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Screening assays identify TMPRSS2 inhibitors from drug repurposing candidates useful as COVID-19 therapeutic

Researchers used an assay toolset for discovering new transmembrane protease serine 2 inhibiting drug repurposing candidates, that can be useful as therapeutics for COVID-19 treatment.

10 Feb 2022

Clinical severity of COVID-19 caused by SARS-CoV-2 variants and the effectiveness of mRNA vaccines against them

A recent study examined the clinical severity of the SARS-CoV-2 Alpha, Delta, and Omicron VOCs and compared vaccine effectiveness against each VOC.

10 Feb 2022

Neutralizing antibody ABP-310 found to be highly potent against SARS-CoV-2 variants including Omicron

In a new study, a team of researchers described the efficacy of ABP-310, a neutralizing antibody, against SARS-CoV-2 variants, including Omicron.

10 Feb 2022

Properties and pharmacokinetics an oral drug candidate for COVID-19 treatment

Researchers studied the preclinical PK) and in vitro ADME properties of GS-441524, a potential oral drug for COVID-19 treatment.

10 Feb 2022

Study explores protection against Omicron and Delta infections by COVID-19 vaccination and previous infection

A new study demonstrated that infection- and vaccine-induced protection induced by the primary COVID-19 vaccination was much reduced for the Omicron BA.1 infection compared to the Delta infection.

10 Feb 2022

Rapid generation and evaluation of an mRNA vaccine candidate specific to Omicron

A recent study demonstrated the development of a potential SARS-CoV-2 Omicron variant-specific mRNA vaccine candidate.

10 Feb 2022

Scientists identify multi-kinase inhibitors that can effectively block SARS-CoV-2-mediated cytokine release

Researchers investigated the efficacy of two multi-kinase inhibitors, olverembatinib and ponatinib, in inhibiting SARS-CoV-2 omicron-mediated cytokine release in human peripheral blood mononuclear cells.

10 Feb 2022

Protective efficacy of BNT162b2 and Ad26.COV2.S against SARS-CoV-2 Omicron challenge in nonhuman primates

The study highlights the significance of mix-and-match vaccine regimens to diversify the immune responses against highly mutated variants of SARS-CoV-2 such as Omicron.

10 Feb 2022

The effect of Omicron mutations at the fundamental atomic scale level

The present study provided interesting insights into the interactions of AAs at the interface between SARS-CoV-2 spike and human ACE2 receptors.

10 Feb 2022

Comparison of SARS-CoV-2 test performance by sample type and modality in close contacts of SARS-CoV-2 cases

In this study, researchers looked at how well molecular and antigen testing performed in symptomatic and asymptomatic close contacts of SARS-CoV-2 positive people.

10 Feb 2022

Omicron resists antibodies, causes less severe disease than previous SARS-CoV-2variants

In two recent studies, researchers at Washington University School of Medicine in St. Louis found evidence that the omicron variant of the virus that causes COVID-19 causes less severe disease than previous variants — at least in rodents — but that many antibody-based therapies may not be effective against it.

10 Feb 2022

Measuring T cell responses to SARS-CoV-2 vaccination and infection in healthcare workers with two different assays

The purpose of this study was to compare the OI TSPOT with the in-house PITCH ELISpot for reporting T cell responses specific to SARS-CoV-2 spike and structural proteins.

10 Feb 2022

Regular surveillance testing of a community can prevent Covid-19 outbreaks

Covid-19 is often asymptomatic and can lead infected individuals to spread the disease without knowing it. Yet, regular surveillance testing of a community can catch these cases and prevent outbreaks.

10 Feb 2022

Study tests efficacy of molnupiravir against SARS-CoV-2 VOCs in various animal models

A study published on the bioRxiv* preprint server evaluates molnupiravir against a panel of relevant VOCs using three efficacy models: primary human airway epithelium organoids, a ferret model of upper respiratory disease, and a Roborovski dwarf hamster model for severe COVID-19.

9 Feb 2022

Machine learning highly effective at identifying SARS-CoV-2 variants

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9 Feb 2022

Wearable devices can help monitor wellness during recovery from COVID-19

Researchers compare the resting heart changes in individuals with COVID-19 with individuals diagnosed with seasonal influenza.

9 Feb 2022

Researchers identify a potent new combination of antiviral drugs to combat SARS-CoV-2

The recent success of Paxlovid has encouraged researchers to develop new anti-covid drugs. With this in mind, scientists from the University of Pennsylvania have been investigating a new synergistic treatment. Their research is released early as an unedited version of the manuscript to be published in the journal Nature.

9 Feb 2022

SARS News and Research

Screening assays identify TMPRSS2 inhibitors from drug repurposing candidates useful as COVID-19 therapeutic

Clinical severity of COVID-19 caused by SARS-CoV-2 variants and the effectiveness of mRNA vaccines against them

Neutralizing antibody ABP-310 found to be highly potent against SARS-CoV-2 variants including Omicron

Properties and pharmacokinetics an oral drug candidate for COVID-19 treatment

Study explores protection against Omicron and Delta infections by COVID-19 vaccination and previous infection

Rapid generation and evaluation of an mRNA vaccine candidate specific to Omicron

Scientists identify multi-kinase inhibitors that can effectively block SARS-CoV-2-mediated cytokine release

Protective efficacy of BNT162b2 and Ad26.COV2.S against SARS-CoV-2 Omicron challenge in nonhuman primates

The effect of Omicron mutations at the fundamental atomic scale level

Comparison of SARS-CoV-2 test performance by sample type and modality in close contacts of SARS-CoV-2 cases

Omicron resists antibodies, causes less severe disease than previous SARS-CoV-2variants

Measuring T cell responses to SARS-CoV-2 vaccination and infection in healthcare workers with two different assays

Regular surveillance testing of a community can prevent Covid-19 outbreaks

Study tests efficacy of molnupiravir against SARS-CoV-2 VOCs in various animal models

Machine learning highly effective at identifying SARS-CoV-2 variants

Wearable devices can help monitor wellness during recovery from COVID-19

Researchers identify a potent new combination of antiviral drugs to combat SARS-CoV-2

Super-resolution imaging of the human coronavirus genome during infection

Newborn antibodies following maternal COVID-19 vaccination persist for up to six months

The serious risks COVID-19 may pose during pregnancy

Shaping the Future of Neuroscience: A Conversation with Atlas Antibodies on the MolBoolean™ and the Impact of SfN 2024

How the Arts Reshape Brain Function: Susan Magsamen on the Future of Neuroaesthetics

Inside the Alzheimer's Association: Dr. Heather Snyder on Driving Research and Collaboration

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