Oxidative Stress News and Research

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Oxidative Stress is a condition in which antioxidant levels are lower than normal. Antioxidant levels are usually measured in blood plasma.

Fasting-mimicking diet plus vitamin C could be effective at treating some cancer types

Scientists from USC and the IFOM Cancer Institute in Milan have found that a fasting-mimicking diet could be more effective at treating some types of cancer when combined with vitamin C.

12 May 2020

Indo-Mediterranean style diets can cause decline in pre-heart failure, arrhythmias

The role of diets in the pathogenesis of cardiac dysfunction is controversial. However, it is well known that Western diet causes oxidative stress and has pro-inflammatory effects, whereas Mediterranean style diets are anti-inflammatory.

11 May 2020

Simple molecular reagents to fight against neurodegenerative disorders

Sometimes the most complex problems actually have very simple solutions. A group of South Korean researchers reported an efficient and effective redox-based strategy for incorporating multiple functions into simple molecular reagents against neurodegenerative disorders.

11 May 2020

Link found between blood vessel inflammation and abnormalities in mitochondrial fission

The vast majority of cells in the human body contain tiny power plants known as mitochondria that generate much of the energy cells use for day-to-day activities.

11 May 2020

New compound significantly reduces multiple pathologies linked to Alzheimer's disease

When tested in brain cells and in a mouse model of Alzheimer's disease, a new compound significantly reduced the number of amyloid plaques in the brain, lessened brain inflammation and diminished other molecular markers of the disease.

8 May 2020

Harmful effects of BPA can be reversed by administering coenzyme Q10

Exposure to bisphenol A (BPA), an industrial chemical used to make certain plastics and resins, inner coatings for food cans and bottle tops, thermal paper used in store receipts, dental sealants and so on, is a concern because of possible adverse health effects, including a reduction in fertility.

7 May 2020

Study investigates potential use of metal catalysts to create drug discovery platform

The use of metals in drug delivery could offer major benefits, including allowing for lower dosages of a medication to achieve therapeutic effects.

6 May 2020

New clinical trial to assess whether hypertension drug may reduce COVID-19 severity

Researchers at University of California San Diego School of Medicine have launched a clinical trial to investigate whether a drug approved for treating high blood pressure, heart failure and diabetic kidney disease might also reduce the severity of COVID-19 infections, lowering rates for intensive care unit admissions, the use of mechanical ventilators and all-cause mortality.

30 Apr 2020

Breastfeeding helps reduce the risk of maternal postpartum diabetes

A team of South Korean researchers found that lactation can lower the incidence and reduce the risk of maternal postpartum diabetes.

29 Apr 2020

Investigational drug may hold benefit for patients with lung and ovarian cancers

In a first-time disclosure of IPN60090, a small-molecule inhibitor of the metabolic enzyme glutaminase (GLS1), researchers from The University of Texas MD Anderson Cancer Center's Therapeutics Discovery division and Ipsen Biopharmaceuticals reported the preclinical discovery and early-stage clinical development of this novel drug. IPN60090, now under investigation in a Phase I trial, may hold benefit for certain patients with lung and ovarian cancers.

27 Apr 2020

Prenatal exposure to air pollutants is linked with growth delays

Prenatal exposure to air pollution has been linked to various adverse effects on children's health, including lower birth weight and respiratory and neurodevelopmental problems.

23 Apr 2020

Air pollution, dementia, and cardiovascular disease

A new study published in March 2020 in the journal JAMA Neurology shows an association between air pollution and the development of dementia. However, the role played by cardiovascular disease (CVD) is yet to become apparent.

21 Apr 2020

A new, potential treatment for nonalcoholic steatohepatitis with fibrosis

In the 2020 April 21 issue of Journal of Hepatology, a research group from the Department of Hepatology in Osaka City University Graduate School of Medicine, Japan reported that a new insight into the pathophysiology of human nonalcoholic steatohepatitis (NASH) with fibrosis and suggested a possibility of the new therapy using cytoglobin (CYGB) inducer for clinical application.

21 Apr 2020

Role of ACE/ARB inhibitors in the treatment of COVID-19

A new opinion piece published in the journal Circulation Research in April 2020 defends the use of antihypertensive drugs called ACE inhibitors and ARBs in patients with pandemic viral pneumonia called COVID-19.

20 Apr 2020

Do ACE inhibitors increase SARS-CoV-2 binding to ACE2?

The COVID-19 pandemic has forced clinicians and academicians to intensive research to find evidence for many conventional therapies. A new round-up editorial published in the journal Cardiovascular Research in April 2020 summarizes the current clinical grounds for and against the use of the commonly used angiotensin axis inhibitors in patients with COVID-19.

20 Apr 2020

Smoking doubles risk of severe COVID-19 disease

The fatality rate among infected people increases among the elderly and those with underlying medical conditions. Now, a new study published as a pre-print on medXriv, links smoking to the progression of COVID-19 disease, suggesting that the odds of disease progression is more than double in smokers.

20 Apr 2020

Toxic cell atlas can guide discovery of new drugs for neurodegeneration

A common thread in many inflammatory and neurodegenerative diseases, including multiple sclerosis (MS), is damage caused by oxidative stress. Oxidative stress occurs when cells produce toxic substances known as reactive oxygen species, which are damaging nerve cells and other cells in the body.

13 Apr 2020

Short-term exposure to even low levels of air pollution can affect gene expression

New data from a landmark study done by Monash University researchers in Australia raises significant concerns that even short-term exposure to low level air pollution can affect gene expression, leaving us at risk of other diseases such as cancer, cardiovascular and respiratory diseases.

8 Apr 2020

DsbA-L gene may play a role in protecting respiratory function of the elderly

The lungs are constantly exposed to the external environment and maintain homeostasis by adapting to stress and tissue damage.

6 Apr 2020

Study unravels antibacterial effects of nanopillars in insect wings

Some insect wings such as cicada and dragonfly possess nanopillar structures that kill bacteria upon contact. However, to date, the precise mechanisms that cause bacterial death have been unknown.

6 Apr 2020

Oxidative Stress News and Research

Further Reading

Fasting-mimicking diet plus vitamin C could be effective at treating some cancer types

Indo-Mediterranean style diets can cause decline in pre-heart failure, arrhythmias

Simple molecular reagents to fight against neurodegenerative disorders

Link found between blood vessel inflammation and abnormalities in mitochondrial fission

New compound significantly reduces multiple pathologies linked to Alzheimer's disease

Harmful effects of BPA can be reversed by administering coenzyme Q10

Study investigates potential use of metal catalysts to create drug discovery platform

New clinical trial to assess whether hypertension drug may reduce COVID-19 severity

Breastfeeding helps reduce the risk of maternal postpartum diabetes

Investigational drug may hold benefit for patients with lung and ovarian cancers

Prenatal exposure to air pollutants is linked with growth delays

Air pollution, dementia, and cardiovascular disease

A new, potential treatment for nonalcoholic steatohepatitis with fibrosis

Role of ACE/ARB inhibitors in the treatment of COVID-19

Do ACE inhibitors increase SARS-CoV-2 binding to ACE2?

Smoking doubles risk of severe COVID-19 disease

Toxic cell atlas can guide discovery of new drugs for neurodegeneration

Short-term exposure to even low levels of air pollution can affect gene expression

DsbA-L gene may play a role in protecting respiratory function of the elderly

Study unravels antibacterial effects of nanopillars in insect wings

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