Immunosuppression News and Research

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Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

Fourth dose of COVID-19 vaccine reduced death among hospitalized patients during Omicron wave in Israel

Researchers investigated the effect of a fourth dose of the coronavirus disease 2019 (COVID-19) vaccine in patients with severe disease symptoms.

2 May 2022

The impact of leronlimab on CCR5 surface cell levels during long COVID

The researchers assessed the impact of long COVID-19 on C-C chemokine receptor-5 (CCR5) and immunosuppression.

26 Apr 2022

Anti-SARS-CoV-2 spike antibody levels following COVID-19 BNT162b2 vaccination

Researchers assessed factors influencing the anti-severe acute respiratory syndrome coronavirus 2 spike antibodies after SARS-CoV-2 BNT162b2 vaccination.

25 Apr 2022

An abnormally suppressed immune system may be to blame in some cases of long COVID-19

A UCLA-led team of researchers studying the effect of the monoclonal antibody Leronlimab on long COVID-19 may have found a surprising clue to the baffling syndrome, one that contradicts their initial hypothesis.

22 Apr 2022

Additional booster doses of COVID-19 vaccine help protect solid organ transplant recipients

Additional booster doses of vaccine against COVID-19 are particularly important for those who are immunosuppressed, namely those who have had solid organ transplants, a new study shows.

13 Apr 2022

Pod-based e-cigarette use alters the inflammatory state across multiple organ systems

Researchers at University of California San Diego School of Medicine report that daily use of pod-based e-cigarettes alters the inflammatory state across multiple organ systems including the brain, heart, lungs and colon. Effects also vary depending on the e-cigarette flavor, and can influence how organs respond to infections, such as SARS-CoV-2.

13 Apr 2022

Severe COVID-19 extremely rare among children

A new Journal of Infection study describes the findings in children who contracted SARS-CoV-2 infection in England.

12 Apr 2022

Study identifies risk factors for severe COVID-19 in hospitalized children in Canada

Researchers evaluated the risk factors for severe COVID-19 among hospitalized children in Canada.

12 Apr 2022

Researchers design RNA molecules for delivering therapies directly to beta cells

Investigators at the University of Miami Miller School of Medicine have designed RNA molecules that home to human pancreatic beta cells, the cells that produce insulin and are destroyed in patients with type 1 and type 2 diabetes.

7 Apr 2022

Patient outcomes after influenza, RSV, or SARS-CoV-2 hospitalization

A recent study posted to the medRxiv* preprint server investigated the elements that predicted all-cause mortality among individuals hospitalized due to influenza, respiratory syncytial virus (RSV), or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

7 Apr 2022

Evaluating serological responses to repeated COVID-19 vaccination in kidney transplant recipients

Researchers analyzed whether repeated vaccinations against COVID-19 increase serological response in non-responding kidney transplant recipients.

29 Mar 2022

New pancreatic islet cryopreservation protocol could pave the way for diabetes cure

Engineering and medical researchers at the University of Minnesota Twin Cities and Mayo Clinic have developed a new process for successfully storing specialized pancreatic islet cells at very low temperatures and rewarming them, enabling the potential for on-demand islet transplantation.

24 Mar 2022

SARS-CoV-2 mRNA vaccines may prevent COVID-19-associated mechanical ventilation and death

Researchers performed a case-control study to evaluate the effectiveness of SARS-CoV-2 messenger ribonucleic acid vaccines.

23 Mar 2022

Frail and older males more vulnerable to COVID-19 than females

Researchers evaluated the association of biological sex, frailty, and age with the vaccine-elicited immunity against SARS-CoV-2.

17 Mar 2022

Viral load reduction effectiveness of SARS-CoV-2 BNT162b2 mRNA booster vaccine wanes with time

In a new study, researchers conducted a retrospective analysis of the SAR-CoV-2 reverse transcriptase - quantitative polymerase chain reaction test measurements.

9 Mar 2022

Relationship between immunological responses in the acute phase of SARS-CoV-2 infection and long-term cognitive deficits

A recent study reported that monocytosis during the acute phase of coronavirus disease 2019 could forecast anosognosia in long COVID.

8 Mar 2022

Researchers develop scoring tools to determine hospitalization and mortality risk in COVID-19 patients

Researchers conducted a large retrospective study on a cohort of severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 patients, developing and validating a simple and precise scoring tool to risk stratify COVID-19 ambulatory and emergency department patients for subsequent hospitalizations and mortalities.