Receptor News and Research

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Short-term stress impairs brain-cell communication

Short-term stress lasting as little as a few hours can impair brain-cell communication in areas associated with learning and memory, University of California, Irvine researchers have found.

12 Mar 2008

Turning off rogue macrophages

University of Pennsylvania scientists studying macrophages, the biological cells that spring from white blood cells to eat and destroy foreign or dying cells, have discovered how these "policemen" differentiate between friend and foe.

12 Mar 2008

Researchers find treatment for familial cold autoinflammatory syndrome

Dalhousie Medical School dermatologist Dr. Barrie Ross and his colleagues have successfully ended a 20-year quest to find a treatment for Familial Cold Autoinflammatory Syndrome (FCAS).

12 Mar 2008

New diagnostic tool detects and monitors bladder cancer

Medical University of South Carolina (MUSC) Foundation for Research and Development announced a promising new diagnostic tool to detect and monitor bladder cancer.

12 Mar 2008

Study aims to improve treatment for children born with heart defects

Trying to understand and stop the collateral lung damage that can occur in babies with congenital heart disease is the focus of a new study.

11 Mar 2008

Late treatment with letrozole (Femara) can reduce breast cancer recurrence risk

Treatment with the aromatase inhibitor letrozole (Femara) can reduce the risk of breast cancer recurrence even when initiated one to seven years after a course of tamoxifen therapy.

11 Mar 2008

Femara helps protect against return of breast cancer after completing Tamoxifen therapy

Women may reduce the risk of their breast cancer returning by starting treatment with Femara (letrozole tablets) anywhere from one to seven years after finishing tamoxifen therapy, according to a new analysis published in the Journal of Clinical Oncology.

11 Mar 2008

Cardiac effects associated with breast cancer treatment appear lower with dose-dense chemotherapy

A new pilot study by investigators at Memorial Sloan-Kettering Cancer Center (MSKCC) found that breast cancer patients can be treated safely with a "dose-dense" regimen of standard chemotherapy agents and the antibody trastuzumab (Herceptin), a drug that has previously been shown to cause cardiac toxicity.

11 Mar 2008

Cardiac effects associated with breast cancer treatment appear lower

A new pilot study by investigators at Memorial Sloan-Kettering Cancer Center (MSKCC) found that breast cancer patients can be treated safely with a “dose-dense” regimen of standard chemotherapy agents and the antibody trastuzumab (Herceptin®), a drug that has previously been shown to cause cardiac toxicity.

10 Mar 2008

Researchers discover molecular pathway in blood vessels that controls blood pressure and vascular function

University of Iowa researchers have identified a molecular pathway in blood vessels that controls blood pressure and vascular function and may help explain why certain drugs for type II diabetes also appear to lower patients' blood pressure.

6 Mar 2008

New potential drug target for atherosclerosis

A nuclear receptor protein, known for controlling the ability of cells to burn fat, also exerts powerful anti-inflammatory effects in arteries, suppressing atherosclerosis in mice prone to developing the harmful plaques, according to new research by scientists at the Salk Institute for Biological Studies and the Harvard School of Public Health.

6 Mar 2008

Genetic mutations involved in IGF-I signaling pathway influence life span

Mutations in genes governing an important cell-signaling pathway influence human longevity, scientists at the Albert Einstein College of Medicine of Yeshiva University have found.

6 Mar 2008

Rimonabant weight-loss drug might fight alcoholic fatty liver

The cannabinoid receptors best known for delivering the psychological effects of marijuana also explain the connection between chronic alcohol use and a buildup of fat in the liver, according to a report in the March issue of Cell Metabolism, a publication of Cell Press.

6 Mar 2008

Cell proteins could offer a future drug target against weight gain

Two cell proteins that relax the gut and help accommodate a big meal have been identified by UCL (University College London) scientists.

4 Mar 2008

FDA approves Aloxi injection for prevention of postoperative nausea and vomiting

Eisai Corporation of North America, its U.S. subsidiary, MGI PHARMA, INC., and Helsinn Healthcare SA today announced that the U.S. Food and Drug Administration (FDA) has approved Aloxi (palonosetron hydrochloride) injection for the prevention of postoperative nausea and vomiting (PONV) for up to 24 hours following surgery.

4 Mar 2008

Estradiol hormone protects against hearing loss

The "female sex hormone" estradiol is present in both men and women, and is generated from testosterone in men by the protein aromatase.

4 Mar 2008

Ten years down the line a pill to cure obesity

British scientists say they may have found a new way to treat obesity by stopping the stomach from expanding.

4 Mar 2008

Preclinical antitumor efficacy evaluation of dendrimer-based methotrexate conjugates

Although a variety of nanoparticles continue to show promise for improving cancer imaging and therapy, regulators and drug developers are concerned that these delivery systems may prove difficult to manufacture on a consistent basis, which is key for any agent designed for use in humans.

3 Mar 2008

Fluorescent nanoparticles image tumor marker in animals

Since 2004 the U.S. Food and Drug Administration has approved three new-generation anticancer therapies that target epidermal growth factor receptor (EGFR), a protein that is greatly overexpressed on certain types of tumors, including some forms of colorectal and lung cancer.

3 Mar 2008

Ciliary neurotrophic factor protects nerve cells

Since its discovery as a protein that gets specifically released in response to brain injury, ciliary neurotrophic factor (CNTF) has prompted much interest as a potential therapeutic agent.

1 Mar 2008