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Interferon selectively kills colon cancer cells when combined with irinotecan chemotherapy agent

Johns Hopkins Kimmel Cancer Center scientists have found that interferon, used for 30 years to treat blood cancers, multiple sclerosis and hepatitis, selectively kills colon cancer cells when combined with another standard chemotherapy agent.

16 Aug 2005

Weight control protein may yield new approaches for treating obesity and type 2 diabetes

The findings in mice further suggest that particular variants of the protein SH2-B might underlie obesity in humans, the researchers said.

16 Aug 2005

Decline in energy production by mitochondria appears to be a key problem leading to insulin resistance

A detectable decline in energy production by mitochondria - the organelles that are the cell's furnace for energy production - seems to be a key problem leading to insulin resistance, and thus to type 2 diabetes, according to studies by Howard Hughes Medical Institute researchers.

16 Aug 2005

New study shows even non-prescription painkillers raise blood pressure in women

According to a new U.S. study women who take higher doses of common, over-the-counter painkillers, such as Ibuprofen and even Tylenol, have higher blood pressure than women who do not.

16 Aug 2005

New hope for those deaf from immune system attack

A new study may one day help those deafened by immune system attack, and possibly also lead to a test that could show which patients may be helped by immediate steroid treatment.

16 Aug 2005

Chronic use of nitroglycerin for chest pain could lead to mitochondrial damage

Definitive evidence to explain how the drug nitroglycerin relieves chest pain has resulted from a new study by Howard Hughes Medical Institute investigators at Duke University Medical Center. Nitroglycerin relaxes blood vessels to boost blood flow, yet the mechanism by which the drug works has remained a matter of scientific controversy.

16 Aug 2005

Oral medications may control symptoms of Type II diabetes in children just as well as insulin injections

According to the medical records of 26 children diagnosed with the disease, oral medications reduced levels of a compound in the blood called hemoglobin A1C by an average of 2 percentage points.

15 Aug 2005

Large-scale computer simulations reveal new insights into antibiotic resistance

Large-scale computer simulations have pinpointed a tiny change in molecular structure that could account for drug resistance in Streptomices pneumoniae, the organism that causes childhood pneumonia and claims 3.5 million lives a year, mainly in developing countries.

15 Aug 2005

Complications from angioplasty much lower among patients whose doctors perform a large number of those procedures each year

Before patients get their clogged heart arteries re-opened, they may want to ask their doctor just how many such procedures he or she has done, a new study finds. The answer may make a big difference in each patient's risk of suffering a major setback before leaving the hospital.

15 Aug 2005

Adalimumab and methotrexate is about five times more effective than methotrexate alone for rheumatoid arthritis

For people with long-standing rheumatoid arthritis, combined treatment with the new "biologic" drug adalimumab and methotrexate is about five times more effective than methotrexate alone, according to a new systematic review of studies.

15 Aug 2005

Abbott receives European approval to market Humira

Abbott has announced that it has received approval from the European Commission to market Humira (adalimumab) as a treatment for psoriatic arthritis and early rheumatoid arthritis (RA) in Europe.

15 Aug 2005

Genomes of Trypanosoma brucei and Trypanosoma cruzi sequenced

Oxford scientists have contributed to the genome sequencing of two parasites which cause major health problems in the developing world.

15 Aug 2005

Key toxin could provide for world's first treatment for Alzheimer's

Dr Karen Cullen at Sydney University’s Institute for Biomedical Research is part of a collaborative team which has identified a key component in the progression of Alzheimer’s disease, a finding which may produce the world’s first effective treatment to combat the debilitating effects of the disease.

15 Aug 2005

FDA places very tight restrictions on acne drug Accutane

The U.S. Food and Drug Administration said late last week, that in future, patients and doctors will have to register with manufacturers and promise to comply with tight restrictions, before using the acne drug Accutane and it's generic versions.

14 Aug 2005

Scientists say valproic acid can eradicate dormant HIV

Early research by scientists in the U.S. suggests that valproic acid could be a potential way to eradicate dormant HIV infections.

14 Aug 2005

Researchers have found a signal that could lead to earlier detection and treatment of ovarian cancer

The Penn State team of scientists led by principal investigator Kathleen M. Mulder, Ph.D., professor of pharmacology, and working in conjunction with a researcher from the Center for Cancer Research, National Cancer Institute in Bethesda, Md., studied "km23," a protein that helps to direct protein traffic in the cell.

13 Aug 2005

Young people in the UK report little difficulty in obtaining cigarettes, alcohol, and other drugs

Reviewing several recent surveys of young people, the authors note that underage smokers can acquire cigarettes easily, often from friends and relatives. Most regular smokers aged 12-15 also say they buy cigarettes from shops.

11 Aug 2005

How some antibiotics kill bacteria

Researchers have uncovered how members of one family of antibiotics kill bacteria that make people sick.

11 Aug 2005

Key step in the production of beta-amyloid

Researchers at UT Southwestern Medical Center have defined a key step in the production of beta-amyloid, a short protein that is thought to be responsible for the development of Alzheimer's disease. Understanding this step may aid in the discovery of drugs that could help block the disease from developing.

11 Aug 2005

Researchers find drug targets for treating metabolic syndrome

Ongoing studies by researchers at UT Southwestern Medical Center and other institutions have uncovered the biochemical basis of many of the factors contributing to what is known as the metabolic syndrome, suggesting potential new drug targets for treating the condition.

11 Aug 2005

Drugs News and Research

Interferon selectively kills colon cancer cells when combined with irinotecan chemotherapy agent

Weight control protein may yield new approaches for treating obesity and type 2 diabetes

Decline in energy production by mitochondria appears to be a key problem leading to insulin resistance

New study shows even non-prescription painkillers raise blood pressure in women

New hope for those deaf from immune system attack

Chronic use of nitroglycerin for chest pain could lead to mitochondrial damage

Oral medications may control symptoms of Type II diabetes in children just as well as insulin injections

Large-scale computer simulations reveal new insights into antibiotic resistance

Complications from angioplasty much lower among patients whose doctors perform a large number of those procedures each year

Adalimumab and methotrexate is about five times more effective than methotrexate alone for rheumatoid arthritis

Abbott receives European approval to market Humira

Genomes of Trypanosoma brucei and Trypanosoma cruzi sequenced

Key toxin could provide for world's first treatment for Alzheimer's

FDA places very tight restrictions on acne drug Accutane

Scientists say valproic acid can eradicate dormant HIV

Researchers have found a signal that could lead to earlier detection and treatment of ovarian cancer

Young people in the UK report little difficulty in obtaining cigarettes, alcohol, and other drugs

How some antibiotics kill bacteria

Key step in the production of beta-amyloid

Researchers find drug targets for treating metabolic syndrome

Drug Discovery - Second Edition eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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