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Nanobodies from llamas could be used to deliver targeted medicines to human muscle cells

In "proof of concept" experiments with mouse and human cells and tissues, Johns Hopkins Medicine researchers say they have designed tiny proteins, called nanobodies, derived from llama antibodies, that could potentially be used to deliver targeted medicines to human muscle cells.

12 May 2022

Clonality and magnitude of SARS-CoV-2-reactive CD4+ T cells in COVID-19 convalescent patients after vaccination

A new study has focussed on determining the clonality and levels of SARS-CoV-2-reactive CD4+ T cells in CCPs post-vaccination.

12 May 2022

Delta- and Omicron BA.1-variant specificity of B cell repertoires established by an initial Wuhan strain infection

Researchers performed an unbiased evaluation of the early memory B cell repertoire specific for the Omicron and Delta variants of SARS-CoV-2.

12 May 2022

Imprinted antibody responses towards SARS-CoV-2 Omicron subvariants

A new study analyzed the imprinted antibody responses towards the SARS-CoV-2 Omicron subvariants.

12 May 2022

Study shows reduced respiratory syncytial virus antibody levels in women of childbearing age and infants during the COVID-19 pandemic

A study demonstrated that the humoral immunity against the respiratory syncytial virus (RSV) has significantly reduced.

12 May 2022

Messenger RNA COVID-19 vaccines induce high levels of short-lived antibodies compared to natural infection

Researchers extensively investigated the dynamics of antibodies induced by natural SARS-CoV-2 infection and vaccination in Qatar's diverse population

12 May 2022

SARS-CoV-2 Omicron escapes immune response due to high ACE2 affinity and low antibody specificity

In a recent study published in the journal Vaccines, researchers revealed how severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron evades neutralizing antibodies (nAbs).

12 May 2022

Antifungal agent Bifonazole as an antiviral against SARS-CoV-2

In a recent study published in the journal Molecular Therapy, researchers identified Bifonazole, an imidazole-based antifungal agent, to have potent activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using high-throughput screening of small molecules.

12 May 2022

Research describes how DNA damage can affect neural health and function

A new research paper in the journal EMBO Reports describes how DNA damage can affect neural health and function.

12 May 2022

Study shows efficacy of COVID-19 vaccine in people receiving cancer treatment

People undergoing active cancer treatment, including stem cell transplant, should receive the COVID-19 vaccine, according to a study published in JAMA Oncology.

11 May 2022

Review portrays clinical journey of messenger RNA vaccines and mRNA-based therapies

Researchers reviewed messenger ribonucleic acid (mRNA) technology and highlighted its clinical applications.

11 May 2022

Effectiveness of COVID-19 monoclonal antibodies against SARS-CoV-2 Omicron variant

Researchers depicted the efficacy of the SARS-CoV-2 monoclonal antibodies (mAbs) against the SARS-CoV-2 Omicron variant.

11 May 2022

Vaccine features that could induce durable humoral immune responses against SARS-CoV-2

A new study explored key vaccine features which could help induce and preserve humoral immunity against SARS-CoV-2 infection.

11 May 2022

Susceptibility of four SARS-CoV-2 Omicron sub-lineages to vaccines and monoclonal antibodies

Researchers demonstrated that four SARS-CoV-2 Omicron sub-lineages, BA.1, BA.1.1, BA.2, and BA.3, are resistant to current COVID-19 vaccines and antibody therapeutics to varying extents.

11 May 2022

Study investigates antibody-mediated response against different SARS-CoV-2 variants

In a recent study posted to the bioRxiv* preprint server, researchers assessed the impact of coronavirus disease 2019 (COVID-19) on antibody-mediated immunity.

10 May 2022

Decoy ACE2 nanoparticles block the entry of SARS-CoV-2 into cells

In a recent study posted to the bioRxiv* preprint server, researchers reported that nanoparticles could prevent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) cell entry.

10 May 2022

Evasion of COVID-19 vaccine-medicated mucosal immunity by SARS-CoV-2 Omicron

Researchers depicted the evasion of the SARS-CoV-2 Omicron variant to mucosal immunity in SARS-CoV-2 vaccine recipients.

10 May 2022

Simulating molecular dynamics of SARS-CoV-2 spike variants in the locked conformation

Researchers retrieved the first-ever sequenced spike (S) protein structures of the original Wuhan-Hu 1 SARS-CoV-2 strain, the Alpha, Delta, Delta-plus variants, and Omicron sub-variants BA.1 and BA.2 and compared their structural and molecular level variations.

10 May 2022

Heightened antibody responses in COVID-19 booster vaccinated individuals following SARS-CoV-2 Omicron

Investigators illustrated that a SARS-CoV-2 Omicron infection post-booster vaccination imparts robust, long-lasting immunity against future re-infections.

10 May 2022

mRNA boosters enhance neutralization of SARS-CoV-2 BA.1, BA.2 and BA.3

A study recently published in the journal Cell Host & Microbe has described that all three sublineages of the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibit similar host cell entry efficiency and are neutralized equally by antibodies generated in response to coronavirus disease 2019 (COVID-19) booster vaccination

10 May 2022

Antibodies News and Research

Nanobodies from llamas could be used to deliver targeted medicines to human muscle cells

Clonality and magnitude of SARS-CoV-2-reactive CD4+ T cells in COVID-19 convalescent patients after vaccination

Delta- and Omicron BA.1-variant specificity of B cell repertoires established by an initial Wuhan strain infection

Imprinted antibody responses towards SARS-CoV-2 Omicron subvariants

Study shows reduced respiratory syncytial virus antibody levels in women of childbearing age and infants during the COVID-19 pandemic

Messenger RNA COVID-19 vaccines induce high levels of short-lived antibodies compared to natural infection

SARS-CoV-2 Omicron escapes immune response due to high ACE2 affinity and low antibody specificity

Antifungal agent Bifonazole as an antiviral against SARS-CoV-2

Research describes how DNA damage can affect neural health and function

Study shows efficacy of COVID-19 vaccine in people receiving cancer treatment

Review portrays clinical journey of messenger RNA vaccines and mRNA-based therapies

Effectiveness of COVID-19 monoclonal antibodies against SARS-CoV-2 Omicron variant

Vaccine features that could induce durable humoral immune responses against SARS-CoV-2

Susceptibility of four SARS-CoV-2 Omicron sub-lineages to vaccines and monoclonal antibodies

Study investigates antibody-mediated response against different SARS-CoV-2 variants

Decoy ACE2 nanoparticles block the entry of SARS-CoV-2 into cells

Evasion of COVID-19 vaccine-medicated mucosal immunity by SARS-CoV-2 Omicron

Simulating molecular dynamics of SARS-CoV-2 spike variants in the locked conformation

Heightened antibody responses in COVID-19 booster vaccinated individuals following SARS-CoV-2 Omicron

mRNA boosters enhance neutralization of SARS-CoV-2 BA.1, BA.2 and BA.3

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