Mortality News and Research

RSS

“Cognitive clock” emerges as a new way to measure brain health

Researchers have developed a novel method to monitor the brain health of patients to improve the early diagnosis and treatment of certain diseases.

2 Jun 2021

Women who experience acute aortic dissection are more likely to die than men, shows study

Women who experience acute aortic dissection-;a spontaneous and catastrophic tear in one of the body's main arteries-;not only are older and have more advanced disease than men when they seek medical care, but they also are more likely to die, according to research published online today in The Annals of Thoracic Surgery.

2 Jun 2021

Positive COVID-19 screening test helps monitor respiration rate, blood-oxygen saturation at home

Two easily measurable signs of health -; respiration rate and blood-oxygen saturation -; are distinctly predictive of higher mortality among patients hospitalized with COVID-19, according to a study examining the cases of inpatients with COVID-19 at Rush University Medical Center and University of Washington Medicine hospitals.

2 Jun 2021

Mice study shows that Western diet can lead to NASH, liver fibrosis

Apart from lifestyle interventions, there are currently no approved treatments for NASH. A liver transplant is sometimes the only remedy.

2 Jun 2021

Study reveals infections by Histoplasma fungus as major cause of death in people with HIV

A series of autopsies performed in an infectious disease hospital in the Brazilian Amazon reveals that infections by the Histoplasma fungus are a major cause of death in people with HIV.

1 Jun 2021

Antibody cocktail effectively inhibits SARS-CoV-2 in the rhesus macaque model

Researchers from the US tested the prophylactic potential of a combination of 2 mAbs administered 3 or 75 days before respiratory challenge in rhesus macaques. They used the rhesus macaque model to test the added benefit of combinatory parenteral administration of 2 high-affinity anti-SARS-CoV-2 mAbs - C144-LS and C135-LS. These mAbs were developed to neutralize the virus and tweaked to improve their pharmacokinetics.

1 Jun 2021

ALG-097111 potently inhibits SARS-CoV-2 replication in Syrian Hamster model in vivo

A team of researchers from the US and Belgium applied a structure-based approach with early monitoring of cathepsin L inhibition along with SARS-CoV-2 3CLpro inhibition. They identified a potent and selective SARS-CoV-2 3CLpro inhibitor, ALG-097111, which has proven activity against SARS-CoV-2 in SARS-CoV-2 hamster models in vivo. This study is published in the journal, Biochemical and Biophysical Research Communications.

1 Jun 2021

Study offers longitudinal roadmap of immune activation and resolution in mild COVID-19

Researchers from the US recently profiled the longitudinal immune response in mild COVID-19 patients starting with early time points of 1-15 days post-infection through convalescence to over 100 days after onset of symptoms.

1 Jun 2021

Overweight or obesity amplifies harmful effects of alcohol on the liver

Led by the University of Sydney's Charles Perkins Centre, the study looked at medical data from nearly half a million people and found having overweight or obesity considerably amplified the harmful effects of alcohol on liver disease and mortality.

1 Jun 2021

Using Sotrovimab to treat COVID-19 early

A new study published on the medRxiv* preprint server hypothesized that a monoclonal antibody that has the capability to neutralize all sarbecoviruses could also be used to target a highly conserved epitope. This conserved sequence has a high probability of remaining unchanged in SARS-CoV-2 variants.

31 May 2021

COVID-19 had claimed more than 3 million lives worldwide in 2020

By the end of 2020, COVID-19 had claimed the lives of more than three million people worldwide, representing 1.2 million more deaths than officially reported earlier, says a newly released report by the World Health Organization (WHO).

31 May 2021

More than a third of heat-related deaths attributable to human-induced global warming

Between 1991 and 2018, more than a third of all deaths in which heat played a role were attributable to human-induced global warming, according to a new article in Nature Climate Change.

31 May 2021

COVID-19, mass testing and the utility of wastewater epidemiology

In a recent study, researchers developed a methodology to detect SARS-CoV-2 RNA in wastewater with the potential for finding an association between the wastewater treatment plant (WWTP) SARS-CoV-2 influent viral RNA load and COVID-19 cases in the community. This study indicates that a national scale wastewater-based epidemiology can play a role in COVID-19 surveillance.

31 May 2021

Different early antibody responses define COVID-19 disease trajectory

In a new study posted to the bioRxiv* preprint server, a prospective cohort of patients with COVID-19 exhibited distinct features of the IgG fragment antigen-binding (Fab) and fragment crystallizable (Fc) domains, predicting two distinct disease trajectory two days after a positive test.

31 May 2021

Novel protein interactions with ACE2 disrupted by SARS-CoV-2, contributes to COVID-19 pathologies

A severe and often fatal immune response called a “cytokine storm” can occur following SARS-CoV-2 infection. Some patients suffer from a range of complications several months after testing negative for SARS-CoV-2, and this is called ‘Long Haul’ or ‘Long’ COVID-19. The causes behind this phenomenon are not well understood.

31 May 2021

Neuropathology of COVID-19 patients caused by infection of brain pericytes

Recently, researchers from the UK and Sweden used highly sensitive multiplexed immunohistochemistry to study the brain tissue of COVID-19 patients and controls to analyze ACE2 expression in brain pericytes of patients with neurological symptoms. They also used spatial immunophenotyping to assess inflammation in brain tissue of COVID-19 patients.

31 May 2021

Researchers review 50 years of progress in women's health

Debates over women's health have long been contentious, but have also resulted in significant improvements in areas like equitable access to health care and survivorship. But the overall picture remains far from perfect.

31 May 2021

Researchers assess the prognostic value of cardiac troponin I in COVID-19 patients

Corona Virus Disease (COVID -19) patients primarily appear with respiratory issues and viral pneumonia. The patients may also present cardiovascular issues includes early signs of acute myocardial injury.

29 May 2021

FDA approves targeted therapy for tumors with KRAS mutations

Today, the U.S. Food and Drug Administration approved Lumakras (sotorasib) as the first treatment for adult patients with non-small cell lung cancer whose tumors have a specific type of genetic mutation called KRAS G12C and who have received at least one prior systemic therapy.

29 May 2021

FDA seeks $6.5 billion for investments in core food safety, critical public health infrastructure

The U.S. Food and Drug Administration is requesting a total budget of $6.5 billion as part of the President's fiscal year (FY) 2022 budget - a nearly 8% ($477 million) increase over the agency's FY 2021 funding level for investments in critical public health infrastructure, core food safety and medical product safety programs and other vital public health programs.

29 May 2021

Mortality News and Research

“Cognitive clock” emerges as a new way to measure brain health

Women who experience acute aortic dissection are more likely to die than men, shows study

Positive COVID-19 screening test helps monitor respiration rate, blood-oxygen saturation at home

Mice study shows that Western diet can lead to NASH, liver fibrosis

Study reveals infections by Histoplasma fungus as major cause of death in people with HIV

Antibody cocktail effectively inhibits SARS-CoV-2 in the rhesus macaque model

ALG-097111 potently inhibits SARS-CoV-2 replication in Syrian Hamster model in vivo

Study offers longitudinal roadmap of immune activation and resolution in mild COVID-19

Overweight or obesity amplifies harmful effects of alcohol on the liver

Using Sotrovimab to treat COVID-19 early

COVID-19 had claimed more than 3 million lives worldwide in 2020

More than a third of heat-related deaths attributable to human-induced global warming

COVID-19, mass testing and the utility of wastewater epidemiology

Different early antibody responses define COVID-19 disease trajectory

Novel protein interactions with ACE2 disrupted by SARS-CoV-2, contributes to COVID-19 pathologies

Neuropathology of COVID-19 patients caused by infection of brain pericytes

Researchers review 50 years of progress in women's health

Researchers assess the prognostic value of cardiac troponin I in COVID-19 patients

FDA approves targeted therapy for tumors with KRAS mutations

FDA seeks $6.5 billion for investments in core food safety, critical public health infrastructure

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Exploring the G:Box and for high-quality imaging

Latest News