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Researchers reveal pathways that lead to the development of tissue-resident lymphocytes

Researchers from the University of Science and Technology of China) of the Chinese Academy of Science (CAS), teamed up with scientists from Aix Marseille University, discovered that hematopoietic progenitors possessed the differentiation potential to type 1 innate lymphoid cells in adult liver, and dissected the regulation mechanisms of such cell differentiation, revealing the pathways that lead to the development of tissue-resident lymphocytes.

31 Mar 2021

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

The ongoing COVID-19 pandemic, caused by SARS-CoV-2, is now established to be more likely to lead to symptomatic and serious illness in males relative to females. This may extend as far back as pregnancy, suggests a recent study.

31 Mar 2021

SARS-CoV-2 inhibits the cellular response to interferon

Researchers have explored the effect of SARS-CoV-2 infection on the function of RIG-I and MDA5, and ultimately on interferon production.

31 Mar 2021

Microbiota-derived molecules do not change the entry or replication of SARS-CoV-2 in intestinal cells

A study conducted at the University of Campinas in the state of São Paulo, Brazil, shows that compounds produced by gut microbiota (bacteria and other microorganisms) during fermentation of insoluble fiber from dietary plant matter do not affect the ability of the novel coronavirus SARS-CoV-2 to enter and replicate in cells lining the intestines.

30 Mar 2021

Rare genetic variant may explain severe COVID-19 in young healthy male patients

A recent study describes the association of rare alleles in a specific gene with severe COVID-19 in young male patients.

29 Mar 2021

GBP5 protein may play a key role in suppressing inflammation in rheumatoid arthritis

New research led by scientists at Washington State University has found that a protein known as GBP5 appears to play a key role in suppressing inflammation in rheumatoid arthritis, a potentially debilitating disease in which the immune system mistakenly attacks the body's own joint tissues.

29 Mar 2021

Scientists seek Covid treatment answers in cheap, older drugs

Could a decades-old antidepressant be a secret weapon against covid? A few scientists think so, after two small studies showed that fluvoxamine, typically prescribed for obsessive-compulsive disorder, prevented serious illness in all participants who took the pills soon after developing symptoms.

29 Mar 2021

Selecting SARS-CoV-2 inhibitors in human airway epithelial cells

In a recent article currently available on the bioRxiv* preprint server, researchers from Belgium and the U.S. demonstrated a robust replication model for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolates in primary human epithelial cells at the air-liquid interface and appraised the antiviral effect of selected viral replication inhibitors.

28 Mar 2021

DNMT3a plays a key role in regulating HSC responses to infections

Humans are born with tens of thousands of hematopoietic stem cells (HSCs) that collectively ensure lifelong production of blood and immune cells that protect us from infections.

26 Mar 2021

UCLA researchers receive NIH grants to identify new ways to treat pancreatic cancer

A team of researchers from the UCLA Jonsson Comprehensive Cancer Center has been awarded two research grants totaling $6 million from the National Institutes of Health to identify new ways to treat pancreatic cancer.

25 Mar 2021

Dual-antigen COVID-19 vaccine elicits humoral and cellular immune responses in mice

The scientific consensus is that safe and highly effective vaccines are required to end the ongoing pandemic of coronavirus disease 2019 COVID-19, caused by SARS-CoV-2. A new study describes a new vaccine that presents two viral antigens to the human immune system, in order to elicit a more efficacious response.

25 Mar 2021

Could an mRNA vaccine second dose reduce cellular immunity in previously infected individuals?

A new study, which was released on the bioRxiv* preprint server, shows the differential effect that a standard vaccine protocol may have on individuals, based on their history of prior infection with the virus.

25 Mar 2021

Researchers examine SARS-CoV-2 RNA interactome

A new study focuses on the identification of RNA-binding protein by mass spectrometry (ChIRP-M/S) approach. This study develops a global map that contains the complete set of host proteins that involve the SARS-CoV-2 genome during infection. This study has successfully identified new SARS-CoV-2 host dependency factors by merging proteomics data with gene silencing experiments. Such a discovery has paved new roads to develop more antiviral therapies.

25 Mar 2021

Researchers examine acriflavine's antiviral potential against SARS-CoV-2

Acriflavine is traditionally employed as a topical antiseptic, though has more recently been implicated as an antiviral agent at low doses, potentially by stimulating the production of interferon. In a new study recently uploaded to the bioRxiv* preprint server, the application of the drug to SARS-CoV-2 infection is investigated, demonstrating a broad activity towards a range of other betacoronaviruses.

24 Mar 2021

SARS-CoV-2 can cause persistent dendritic cell deficiencies

In a new study, the persistent influence of SARS-CoV-2 on dendritic cell deficiency seven months post-infection is asserted, and the mechanism of action investigated.

24 Mar 2021

Changes in OASI gene expression increases risk of Alzheimer's and severe COVID-19 infection

Previous research identified the interferon-responsive OAS1 gene as a risk gene for Alzheimer's disease. OAS1 is an enzyme that binds to double-stranded RNA and induces the conformation to create oligoadenylates. They also activate RNase L to break down RNA.

23 Mar 2021

Research identifies ways to prevent coronavirus spread to the nervous system

A number of studies have shown that human coronaviruses, including SARS-CoV-2 which causes COVID-19, appear to attack neurons and the nervous system in vulnerable populations.

23 Mar 2021

Study reveals a genetic variant linked to COVID-19 severity in young men

A study of young men with COVID-19 has revealed a genetic variant linked to disease severity.

23 Mar 2021

SARS-CoV-2 variants develop resistance against type I interferons

A study conducted at the University of Colorado and National Institutes of Health, USA, has revealed that the resistance developed by newly emerging variants of SARS-CoV-2 against host interferon responses could serve as a potential driving force for viral evolution.

22 Mar 2021

Clofazimine inhibits coronaviruses including SARS-CoV-2, study finds

Researchers at the University of Hong Kong found that Clofazimine, a lipophilic antimicrobial riminophenazine dye used in combination with agents like rifampicin and dapsone to treat leprosy, inhibits coronaviruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19 disease.

21 Mar 2021

Interferon News and Research

Researchers reveal pathways that lead to the development of tissue-resident lymphocytes

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

SARS-CoV-2 inhibits the cellular response to interferon

Microbiota-derived molecules do not change the entry or replication of SARS-CoV-2 in intestinal cells

Rare genetic variant may explain severe COVID-19 in young healthy male patients

GBP5 protein may play a key role in suppressing inflammation in rheumatoid arthritis

Scientists seek Covid treatment answers in cheap, older drugs

Selecting SARS-CoV-2 inhibitors in human airway epithelial cells

DNMT3a plays a key role in regulating HSC responses to infections

UCLA researchers receive NIH grants to identify new ways to treat pancreatic cancer

Dual-antigen COVID-19 vaccine elicits humoral and cellular immune responses in mice

Could an mRNA vaccine second dose reduce cellular immunity in previously infected individuals?

Researchers examine SARS-CoV-2 RNA interactome

Researchers examine acriflavine's antiviral potential against SARS-CoV-2

SARS-CoV-2 can cause persistent dendritic cell deficiencies

Changes in OASI gene expression increases risk of Alzheimer's and severe COVID-19 infection

Research identifies ways to prevent coronavirus spread to the nervous system

Study reveals a genetic variant linked to COVID-19 severity in young men

SARS-CoV-2 variants develop resistance against type I interferons

Clofazimine inhibits coronaviruses including SARS-CoV-2, study finds

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