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New atomic-level model helps explain how SARS-CoV-2 causes extensive lung damage

Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have published the first detailed atomic-level model of the SARS-CoV-2 "envelope" protein bound to a human protein essential for maintaining the lining of the lungs.

8 Jun 2021

Testing placental hormone levels can help identify candidates for pregnancy complications

Women who will develop potentially life-threatening disorders during pregnancy can be identified early when hormone levels in the placenta are tested, a new study has shown.

8 Jun 2021

Researchers identify a novel host-directed therapeutic approach to COVID-19

Researchers in the UK have demonstrated the potential of modulating the expression of angiotensin-converting enzyme 2 (ACE2) as a novel host-directed therapeutic approach to protecting against coronavirus disease 2019 (COVID-19).

8 Jun 2021

New measure of heart function could improve survival for people with heart failure

A new physiological measurement of heart function developed at UVA Health could improve survival for people with heart failure by identifying high-risk patients who require tailored treatments, a new study suggests.

8 Jun 2021

Kidney experts say it’s time to remove race from medical algorithms. Doing so is complicated.

Alphonso Harried recently came across a newspaper clipping about his grandfather receiving his 1,000th dialysis treatment. His grandfather later died — at a dialysis center — as did his uncle, both from kidney disease.

8 Jun 2021

Immunomodulatory therapies for nephrological autoimmune diseases may help treat severe COVID-19

Various viruses and bacteria have long been known to cause autoimmune diseases where there is such a predisposition. This phenomenon also seems to play a major role in SARS-CoV-2, especially in severe courses.

8 Jun 2021

ACE2 functions as a gateway for COVID-19 virus

Normally, the ACE2 enzyme helps regulate our blood pressure. The enzyme sits on the surface of cells, including cells in the lungs, but in connection with COVID-19 it has been found that ACE2 also functions as a gateway for the virus.

8 Jun 2021

Study examines how SARS CoV-2 aerosols travel through the lower lungs

When we inhale isolated coronavirus particles, more than 65% reach the deepest region of our lungs where damage to cells can lead to low blood oxygen levels, new research has discovered, and more of these aerosols reach the right lung than the left.

8 Jun 2021

New research identifies protein as therapeutic anti-viral target for COVID-19

New research identified a novel interaction between the SARS-CoV-2 spike protein and the galectin-3-binding protein (LGALS3BP) which could be a new therapeutic anti-viral target.

7 Jun 2021

Ultrasound examinations can be deployed to detect and treat lung congestion in hemodialysis patients

Accumulation of water in the lungs (lungcongestion) is a common condition in hemodialysis patients, particularly in those at high cardiovascular risk, like those presenting coronary artery disease and/or heart failure.

7 Jun 2021

COVID-19 can cause long-term consequences for the kidneys

The kidneys are a target organ of COVID-19 and are affected very early in the course. However, this is precisely where there is strong prognostic potential: As early as last spring, COVID-19-associated nephritis was identified as an early warning signal for severe courses of the infectious disease and studies to that effect were published.

7 Jun 2021

Repeated low-dose dose exposure to SARS-CoV-2 may protect against severe COVID-19

The Italian authors of this paper, published in the journal Viruses, have taken this hypothesis and expanded it to include viral particles suspended in the air or on inanimate objects as a possible source of T cell immunity due to the repeated low-dose exposure, potentially explaining virus immunity found in non-infected individuals.

7 Jun 2021

Researchers uncover molecular mechanism linking Parkinson’s disease with COVID-19

The study findings reveal that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in abnormal modification of some lung proteins, which are subsequently transported to the brain via exosomes. In the brain, these modified lung proteins disrupt the normal functioning of proteins that are related to Parkinson’s disease.

7 Jun 2021

Shorter treatment regimen found to be effective for treating TB

Tuberculosis (TB) is a deadly infection that occurs in every part of the world. The standard treatment for TB, a six-month multidrug regimen, has not changed in more than 40 years. Patients can find it difficult to complete the lengthy regimen, making it more likely that treatment resistance will develop.

5 Jun 2021

SARS-CoV-2 evades neutralizing antibodies and rapidly spreads by cell fusion, finds study

In a new study by researchers in the UK, Germany and South Africa, this process is visualized using time-lapse microscopy of a human cell lung line, demonstrating that SARS-CoV-2 can induce cell-to-cell fusion within 6 hours post-infection. Further, the application of neutralizing monoclonal antibodies or convalescent plasma was unable to prevent the spread of the virus by this mechanism, suggesting that removing SARS-CoV-2 from cells permissive of cell membrane fusion could be more difficult than other types of cell.

4 Jun 2021

Three cases of stroke reported in young adults following covid-19 vaccination

Clots in the arteries (arterial thrombosis) are the most common cause of stroke (ischemic stroke) and have been reported in detail for the first time in young adults who received the Oxford–AstraZeneca covid-19 vaccine in a letter from UK stroke specialists published online in Journal of Neurology Neurosurgery & Psychiatry.

4 Jun 2021

Mast cell activation may underlie inflammation in severe COVID-19

A new preprint research paper posted to the medRxiv* server points to mast cells as major culprits in the etiology of severe and critical COVID-19. This could suggest suitable therapeutic and preventive interventions to reduce the morbidity and mortality of this viral illness.

3 Jun 2021

NIH study identifies promising oral antiviral treatment for COVID-19

The experimental drug TEMPOL may be a promising oral antiviral treatment for COVID-19, suggests a study of cell cultures by researchers at the National Institutes of Health.

3 Jun 2021

Lung protein hyperconcentration may be a key factor in predicting COPD risks

Airway mucus consists of various proteins such as long mucins MUC5AC and MUC5B, both of which contribute greatly to the proper gel-like consistency of this most essential bodily fluid.

3 Jun 2021

Study reveals prevalence of multimorbidity among people using methamphetamine

People who use methamphetamine are more likely to have health conditions, mental illness, and substance use disorders than people who do not use the drug, according to a new study by researchers at the Center for Drug Use and HIV/HCV Research (CDUHR) at NYU School of Global Public Health.

3 Jun 2021

Lungs News and Research

New atomic-level model helps explain how SARS-CoV-2 causes extensive lung damage

Testing placental hormone levels can help identify candidates for pregnancy complications

Researchers identify a novel host-directed therapeutic approach to COVID-19

New measure of heart function could improve survival for people with heart failure

Kidney experts say it’s time to remove race from medical algorithms. Doing so is complicated.

Immunomodulatory therapies for nephrological autoimmune diseases may help treat severe COVID-19

ACE2 functions as a gateway for COVID-19 virus

Study examines how SARS CoV-2 aerosols travel through the lower lungs

New research identifies protein as therapeutic anti-viral target for COVID-19

Ultrasound examinations can be deployed to detect and treat lung congestion in hemodialysis patients

COVID-19 can cause long-term consequences for the kidneys

Repeated low-dose dose exposure to SARS-CoV-2 may protect against severe COVID-19

Researchers uncover molecular mechanism linking Parkinson’s disease with COVID-19

Shorter treatment regimen found to be effective for treating TB

SARS-CoV-2 evades neutralizing antibodies and rapidly spreads by cell fusion, finds study

Three cases of stroke reported in young adults following covid-19 vaccination

Mast cell activation may underlie inflammation in severe COVID-19

NIH study identifies promising oral antiviral treatment for COVID-19

Lung protein hyperconcentration may be a key factor in predicting COPD risks

Study reveals prevalence of multimorbidity among people using methamphetamine

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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