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Discovery provides critical clues to why many immunotherapies trigger dangerous side effects

It's not often that a failed clinical trial leads to a scientific breakthrough. When patients in the UK started showing adverse side effects during a cancer immunotherapy trial, researchers at La Jolla Institute for Immunology (LJI) Center for Cancer Immunotherapy and University of Liverpool went back through the data and worked with patient samples to see what went wrong.

5 May 2022

Study identifies a protein in Mycobacterium tuberculosis that contributes to drug tolerance

Weill Cornell Medicine researchers have identified a protein in Mycobacterium tuberculosis (Mtb) that contributes to drug tolerance, a phenomenon that allows bacteria to survive treatment with drugs that would normally kill them.

4 May 2022

SARS-CoV-2 BA.2 poses greater risk to global health than BA.1

In a recent study published in the journal Cell, researchers investigated distinguishing virological characteristics of Omicron sub-variant BA.2.

3 May 2022

Understanding dysphagia symptoms after spine surgery can help improve patients' quality of life

Difficulty swallowing is one of the most common complications of anterior cervical spine surgery (ACSS).

3 May 2022

Lung cancer risk increases with emphysema severity, study reveals

CT-detected emphysema is linked to a higher risk of lung cancer, a risk that increases with emphysema severity, according to a new study published in the journal Radiology.

3 May 2022

Precision cut slice lung model to study early host viral pathogenesis of SARS-CoV-2 infection

Researchers applied their previously developed precision-cut lung slice model to study the initial events in SARS-CoV-2 pathogenicity in humans.

3 May 2022

Studying immunomodulatory effects of microbiota helps design prophylactic and therapeutic interventions against COVID-19

Researchers reviewed the potential clinically relevant mechanisms by which microbiota and microbiota-derived metabolites influence the host immune responses to SARS-CoV-2 infection.

3 May 2022

Needle- and adjuvant-free vaccination with non-infectious T4-COVID nanoparticles induces strong immunity in mice

Researchers developed a mucosal vaccine for COVID-19 based on bacteriophage.

3 May 2022

Features of SARS-CoV-2 Omicron BA.2 sublineage spike protein

Researchers assessed the traits of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.2 sublineage spike (S) protein.

3 May 2022

Study uncovers blood clotting and immune protein pathways impacted in children with severe COVID-19

Researchers have discovered the blood clotting and immune protein pathways that are activated in severe cases of COVID-19 in children, paving the way for earlier diagnosis and more targeted treatments.

3 May 2022

The generation of SARS-CoV-2 virus-like particles in insect cells

Researchers have reported the development of a promising COVID-19 vaccine candidate which is based on SARS-CoV-2 VLPs, derived from the co-expression of the spike, membrane, and envelope structural proteins in the baculovirus expression system.

2 May 2022

New cardiac defibrillator implanted under the skin greatly reduces patient complications

High-risk patients who need defibrillators to prevent cardiac arrest can experience fewer complications with a type of device implanted under the skin, a Canadian study has found.

30 Apr 2022

Uncovering a new molecule that shows potential as antidote for carbon monoxide poisoning

Carbon monoxide is an odorless and colorless gas made when fossil fuels burn incompletely. It's also a silent killer.

29 Apr 2022

Study reports an orally available SARS-CoV-2 Mpro inhibitor with potent in vivo antiviral activity

Researchers examined the efficiency of the main protease (Mpro) inhibitor against SARS-CoV-2.

29 Apr 2022

Yale researchers identify immune system culprit in severe COVID cases

Yale researchers have identified a particular immune response pathway that leads to severe illness and death in people infected by the SARS-CoV-2 virus.

28 Apr 2022

Study investigates intestinal ischemia in COVID-19 patients

A team of Italian scientists has presented case reports of five coronavirus disease 2019 (COVID-19) patients undergoing emergency surgery for intestinal ischemia.

28 Apr 2022

Identification of a SARS-CoV-2 neutralizing human monoclonal antibody with a remarkable broad-spectrum neutralization and protection efficacy

Researchers identified a human monoclonal antibody (mAb), 87G7, with in vitro neutralizing activity against several SARS-CoV-2 VOCs, including Alpha, Beta, Gamma, Delta, and Omicron.

28 Apr 2022

Lungs News and Research

Discovery provides critical clues to why many immunotherapies trigger dangerous side effects

Study identifies a protein in Mycobacterium tuberculosis that contributes to drug tolerance

SARS-CoV-2 BA.2 poses greater risk to global health than BA.1

Understanding dysphagia symptoms after spine surgery can help improve patients' quality of life

Lung cancer risk increases with emphysema severity, study reveals

Precision cut slice lung model to study early host viral pathogenesis of SARS-CoV-2 infection

Studying immunomodulatory effects of microbiota helps design prophylactic and therapeutic interventions against COVID-19

Needle- and adjuvant-free vaccination with non-infectious T4-COVID nanoparticles induces strong immunity in mice

Features of SARS-CoV-2 Omicron BA.2 sublineage spike protein

Study uncovers blood clotting and immune protein pathways impacted in children with severe COVID-19

The generation of SARS-CoV-2 virus-like particles in insect cells

New cardiac defibrillator implanted under the skin greatly reduces patient complications

Uncovering a new molecule that shows potential as antidote for carbon monoxide poisoning

Study reports an orally available SARS-CoV-2 Mpro inhibitor with potent in vivo antiviral activity

Yale researchers identify immune system culprit in severe COVID cases

Study investigates intestinal ischemia in COVID-19 patients

Identification of a SARS-CoV-2 neutralizing human monoclonal antibody with a remarkable broad-spectrum neutralization and protection efficacy

New insight into the body’s response to tuberculosis may help design a more effective vaccine

mRNA booster vaccination found to protect aged mice against the Omicron variant of SARS-CoV-2

Researchers use mouse model to explore correlation of impaired interferon-mediated immune response with severe COVID-19

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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