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Study shows how neighborhood-level social vulnerability impacts COVID-19 hospitalization outcomes

COVID-19 has sent nearly 900,000 Americans to the hospital in the past two years. A new study shows that the ZIP codes they came from had a lot to do with how sick they were when they got to the hospital, and how much care they needed once they were there.

21 Feb 2022

Generic version of Viagra could be the long-waited remedy for dogs with megaesophagus

Sildenafil, the generic version of the drug known as Viagra, could be the long-waited remedy for a group of dogs with a rare disorder called megaesophagus.

21 Feb 2022

Study suggests non-classical inhibition of TBK1/IKKε is protective against severe COVID-19 immunopathology in vivo

A study posted suggested the inhibition of TBK1 and its homolog KKε could decrease the severity of COVID-19.

21 Feb 2022

Biochemical changes in lung physiology not responsible for severe clinical outcomes in the older population

Researchers investigated whether age-dependent changes in lung physiology make the elderly disproportionately susceptible to SARS-CoV-2 infection.

21 Feb 2022

Early antiretroviral therapy is crucial to fight against HIV and latent tuberculosis

Two weeks makes a big difference in treating the animal version of HIV and latent tuberculosis, researchers from Texas Biomedical Research Institute, Southwest National Primate Research Center and colleagues report this month in the Journal of Clinical Investigation.

18 Feb 2022

Study reports a highly attenuated SARS-CoV-2 that could serve as a live-attenuated vaccine platform

The research showed a highly attenuated SARS-CoV-2 strain that might be used as a live-attenuated vaccine platform and a BSL-2 experimental system.

18 Feb 2022

Study shows mink can be infected by Omicron and efficiently transmit the virus to other mink

Researchers have been examining the pathology and spread of the Omicron variant in mink.

18 Feb 2022

Study finds antigenic profile of Omicron RBD is distinct from the prior SARS-CoV-2 variants of concern

A new study aimed to clarify whether extensive RBD mutations could affect the magnitude and immunodominance hierarchy of the host antibody response.

18 Feb 2022

Intermediate size nanoparticles may be effective at stopping internal bleeding

Traumatic injuries are the leading cause of death in the U.S. among people 45 and under, and such injuries account for more than 3 million deaths per year worldwide.

17 Feb 2022

Dual access veno-arterial approach increases mortality rate for babies in respiratory failure put on ECMO

The current trend of using two cannulas to place most newborns in respiratory failure on life-sustaining ECMO, one in the right internal jugular vein and a second in the right common carotid artery, rather than a single cannula in the right internal jugular, increases mortality rates for these babies, investigators report.

17 Feb 2022

Ensitrelvir, a novel SARS-CoV-2 antiviral

S-217622 reduces the viral load and help alleviate the severity of SARS-CoV-2 in infected hamsters.

17 Feb 2022

Gut enzymes open a gateway to create universal blood-type donor organs

A study published in Science Translational Medicine performed at the Latner Thoracic Surgery Research Laboratories and UHN's Ajmera Transplant Centre has proved that it is possible to convert blood type safely in donor organs intended for transplantation.

16 Feb 2022

Respiratory virus particles likely travel greater distance than previously thought

A modeling study raises questions about how far respiratory droplets, like those that transmit the virus that causes COVID-19, can travel before becoming harmless.

16 Feb 2022

Incomplete repair of the damaged lung may contribute to death from COVID-19 and non-COVID ARDS

Investigators studying lung cells have discovered that the normal repair process that occurs after lung disease or injury appears to be incomplete but still ongoing in patients who died of COVID-19 and non-COVID acute respiratory distress syndrome (ARDS).

15 Feb 2022

Structural protein vimentin facilitates SARS-CoV-2 entry into endothelial cells

Researchers suggest that extracellular vimentin may act as a coreceptor to allow for SARS-CoV-2 entry into cells.

14 Feb 2022

Study identifies a link between mortality of newborns on ECMO and red blood cell transfusion volume

Newborns in respiratory failure who require the life-sustaining support of ECMO also require transfusion of red blood cells. But a new study indicates that the higher volume of these oxygen-carrying blood cells the babies receive, the higher their mortality rate.

14 Feb 2022

Hundreds of new proteins that could play a role in cystic fibrosis discovered

Researchers at the University of Toronto have identified hundreds of new proteins that could play a role in cystic fibrosis, and which may shed light on why some patients respond better than others to current therapies.

14 Feb 2022

Study describes a β-CoV spike protein target for protective antibodies that may facilitate pan-β-CoV vaccine development

In a recent study published in Science Translational Medicine, researchers characterized a human antibody targeting betacoronaviruses (β-CoVs).

14 Feb 2022

mRNA-1273 and mRNA-1273.529 Omicron-specific boosters highly effective in mouse model

In a study posted to the bioRxiv* preprint server, a team of researchers from the United States evaluated the protective effect of the preclinical version of the current Moderna Omicron-targeted mRNA-1273.529 vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 Omicron infection in mice.

14 Feb 2022

Nitazoxanide shows promise for COVID-19 treatment in animal model

In a recent study posted to the bioRxiv* pre-print server, researchers demonstrated that Nitazoxanide (NTZ), an oral drug, broadly inhibits replication of several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in preclinical models of infection.

13 Feb 2022

Lungs News and Research

Study shows how neighborhood-level social vulnerability impacts COVID-19 hospitalization outcomes

Generic version of Viagra could be the long-waited remedy for dogs with megaesophagus

Study suggests non-classical inhibition of TBK1/IKKε is protective against severe COVID-19 immunopathology in vivo

Biochemical changes in lung physiology not responsible for severe clinical outcomes in the older population

Early antiretroviral therapy is crucial to fight against HIV and latent tuberculosis

Study reports a highly attenuated SARS-CoV-2 that could serve as a live-attenuated vaccine platform

Study shows mink can be infected by Omicron and efficiently transmit the virus to other mink

Study finds antigenic profile of Omicron RBD is distinct from the prior SARS-CoV-2 variants of concern

Intermediate size nanoparticles may be effective at stopping internal bleeding

Dual access veno-arterial approach increases mortality rate for babies in respiratory failure put on ECMO

Ensitrelvir, a novel SARS-CoV-2 antiviral

Gut enzymes open a gateway to create universal blood-type donor organs

Respiratory virus particles likely travel greater distance than previously thought

Incomplete repair of the damaged lung may contribute to death from COVID-19 and non-COVID ARDS

Structural protein vimentin facilitates SARS-CoV-2 entry into endothelial cells

Study identifies a link between mortality of newborns on ECMO and red blood cell transfusion volume

Hundreds of new proteins that could play a role in cystic fibrosis discovered

Study describes a β-CoV spike protein target for protective antibodies that may facilitate pan-β-CoV vaccine development

mRNA-1273 and mRNA-1273.529 Omicron-specific boosters highly effective in mouse model

Nitazoxanide shows promise for COVID-19 treatment in animal model

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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