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Comprehensive tumor profiling reveals why osteosarcoma does not respond to immunotherapy

Comprehensive profiling of tumor samples taken from patients with osteosarcoma shows that multiple factors contribute to the traditionally poor responses observed from treatment with immune checkpoint inhibitors, according to new research from The University of Texas MD Anderson Cancer Center.

22 Feb 2020

Isolating Single T-cells of Interest using an Optofluidic Platform

Researchers are in desperate need of single-cell analysis techniques and those that allow the isolation of high-value T-cells for research and development.

From Bruker Cellular Analysis 21 Feb 2020

Bioengineers create light-controllable CAR T cells for cancer immunotherapy

Bioengineers at the University of California San Diego have developed a control system that could make CAR T-cell therapy safer and more powerful when treating cancer.

19 Feb 2020

Lengthening prostate cancer screening intervals for men could improve outcomes

A new study in JNCI: Journal of the National Cancer Institute, published by Oxford University Press, finds significant benefits to lengthening the amount of time between prostate cancer screenings for men.

18 Feb 2020

Scientists use toxin from rattlesnake venom for chronic pain

Rattlesnake (Crotalus adamanteus) is the largest venomous snake in North America, reaching 8 feet and weighing up to 10 pounds. In the past, medical experts believe that the toxin in rattlesnake venom, crotoxin, is a promising compound for the treatment of chronic pain.

18 Feb 2020

UCLA researcher designs ways for immune cells to 'outsmart' solid tumors

Yvonne Chen engineers immune cells to target their most evasive enemy: cancer. New cancer immunotherapies generate immune cells that are effective killers of blood cancers, but they have a hard time with solid tumors.

16 Feb 2020

Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain

Crotoxin, extracted from the venom of the South American rattlesnake Crotalus durissus terrificus, has been studied for almost a century for its analgesic, anti-inflammatory and antitumor activities and as an even more powerful muscle paralyzer than botulinum toxin.

16 Feb 2020

Scientists create world’s first model of pituitary disease using human iPS cells

Researchers at Kobe University's Graduate School of Medicine have developed the world's first congenital pituitary hypoplasia model using patient-derived iPS cells.

14 Feb 2020

Study provides a detailed molecular snapshot of endometrial cancer

A study published Feb. 13 in Cell provides an unprecedented look at the dozens of molecular steps that occur to bring about endometrial cancer, commonly known as uterine cancer.

14 Feb 2020

Universal 'One-Size-Fits-All' Cancer Treatment

Andrew Sewell speaks to News-Medical about his breakthrough research, in which he has discovered a new T-Cell that could treat most cancers.

14 Feb 2020

Immune cells count each other in order to decide whether to attack

A new study published in the journal Nature Communications in February 2020 shows that immune cells consult and coordinate with each other at the site of activity to bring about a balanced but adequate reaction and stave off the threat.

13 Feb 2020

Research reveals novel way to treat cancers using CAR T cell therapy

Too many patients with cancers like multiple myeloma relapse after treatment. This grim reality motivated researchers at Huntsman Cancer Institute at the University of Utah to try to improve the depth and durability of treatment response in multiple myeloma through a new cancer cell targeting mechanism.

10 Feb 2020

CD19 CAR NK cell therapy clinical trial shows encouraging results for hematologic cancers

According to results from a Phase I/IIa trial at The University of Texas MD Anderson Cancer Center, treatment with cord blood-derived chimeric antigen receptor natural killer (NK)-cell therapy targeting CD19 resulted in clinical responses in a majority of patients with relapsed or refractory non-Hodgkin's lymphoma and chronic lymphocytic leukemia, with no major toxicities observed.

6 Feb 2020

Researchers develop an emergency stop switch for CAR T-cell therapies

Immunotherapy, unlike chemotherapy and radiotherapy, arms the body's immune system to attack cancer cells. In recent years, it has proven to be remarkably successful at treating leukemia, lymphoma and other liquid cancers, or cancers present in body fluids.

4 Feb 2020

Ludwig Cancer Research study develops a safer CAR-T therapy

A Ludwig Cancer Research study has devised a new type of chimeric antigen-receptor (CAR) T cell-;a family of promising immunotherapies for cancer- that can be switched on and off on demand.

3 Feb 2020

Researchers develop novel therapeutic approach to cure chronic hepatitis B

Researchers at Helmholtz Zentrum München, Technical University of Munich (TUM) and the German Center for Infection Research have developed a novel therapeutic approach to cure chronic hepatitis B.

3 Feb 2020

HIV antibody therapy improves immune function

A new study published in the journal Nature Medicine in February 2020 reports that the administration of neutralizing antibodies against HIV improve the recipient’s specific T cell responses against the virus.

3 Feb 2020

FDA gives clearance to IND application for Calibr's 'switchable' CAR-T cell therapy

Calibr, the drug discovery and development division of Scripps Research, today announced that the U.S. Food and Drug Administration has given clearance to the Investigational New Drug (IND) application for Calibr's "switchable" CAR-T cell therapy, which is being evaluated for the treatment of certain cancers, including relapsed/refractory B-cell malignancies such as non-Hodgkin lymphoma and chronic lymphocytic leukemia.

3 Feb 2020

Institut Pasteur's scientists isolate strains of coronavirus 2019-nCoV detected in France

As well as sequencing the whole genome of coronavirus 2019-nCoV, the Institut Pasteur continued to work on the samples taken from the first confirmed cases. The quality of these initial samples enabled rapid cell-culture isolation of the new virus.

3 Feb 2020

New discovery could enable scientists to fine-tune activity of cancer-killing immune cells

A discovery by University of North Carolina Lineberger Comprehensive Cancer Center researchers could allow scientists to fine-tune genetically engineered immune cells to heighten their killing power against tumors or to decrease their activity level in the case of severe side effects.

31 Jan 2020

Antigen News and Research

Comprehensive tumor profiling reveals why osteosarcoma does not respond to immunotherapy

Isolating Single T-cells of Interest using an Optofluidic Platform

Bioengineers create light-controllable CAR T cells for cancer immunotherapy

Lengthening prostate cancer screening intervals for men could improve outcomes

Scientists use toxin from rattlesnake venom for chronic pain

UCLA researcher designs ways for immune cells to 'outsmart' solid tumors

Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain

Scientists create world’s first model of pituitary disease using human iPS cells

Study provides a detailed molecular snapshot of endometrial cancer

Universal 'One-Size-Fits-All' Cancer Treatment

Immune cells count each other in order to decide whether to attack

Research reveals novel way to treat cancers using CAR T cell therapy

CD19 CAR NK cell therapy clinical trial shows encouraging results for hematologic cancers

Researchers develop an emergency stop switch for CAR T-cell therapies

Ludwig Cancer Research study develops a safer CAR-T therapy

Researchers develop novel therapeutic approach to cure chronic hepatitis B

HIV antibody therapy improves immune function

FDA gives clearance to IND application for Calibr's 'switchable' CAR-T cell therapy

Institut Pasteur's scientists isolate strains of coronavirus 2019-nCoV detected in France

New discovery could enable scientists to fine-tune activity of cancer-killing immune cells

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