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Study confirms coronavirus RNA synthesis occurs inside membrane-bound compartments

Researchers have experimentally proved that virus-related double-stranded RNA (dsRNA) and the sites of viral RNA synthesis are associated with one another.

22 Dec 2021

Transcription factor Blimp1 identified as potential target for modulating T-reg activity to treat cancer

In cancer, a major obstacle to anti-tumor immunity and immunotherapy treatment is the infiltration of regulatory T cells, or T-reg cells, into a tumor. These immune cells generally turn down the immune response, and they can prevent the immune system from destroying cancer cells.

22 Dec 2021

Impact of acute kidney injury associated gene expression in human kidney cells

A new study attempts to perform a comparative single-cell census of human kidneys employing samples from individuals suffering from acute kidney injury and controls without the condition.

20 Dec 2021

Study says COVID mRNA-based vaccines best for booster vaccination

A new study looks at the adaptive immune response to COVID-19 vaccines, wherein the authors compare heterologous to homologous immunization.

19 Dec 2021

SARS-CoV-2 VOCs dependent on IFITM2 for efficient infection establishment

Researchers demonstrate that the Alpha, Beta, Gamma, and Delta variants of SARS-CoV-2 require endogenous IFITM2 expression for efficient replication.

15 Dec 2021

Correlation between idiopathic pulmonary fibrosis and COVID-19

A new study investigates the genetic overlap between COVID-19 and idiopathic pulmonary fibrosis to identify possible shared biological mechanisms.

14 Dec 2021

New mRNA vaccine platform provides stronger protection against SARS-CoV-2 delta variant

A group of researchers from various institutions developed a nucleoside-modified mRNA vaccine that encodes the SARS-CoV-2 N protein (mRNA-N) and is formulated in lipid nanoparticles for this investigation (LNP).

14 Dec 2021

Determination of the effectiveness of COVID-19 vaccination using T cell receptor repertoire

A new study published on the bioRxiv preprint server has hypothesized that T cell receptors (TCR) repertoire can measure the response to vaccines, as it would identify the TCR of clones that respond to the vaccination.

13 Dec 2021

Impact of tumor environments on susceptibility and course of disease in those infected with SARS-CoV-2

A review assessed the impact of "hot" vs. "cold" immune/tumor environments (and associated therapies) on susceptibility and disease course in subjects with these two types of tumors and infected with SARS-CoV-2 to decipher the mechanisms that drive these adverse outcomes in COVID-19 infected cancer patients.

13 Dec 2021

Bioinformatics pipeline can be used to quickly identify SARS-CoV-2 therapeutics

In a new study, researchers developed a bioinformatics pipeline that uses RNA sequencing data to identify altered genes and signaling pathways affected by viral infection.

13 Dec 2021

Study demonstrates SARS-CoV-2 ORF6 localization and interferon antagonism as independent events

Researchers deploy mutagenesis studies to investigate the relationship between ORF6 localization and IFN antagonism.

12 Dec 2021

Statistical model builds SARS-CoV-2 interactome with miRNAs, protein-coding genes, and co-infecting microbes

A team of researchers recently developed a statistical modeling method known as multiple-layer crosstalk (MLCrosstalk).

12 Dec 2021

Brain injury markers associated with dysregulated immunological responses in COVID-19

Study shows that during hospitalization, patients with COVID-19 demonstrated elevated NfL and GFAP in a severity-dependant manner, as well as evidence of ongoing active brain injury 4 months later.

8 Dec 2021

Lunaphore highlights novel spatial biology research at SITC 2021

Lunaphore today announced new research from collaborators at the University of Birmingham.

From Lunaphore 7 Dec 2021

Immune response of Pfizer vaccinees who received Moderna or Pfizer booster

A new preprint discusses the immune boost resulting from homologous or heterologous booster doses in individuals fully vaccinated with two doses of the Pfizer vaccine.

7 Dec 2021

Scientists develop and characterize variant-specific vaccines against SARS-CoV-2

In a recent study conducted at Yale University, USA, scientists have investigated the immunogenicity of mRNA-based coronavirus disease 2019 (COVID-19) vaccine candidates encoding the spike proteins of different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. The findings reveal that the vaccines induce robust immune responses against SARS-CoV-2 variants. The study is currently available on the bioRxiv* preprint server.

6 Dec 2021

Interferon News and Research

Study confirms coronavirus RNA synthesis occurs inside membrane-bound compartments

Transcription factor Blimp1 identified as potential target for modulating T-reg activity to treat cancer

Impact of acute kidney injury associated gene expression in human kidney cells

Study says COVID mRNA-based vaccines best for booster vaccination

SARS-CoV-2 VOCs dependent on IFITM2 for efficient infection establishment

Correlation between idiopathic pulmonary fibrosis and COVID-19

New mRNA vaccine platform provides stronger protection against SARS-CoV-2 delta variant

Determination of the effectiveness of COVID-19 vaccination using T cell receptor repertoire

Impact of tumor environments on susceptibility and course of disease in those infected with SARS-CoV-2

Bioinformatics pipeline can be used to quickly identify SARS-CoV-2 therapeutics

Study demonstrates SARS-CoV-2 ORF6 localization and interferon antagonism as independent events

Statistical model builds SARS-CoV-2 interactome with miRNAs, protein-coding genes, and co-infecting microbes

Brain injury markers associated with dysregulated immunological responses in COVID-19

Lunaphore highlights novel spatial biology research at SITC 2021

Immune response of Pfizer vaccinees who received Moderna or Pfizer booster

Scientists develop and characterize variant-specific vaccines against SARS-CoV-2

Simple quantitative framework to understand the pathogenesis of severe COVID-19

Meth use and intimate partner violence drive exhaustion of immune cells in HIV patients

New approach to COVID-19 immune profiling using blood-based machine learning

Study explores the emergence and spread of SARS-CoV-2 Delta variant across Brazil

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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