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Research identifies the third day of hospitalization as a tipping point in progression of COVID-19 pneumonia

New research being presented at this year's European Congress of Clinical Microbiology & Infectious Diseases in Lisbon, Portugal, (23-26 April), has identified the third day of hospitalization as a tipping point in the progression of disease among symptomatic patients admitted for COVID-19 pneumonia.

23 Apr 2022

The diversity of transcriptional targets between four different coronavirus nsp1 proteins

Researchers investigated variations in the host immune response-elicited by non-structural protein 1 of coronaviruses.

22 Apr 2022

Study suggests SARS-CoV-2 is undergoing evolutionary changes at the functional RNA level in addition to the amino acid level

Researchers demonstrated SARS-CoV-2 evolution at the transcriptional level.

22 Apr 2022

Study demonstrates that a low-dose, bivalent, unmodified mRNA vaccine against SARS-CoV-2 is highly efficacious

Researchers compared the efficiency of monovalent and bivalent mRNA vaccines against SARS-CoV-2.

22 Apr 2022

Discovering Genetic Variants that Significantly Predispose People to Critical COVID-19

We speak with postdoctoral researcher Erola Pairo-Castineira about her recent work which aimed to find the genetic factors that may predispose individuals to critical COVID-19 and learn how COVID-19 affects cells in the body.

22 Apr 2022

Intranasal nanoparticle STING agonist with immunoantiviral activity against SARS-CoV-2 variants

Researchers developed an immunoantiviral, NanoSTING, and demonstrated its broad-spectrum antiviral properties in hamsters and mice.

21 Apr 2022

Study explores SARS-CoV-2 Omicron variant and infected colon epithelial cells

In a new study, researchers assessed the impact of the SARS-CoV-2 Omicron variant on infected human cells and organs.

20 Apr 2022

Study demonstrates subset of vaccine-induced HLA-A*24:02-restricted T cells exhibits enhanced reactivity against the Omicron BA.1 variant

Researchers characterized vaccine-induced T cell response specific for spike proteins of several SARS-CoV-2 variants.

20 Apr 2022

Persistent loss of smell after COVID-19 associated with altered olfactory epithelial gene expression

Researchers performed histology of the olfactory epithelium for smell loss measurements in patients with post-acute sequelae of SARS-CoV-2 infection.

20 Apr 2022

Study evaluates the ocular tropism and the possible ocular transmission of SARS-CoV-2 in animal models

Researchers demonstrated ocular tropism of SARS-CoV-2 through neuronal invasion in transgenic mice with hACE2 expression.

20 Apr 2022

Study reveals a complexity to how the body "regulates the regulators" of the immune system

Checkpoint inhibitors have become important tools in the cancer-fighting arsenal. By blocking proteins that normally restrain the immune response, these drugs can help the immune system destroy cancer cells.

20 Apr 2022

Type I interferon found to be major driver of memory, cognitive loss in Alzheimer's disease mouse model

Alzheimer's disease (AD), the most common type of dementia, progressively impairs memory, concentration and the ability to learn new things and accomplish everyday activities.

19 Apr 2022

Researchers discover a novel signaling pathway that defines interferon responses in blood cancers

Northwestern Medicine investigators have discovered a novel signaling pathway activated by interferons, a group of immune system proteins, that suppresses the anti-tumor response of interferons in patients with a particular type of blood cancer, according to findings published in Nature Communications.

19 Apr 2022

The involvement of the skeletal muscles in long COVID-19

Researchers reviewed the mechanisms of muscle tissue injury, aggravating conditions, and associated sequelae in long COVID‐19.

18 Apr 2022

Avasimibe inhibits SARS-CoV-2 and boosts T-cell responses

Researchers demonstrate that avasimibe-mediated inhibition of ACAT blocks the entry and fusion of SARS-CoV-2 in different cell types.

18 Apr 2022

Role of cGAS-STING in SARS-CoV-2 infection

A new study analyzes the activation of cGAS and STING can induce a type I IFN response due to SARS-CoV-2 infection.

15 Apr 2022

The preclinical potential of S. miltiorrhiza extracts for the treatment of COVID-19

In a recent study, researchers assessed the anti-COVID-19 efficacy of Salvia miltiorrhiza Bunge.

14 Apr 2022

Novel transdermal vaccine delivery for COVID-19 and cancer

Researchers assess the efficacy of a fluorocarbon modified chitosan system for the development of SARS-CoV-2 vaccines and tumor immunotherapy.

13 Apr 2022

People with COVID-19 can shed viral RNA in their feces months after initial infection

The extended presence of viral RNA in feces, but not respiratory samples, along with the association of fecal viral RNA shedding with GI symptoms suggest that SARS-CoV-2 infects the GI tract, and that this infection can be prolonged in a subset of individuals with COVID-19.

13 Apr 2022

The molecular context and substrate profiles of human cell surface receptor tyrosine kinases

researchers discussed and identified the systemic functions and interactions of 52 active cell surface receptor tyrosine kinases, providing insights on RTK-RTK interactions and substrates, RTK-protein complexes, and signaling pathways.

13 Apr 2022

Interferon News and Research

Research identifies the third day of hospitalization as a tipping point in progression of COVID-19 pneumonia

The diversity of transcriptional targets between four different coronavirus nsp1 proteins

Study suggests SARS-CoV-2 is undergoing evolutionary changes at the functional RNA level in addition to the amino acid level

Study demonstrates that a low-dose, bivalent, unmodified mRNA vaccine against SARS-CoV-2 is highly efficacious

Discovering Genetic Variants that Significantly Predispose People to Critical COVID-19

Intranasal nanoparticle STING agonist with immunoantiviral activity against SARS-CoV-2 variants

Study explores SARS-CoV-2 Omicron variant and infected colon epithelial cells

Study demonstrates subset of vaccine-induced HLA-A*24:02-restricted T cells exhibits enhanced reactivity against the Omicron BA.1 variant

Persistent loss of smell after COVID-19 associated with altered olfactory epithelial gene expression

Study evaluates the ocular tropism and the possible ocular transmission of SARS-CoV-2 in animal models

Study reveals a complexity to how the body "regulates the regulators" of the immune system

Type I interferon found to be major driver of memory, cognitive loss in Alzheimer's disease mouse model

Researchers discover a novel signaling pathway that defines interferon responses in blood cancers

The involvement of the skeletal muscles in long COVID-19

Avasimibe inhibits SARS-CoV-2 and boosts T-cell responses

Role of cGAS-STING in SARS-CoV-2 infection

The preclinical potential of S. miltiorrhiza extracts for the treatment of COVID-19

Novel transdermal vaccine delivery for COVID-19 and cancer

People with COVID-19 can shed viral RNA in their feces months after initial infection

The molecular context and substrate profiles of human cell surface receptor tyrosine kinases

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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