and Future Trends

PET Image Reconstruction Overview - Current and Future Trends
Unlocking your clinical understanding of Post-Acute COVID Syndrome (PACS), patient recover, and risk of subsequent disease

Unlocking your clinical understanding of Post-Acute COVID Syndrome (PACS), patient recover, and risk of subsequent disease
New Psychoactive Substances (NPS): automated identification and quantification

New Psychoactive Substances (NPS): automated identification and quantification
Present and future of human metabolomics (for research use only)

Present and future of human metabolomics (for research use only)
NMR based lipoprotein phenotyping can reveal recovery subgroups in SARS-CoV 2 infected patients

NMR based lipoprotein phenotyping can reveal recovery subgroups in SARS-CoV 2 infected patients
How to easily automate chemical mixture analysis

How to easily automate chemical mixture analysis
Evolving your biobank business model

Evolving your biobank business model
Improving rapid narcotics analysis in the detection of illegal drugs

Improving rapid narcotics analysis in the detection of illegal drugs
PET/MR imaging to study liver diseases

PET/MR imaging to study liver diseases
How to Validate and Implement qNMR as a Platform Method for Oligonucleotides

How to Validate and Implement qNMR as a Platform Method for Oligonucleotides
Advanced PET/MRI Techniques for Characterizing Hypoxic Breast Cancer Tumors

Advanced PET/MRI Techniques for Characterizing Hypoxic Breast Cancer Tumors
The role of lipoproteins in inflammatory response

The role of lipoproteins in inflammatory response

Life Science Webinars by Subject Matter

Watch the
Webinar

More Articles from
Bruker BioSpin - NMR, EPR and Imaging

More Products from
Bruker BioSpin - NMR, EPR and Imaging

See all content from Bruker BioSpin - NMR, EPR and Imaging
Watch the
Webinar

Terms

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

Provide Feedback