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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Phase I trial evaluates safety, efficacy of astatine for use in alpha therapy for refractory thyroid cancer patients

A research team from the Graduate School of Medicine at Osaka University has started an investigator-initiated clinical trial of sodium astatine ([211At]NaAt) injection for refractory differentiated thyroid cancer patients.

29 Nov 2021

Error rate of bacterial DNA polymerase is consistently higher under microgravity, study shows

On 22 May 2019, scientists from Queen's University boarded a modified Falcon 20 aircraft at Ottawa airport. Scheduled was a 'vomit comet' flight, where the plane repeatedly climbs to 8km in a steep parabola, alternating with a descent in freefall.

29 Nov 2021

The mode of action of essential proteins involved in cancer and Alzheimer´s deciphered

The proteins that belong to the HAT family are essential for life as they transport amino acids across the cell membrane. Although the members of this family are practically identical, some transport certain amino acids and not others.

29 Nov 2021

Study reveals a previously unknown mechanism for pancreatic cancer metastasis

Pancreatic cancer is very aggressive and, unfortunately, has a poor prognosis with a 5-year survival of only 5%. Most deaths related to pancreatic cancer are due to metastasis, which occurs when the tumour invades other organs.

29 Nov 2021

Immunogenicity of modified microparticle-adjuvanted SARS-CoV-2 vaccine

Researchers investigated the immunogenicity of a novel adjuvant comprised of a modified porous silicon microparticle for the SARS-CoV-2 S protein RBD subunit vaccine.

29 Nov 2021

Severe COVID-19 may result in premature aging in recovered patients

As COVID-19 has been found to cause frontal cortex impairment similar to aging, the scientists in a recent study attempted to investigate if severe COVID-19 resulted in aging-related molecular signatures in the brain. The findings from this study are published as a preprint on the medRxiv* server.

28 Nov 2021

Comprehensive genomic study maps the global resurgence of syphilis

The most comprehensive genomic study of syphilis to date has mapped the recent resurgence of the disease around the world.

26 Nov 2021

MIT scientists discover how molecular clusters interact with chromosomes in the nucleus

A cell stores all of its genetic material in its nucleus, in the form of chromosomes, but that's not all that's tucked away in there. The nucleus is also home to small bodies called nucleoli -; clusters of proteins and RNA that help build ribosomes.

25 Nov 2021

Drug-resistant bacteria are quickly outpacing new antibiotic development

Experts predict that without intervention, the problem of multidrug-resistant bacterial infections could be catastrophic by 2050, killing nearly 10 million people each year.

24 Nov 2021

Researchers analyze live bacteria from cystic lesions that are precursors to pancreatic cancer

Bacteria from the digestive system seem to have the potential to cause damage to pancreatic cells, increasing the risk of malignant tumors.

24 Nov 2021

Study uncovers important genetic predispositions for acute myeloid leukemia

The National Center for Tumor Diseases Dresden is a joint institution of the German Cancer Research Center, the University Hospital Carl Gustav Carus Dresden, Carl Gustav Carus Faculty of Medicine at TU Dresden and the Helmholtz-Zentrum Dresden-Rossendorf.

24 Nov 2021

Finding potential biomarkers to predict response to immunotherapy in nonhypermutated cancers

Scientists have discovered a potential biomarker that could more accurately identify which patients with non-hypermutated cancers will respond to specialized immunotherapy drugs called immune checkpoint inhibitors, according to findings published in Science Translational Medicine.

24 Nov 2021

Experimental compound reduces diabetic complications in mice

An experimental compound reduced complications of type 1 and type 2 diabetes in mice—not by lowering blood sugar—but by countering its consequences of cell death, inflammation, and organ damage.

24 Nov 2021

Study explains why moles can change into melanoma

Moles and melanomas are both skin tumors that come from the same cell called melanocytes. The difference is that moles are usually harmless, while melanomas are cancerous and often deadly without treatment.

23 Nov 2021

New virtual reality platform could revolutionize the way single-cell omics data is analyzed

Science has the technology to measure the activity of every gene within a single individual cell, and just one experiment can generate thousands of cells worth of data.

23 Nov 2021

Discovery of a broad-spectrum antiviral activity in self-assembling immunostimulatory duplex RNAs

A new study, published on the bioRxiv* preprint server, has discovered a class of new immunostimulatory RNAs while studying influenza infection-associated host genes in human lung epithelial cells using small interfering RNAs (siRNAs). Scientists revealed that these short duplex RNAs could induce type I and type III interferons (IFN-I/III) in a wide variety of cells.

23 Nov 2021

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

A new study, published on the bioRxiv* preprint server, has focused on public clonotypes, i.e., clones found in multiple individuals, for the development of a novel reverse epitope discovery technique. This technique holds greater potential for population-wide applications.

23 Nov 2021

DNA News and Research

Further Reading

Phase I trial evaluates safety, efficacy of astatine for use in alpha therapy for refractory thyroid cancer patients

Error rate of bacterial DNA polymerase is consistently higher under microgravity, study shows

The mode of action of essential proteins involved in cancer and Alzheimer´s deciphered

Study reveals a previously unknown mechanism for pancreatic cancer metastasis

Immunogenicity of modified microparticle-adjuvanted SARS-CoV-2 vaccine

Severe COVID-19 may result in premature aging in recovered patients

Comprehensive genomic study maps the global resurgence of syphilis

MIT scientists discover how molecular clusters interact with chromosomes in the nucleus

Drug-resistant bacteria are quickly outpacing new antibiotic development

Researchers analyze live bacteria from cystic lesions that are precursors to pancreatic cancer

Study uncovers important genetic predispositions for acute myeloid leukemia

Finding potential biomarkers to predict response to immunotherapy in nonhypermutated cancers

Experimental compound reduces diabetic complications in mice

Study explains why moles can change into melanoma

New virtual reality platform could revolutionize the way single-cell omics data is analyzed

Discovery of a broad-spectrum antiviral activity in self-assembling immunostimulatory duplex RNAs

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

Cryo-EM reveals how the DNA replication machinery assembles at DNA damage sites

Novel carbon dots exhibit antimicrobial activity against gram-negative bacteria

Impact of ultraviolet disinfection on nosocomial transmission of SARS-CoV-2 and other infectious diseases

eBook: Exploring the Cell Cycle and DNA Damage and Repair eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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