Small Molecules News and Research

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Wyss Institute’s eRapid technology licensed to The iQ Group Global

Today, the Wyss Institute for Biologically Inspired Engineering at Harvard University announced that its eRapid technology has been licensed to The iQ Group Global for COVID-19 diagnostic applications.

30 Nov 2020

Minimally invasive technique can help extract dermal interstitial fluid for diagnostic applications

Using an array of tiny needles that are almost too small to see, researchers have developed a minimally invasive technique for sampling a largely unexplored human bodily fluid that could potentially provide a new source of information for routine clinical monitoring and diagnostic testing.

25 Nov 2020

The role of micro-RNA in SARS-CoV-2 infection and COVID-19

A team of researchers based in Iran have explored the role of micro-RNA in COVID-19. Their study titled, “The emerging role of microRNAs in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection,” was published in the latest issue of the journal International Immunopharmacology.

24 Nov 2020

Scientists exploit 'trojan horse' feature in SARS-CoV-2 virus to create antivirals against COVID-19

Scientific analysis of a protein enzyme found in COVID-19 could lead to the development of new drugs to treat the virus, research led by Oxford Brookes University scientists has found.

20 Nov 2020

Raman microscopy-based approach uses gold nanoparticles for visualizing small-molecule drugs

Successful drug development has a significant impact on people's quality of life worldwide. Being able to track how molecules get into target cells, and observing what they do when they are inside, is key to identifying the best candidates.

18 Nov 2020

Scientists reveal new evidence of electrical pathway in the heart

These days having both a land line and a mobile phone seems like overkill. But Virginia Tech researchers have shown that the heart relies on at least two key communication channels to keep abnormal heart rhythms in check.

17 Nov 2020

MIT researchers unravel the molecular structure of key coronavirus protein

MIT chemists have determined the molecular structure of a protein found in the SARS-CoV-2 virus. This protein, called the envelope protein E, forms a cation-selective channel and plays a key role in the virus's ability to replicate itself and stimulate the host cell's inflammation response.

12 Nov 2020

Promising new antivirals target arboviruses and SARS-CoV-2: Nodosome inhibitors

A new study describes two promising small molecules that inhibit a host cell factor, called nucleotide binding oligomerization domain-containing protein 2 (NOD2), that inhibits the replication and spread of many arboviruses. This could lead to the development of broad-spectrum antivirals. The study's findings have been published on the preprint server bioRxiv*.

10 Nov 2020

SARS-CoV-2 RNA genome structure reveals potential targets for development of drugs

The SARS-CoV-2 coronavirus RNA genome structure was studied in detail by researchers from the University of Groningen, the International Institute of Molecular and Cell Biology in Warsaw, and Leiden University.

10 Nov 2020

New therapeutic approach brings hope for treating psoriasis

Disruptive innovations in psoriasis are leading the way at EADV's 29th Congress, EADV Virtual. New data published today shows the first clinical evidence of modulating systemic inflammation by oral delivery of a non-living single strain commensal microbe.

29 Oct 2020

Study findings could lead to a rapid, cost-effective screening tool for COVID-19

A new study from Lawson Health Research Institute, Western University and University of Alberta suggests that COVID-19 affects the human body's blood concentration levels of specific metabolites - small molecules broken down in the human body through the process of metabolism.

27 Oct 2020

Study provides novel biomarkers for predicting rheumatoid arthritis patient responsiveness to DMARDs

A new study led by researchers at Queen Mary University of London provides potential novel biomarkers for predicting patient responsiveness to disease modifying anti-rheumatic drugs (DMARDs).

27 Oct 2020

Scientists identify new therapeutic targets for SARS-CoV-2

To identify new potential therapeutic targets for SARS-CoV-2, a team of scientists at the New York Genome Center, New York University, and the Icahn School of Medicine at Mount Sinai, performed a genome-scale, loss-of-function CRISPR screen to systematically knockout all genes in the human genome.

27 Oct 2020

Small molecules block SARS-CoV-2 spike-ACE2 attachment

The search includes immunological agents, enzyme inhibitors, and soluble competitive inhibitors. Now, a new study published on the preprint server bioRxiv in October 2020 provides preliminary evidence that small molecules can inhibit viral entry by inhibiting spike-ACE2 attachment.

26 Oct 2020

Researchers use molecular dynamics simulations to identify secrets of SARS-CoV-2 virus

The virus wreaking havoc on our lives is an efficient infection machine. Comprised of only 29 proteins (compared to our 400,000), with a genome 1/200,000 the size of ours, SARS-CoV-2 is expertly evolved to trick our cells to contribute its machinery to assist in its propagation.

22 Oct 2020

Small molecule restores normal heart development in animal model with rare genetic disorder

A research team at the Greenwood Genetic Center has successfully used small molecules to restore normal heart and valve development in an animal model for Mucolipidosis II (ML II), a rare genetic disorder. Progressive heart disease is commonly associated with ML II.

15 Oct 2020

Small Molecules News and Research

Wyss Institute’s eRapid technology licensed to The iQ Group Global

Minimally invasive technique can help extract dermal interstitial fluid for diagnostic applications

The role of micro-RNA in SARS-CoV-2 infection and COVID-19

Scientists exploit 'trojan horse' feature in SARS-CoV-2 virus to create antivirals against COVID-19

Raman microscopy-based approach uses gold nanoparticles for visualizing small-molecule drugs

Scientists reveal new evidence of electrical pathway in the heart

MIT researchers unravel the molecular structure of key coronavirus protein

Promising new antivirals target arboviruses and SARS-CoV-2: Nodosome inhibitors

SARS-CoV-2 RNA genome structure reveals potential targets for development of drugs

New therapeutic approach brings hope for treating psoriasis

Study findings could lead to a rapid, cost-effective screening tool for COVID-19

Study provides novel biomarkers for predicting rheumatoid arthritis patient responsiveness to DMARDs

Scientists identify new therapeutic targets for SARS-CoV-2

Small molecules block SARS-CoV-2 spike-ACE2 attachment

Researchers use molecular dynamics simulations to identify secrets of SARS-CoV-2 virus

Small molecule restores normal heart development in animal model with rare genetic disorder

Study reveals why immobilization after injury helps in healing

CHLA investigator receives $3.4 million research grant to study rotavirus vaccine

Findings could bring hope for novel therapeutic strategies against malaria

Scientists refine SARS-CoV-2 protein structures

Shaping the Future of Neuroscience: A Conversation with Atlas Antibodies on the MolBoolean™ and the Impact of SfN 2024

How the Arts Reshape Brain Function: Susan Magsamen on the Future of Neuroaesthetics

Inside the Alzheimer's Association: Dr. Heather Snyder on Driving Research and Collaboration

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