Small Molecules News and Research

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Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Researchers demonstrate enhanced loss-of-function editing of CRISPR/Cas9 in human cells.

14 Mar 2022

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Researchers screened 5,000 Food and Drug Association-approved drugs to identify repurposed drugs targeting SARS-CoV-2 spike protein cleavage at both S1/S2 boundary and S2’.

11 Mar 2022

Study shows SARS-CoV-2 infection induces global alterations of the host endomembrane system

Researchers observed that Golgi fragmentation induced by SARS-CoV-2 facilitates viral trafficking.

11 Mar 2022

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Researchers led by Christopher Garcia of the Ludwig Center at Stanford University have solved the long-sought structure of a large signaling protein involved in responses to infection, inflammation, the generation of immune cells and when dysregulated by mutation-; the emergence of blood cancers known as myeloproliferative neoplasms.

11 Mar 2022

A new view of SARS-CoV-2 genome structure

Researchers performed DMS mutational profiling with sequencing and DREEM clustering to determine the SARS-CoV-2 RNA secondary structure.

8 Mar 2022

Scientists predict structure of SARS-CoV-2 frameshifting pseudoknot

Researchers recently unveiled the structure of programmed -1 ribosomal frameshifting pseudoknot of SARS-CoV-2.

8 Mar 2022

Identification of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding

Researchers discovered compounds able to inhibit SARS-CoV-2 macrodomain 1 and adenosine diphosphate-ribose binding via high throughput screening.

7 Mar 2022

Integrity Bio and LakePharma Become Curia

Companies Unite Under One Brand to Provide Seamless, Comprehensive Biologics Discovery, Development and Manufacturing Solutions

From Curia Global, Inc. 15 Feb 2022

Researchers reveal new therapeutic way to block oncogenic RAS mutants

As a 10-year journey comes to fruition, MUSC Hollings Cancer Center researcher John O'Bryan, Ph.D., and colleagues have demonstrated a new therapeutic way to block a protein that is frequently mutated in cancers.

9 Feb 2022

UCLA researchers develop a smartwatch that assesses cortisol levels found in sweat

The human body responds to stress, from the everyday to the extreme, by producing a hormone called cortisol.

9 Feb 2022

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

The Damon Runyon Cancer Research Foundation has announced its newest cohort of Damon Runyon Fellows, 13 outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

29 Jan 2022

SARS-CoV-2 virus co-opts intrinsic cellular machinery to suppress interferon production

In a recent study posted to the bioRxiv* preprint server, researchers evaluated the mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated inflammatory marker interferon (IFN) repression in hosts.

25 Jan 2022

Link established between gut microbiota and chronic inflammatory diseases

An international research team has established a link between gut microbiota and chronic inflammatory diseases such as arthritis.

25 Jan 2022

New COVID-19 vaccine promises vaccine equity because it has no patents

Corbevax, a new vaccine against COVID-19, may have better success as a candidate for vaccine equity because it carries no patents, relies on long-established recombinant technology for manufacture and has the support of the US and Indian governments, its makers and health experts say.

21 Jan 2022

Small Molecules News and Research

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Study shows SARS-CoV-2 infection induces global alterations of the host endomembrane system

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

A new view of SARS-CoV-2 genome structure

Scientists predict structure of SARS-CoV-2 frameshifting pseudoknot

Identification of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding

Integrity Bio and LakePharma Become Curia

Researchers reveal new therapeutic way to block oncogenic RAS mutants

UCLA researchers develop a smartwatch that assesses cortisol levels found in sweat

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

SARS-CoV-2 virus co-opts intrinsic cellular machinery to suppress interferon production

Link established between gut microbiota and chronic inflammatory diseases

New COVID-19 vaccine promises vaccine equity because it has no patents

Exploring biological characteristics of SARS-CoV-2-induced myocardial damage

Study finds SARS-CoV-2 infection caused significant changes in the levels of stress associated small RNAs

AI-driven solution predicts RNA and DNA binding sites to accelerate rational drug discovery

NYBC discovers novel small-molecule pancoronavirus fusion inhibitors

From laboratory to clinic - Nanotechnology-enabled mRNA COVID-19 vaccines

Small molecule identified as a SARS-CoV-2 inhibitor

Shaping the Future of Neuroscience: A Conversation with Atlas Antibodies on the MolBoolean™ and the Impact of SfN 2024

How the Arts Reshape Brain Function: Susan Magsamen on the Future of Neuroaesthetics

Inside the Alzheimer's Association: Dr. Heather Snyder on Driving Research and Collaboration

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