Small Molecules News and Research

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Forgetful? Look at the time

An interesting new paper describes the discovery of a gene in mice that affects the degree of memory recall at various times of day. They found that this gene makes mice most forgetful at the time immediately before they wake.

18 Dec 2019

Targeting specific nuclear transport systems may lead to possible therapeutic strategies for cancer

Although less often the focus of cancer research, recent studies have hinted at the possible importance of a type of protein known as nuclear transport receptors.

17 Dec 2019

Study shows how immune cells quickly switch to attack mode

Macrophages have two faces: In healthy tissue, they perform important tasks and support their environment. However during an infection, they stop this work and hunt down the pathogens instead.

17 Dec 2019

Researchers develop 'scar in a dish' model to closely mimic progressive organ scarring

Every organ in the body is capable, to some extent, of repairing itself after an injury. As part of this process, scar tissue forms and then recedes to make room for normal tissue when healing is complete.

11 Dec 2019

ADDF announces new awards through its Diagnostics Accelerator initiative

The Alzheimer's Drug Discovery Foundation announced six new investments totaling $6 million through its Diagnostics Accelerator initiative.

4 Dec 2019

New method for discovering potential cancer-treating compounds

A new study published in the journal Cell Reports reports a novel method by which antitumor drugs that focus on reawakening exhausted immune cells called cytotoxic T cells against cancer can be quickly identified. This could help treat a large subset of cancers that thrive because of their ability to suppress antitumor activity in T cells.

4 Dec 2019

Academia-Industry Partnership Leads Innovative New Approach to Alternative Dental Filling Material

A medical device case study: UCL researchers and dental materials manufacturer collaborate to speed up the development of a new dental filling material for children.

2 Dec 2019

ICR scientists carry out first comprehensive assessment of chemical probe resources

A new report urges biomedical researchers to use online web resources very carefully, taking into account their complementary benefits and weaknesses, when selecting small-molecule chemical probes to help answer their research questions.

28 Nov 2019

UCLA scientists discover link between a protein and human blood stem cell self-renewal

UCLA scientists have discovered a link between a protein and the ability of human blood stem cells to self-renew. In a study published today in the journal Nature, the team reports that activating the protein causes blood stem cells to self-renew at least twelvefold in laboratory conditions.

27 Nov 2019

New theranostic reagent could improve detection and treatment of prostate cancer

A recently discovered prostate cancer-selective antigen has been identified as a useful molecular imaging target for the detection and targeting of metastatic prostate cancer lesions, as reported in the November issue of The Journal of Nuclear Medicine.

27 Nov 2019

Key mechanism identified for how antiviral immune responses reprogram liver metabolism

Researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences identified a key mechanism for how antiviral immune responses reprogram liver metabolism. Their recent study, which was published in the renowned scientific journal Immunity, investigated the communication between inflammation and liver metabolism during chronic viral infection.

26 Nov 2019

Research yields potent antimicrobial that works against staph infection

Research led by scientists from McMaster University has yielded a potent antimicrobial that works against the toughest infectious disease strains. The find could be the beginning of developing new therapeutics to combat drug-resistant infections.

25 Nov 2019

Potent antimicrobial could combat antibiotic-resistant MRSA infections

Scientists have discovered a strong antimicrobial that is effective against some of the strongest infectious diseases.

25 Nov 2019

TACC announces role as key collaborator in NIH grant to study chronic pain and opioid dependence

Pain impacts nearly every individual at some point in their lives. With more than 25 million adults in the U.S. experiencing daily pain, the U.S. is facing a crisis due to the high prevalence of chronic pain and associated opioid use disorder and overdose deaths.

14 Nov 2019

Liposomes cross blood brain barrier, could get healing drugs to stroke-affected brain

A new study from University of Manchester researchers, published in ACS Neuro, shows a high possibility of treating stroke patients using very small cell sacs called liposomes to bypass the blood brain barrier and carry lifesaving drugs to the brain to prevent damage following a stroke.

7 Nov 2019

Exercise causes changes to some of the body's metabolites, research finds

New research finds that exercise causes changes to some of the body's metabolites-;small molecules the body produces during metabolism.

7 Nov 2019

Penn researchers tag CAR T cells with imaging markers to monitor cancer therapy

With CAR T cell therapy, a patient's own immune cells are genetically modified and inserted back into the body to find and kill cancer. This form of immunotherapy has already revolutionized some cancer treatments, but once the CAR T cells are inside a patient, where do they go? How do doctors know that they have successfully reached their target and that they are continuing to fight disease weeks, months, or even years later?

5 Nov 2019