Biochemistry

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New chemical probe can selectively inhibit human COQ8A protein in cells

Inhibition of the COQ8 protein could be beneficial in the treatment of diseases such as cancer. COQ8 is needed for the biosynthesis of coenzyme Q, also known as ubiquinone.

28 Nov 2022

Astrocytes in the brains of epileptic mice exhibit an acid response with intensified seizures

Researchers at Tohoku University have shown that astrocytes in the mouse brain exhibit an acid response with intensified epileptic seizures.

25 Nov 2022

Pocket feature in SARS-CoV-2 spike protein is present in all deadly coronaviruses, study reveals

Scientists have discovered why some coronaviruses are more likely to cause severe disease, which has remained a mystery, until now.

24 Nov 2022

A simple method to prepare carbon isotope-labeled versions of drugs and diagnostics

Dr. Benjamin Rotstein and collaborators unveil an operationally simple method to prepare carbon isotope-labeled versions of drugs and diagnostics.

22 Nov 2022

Experts investigate the role of IL-26 in COVID-19

Researchers at Karolinska Institutet in Sweden have shown that patients with acute COVID-19 infection have increased levels of the cytokine IL-26 in their blood. Moreover, high IL-26 levels correlate with an exaggerated inflammatory response that signifies severe cases of the disease. The findings, which are presented in Frontiers in Immunology, indicate that IL-26 is a potential biomarker for severe COVID-19.

17 Nov 2022

Newly identified pathway transforms biologically inert peptide into structurally complex antibiotics

Researchers in the Princeton University Department of Chemistry have discovered a new multi-step pathway through which bacteria found in the mammalian gut produce antimicrobial peptides.

14 Nov 2022

Novel drug could help to fight both COVID-19 and cancer

While vaccination can provide life-saving protection against COVID-19, scientists are still searching for ways to treat severe infections, including in people who cannot get vaccinated or in the event that dangerous new strains of the virus arise that could bypass vaccine protection.

14 Nov 2022

Virginia Tech researcher receives $400,000 NSF grant to develop novel skin scent sampler

Human skin is the body's largest organ. It also protects internal living tissue and other organs, regulates body temperature, and even metabolizes vitamin D.

13 Nov 2022

Researchers discover new antiviral compounds derived from two Korean native plants

Codonopsis lanceolata, more commonly referred to as "deodeok", is used as a medicinal herb in South Korea.

11 Nov 2022

UCR scientists pave the way for diabetes and cancer patients to forget injections

Researchers at UC Riverside are paving the way for diabetes and cancer patients to forget needles and injections, and instead take pills to manage their conditions.

10 Nov 2022

Copper and copper-binding proteins could be potential targets for cancer treatment

For cancer cells to grow and spread around the human body, they need proteins that bind copper ions. New research about how cancer-related proteins bind the metal and how they interact with other proteins, opens up potential new drug targets in the fight against cancer.

10 Nov 2022

MicroRNAs can upregulate proteins in addition to downregulating protein production

microRNAs can play a role in cancer development and are thought to exclusively suppress protein expression in dividing cells, such as tumor cells.

10 Nov 2022

Novel branched ionizable lipid greatly increases the efficiency of mRNA delivery

Messenger RNA (mRNA) are biological molecules that transfer the information coded by genes in the nucleus to the cytoplasm for protein synthesis by ribosomes.

10 Nov 2022

Researchers use lasso-grafting for designing receptor agonists with enhanced pharmacokinetics

Cell growth and repair are stimulated by biomolecules known as cytokines and growth factors. Unfortunately, delivering adequate concentrations of these molecules to the brain for treating neurological conditions like Alzheimer's disease is challenging as they are either cleared out of the blood very quickly or do not penetrate neural tissue effectively.

8 Nov 2022

Beer hop compounds could serve as the basis for nutraceuticals to combat Alzheimer’s disease

Beer is one of the oldest and most popular beverages in the world, with some people loving and others hating the distinct, bitter taste of the hops used to flavor its many varieties.

7 Nov 2022

Beckman Coulter Life Sciences and Pillar Biosciences Sign Application Development Agreement for the Biomek NGeniuS System

More companies around the world continue turning to Beckman Coulter Life Sciences, a global leader in laboratory automation and innovation, for their next generation sequencing (NGS) needs with the Biomek NGeniuS System.

From Beckman Coulter Life Sciences 4 Nov 2022

Anti-herpes drug can fight against antibiotic-resistant bacterium

A UNIGE team reveals that a drug used against herpes can fight a bacterium that is resistant to most antibiotics by weakening its defense mechanisms.

4 Nov 2022

Scientists uncover a key property needed for CELMoD drugs to be effective

Scientists at Scripps Research have uncovered a critical feature that a promising new class of cancer drugs, known as CELMoDs, needs to be effective.

3 Nov 2022

Researchers provide insights on how to overcome resistance in cancer therapy

The latest developmental drugs, particularly for the use in oncology, rely on the targeted degradation of harmful pathogenic proteins.

3 Nov 2022

New test detects low levels of pathogenic amphiphilic endotoxins

Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a fast and cost-effective method to test liquids for a ubiquitous family of chemical compounds known as amphiphiles, which are used to detect diseases such as early-stage tuberculosis and cancer as well as to detect toxins in drugs, food, medical devices and water supplies.

3 Nov 2022

Biochemistry

New chemical probe can selectively inhibit human COQ8A protein in cells

Astrocytes in the brains of epileptic mice exhibit an acid response with intensified seizures

Pocket feature in SARS-CoV-2 spike protein is present in all deadly coronaviruses, study reveals

A simple method to prepare carbon isotope-labeled versions of drugs and diagnostics

Experts investigate the role of IL-26 in COVID-19

Newly identified pathway transforms biologically inert peptide into structurally complex antibiotics

Novel drug could help to fight both COVID-19 and cancer

Virginia Tech researcher receives $400,000 NSF grant to develop novel skin scent sampler

Researchers discover new antiviral compounds derived from two Korean native plants

UCR scientists pave the way for diabetes and cancer patients to forget injections

Copper and copper-binding proteins could be potential targets for cancer treatment

MicroRNAs can upregulate proteins in addition to downregulating protein production

Novel branched ionizable lipid greatly increases the efficiency of mRNA delivery

Researchers use lasso-grafting for designing receptor agonists with enhanced pharmacokinetics

Beer hop compounds could serve as the basis for nutraceuticals to combat Alzheimer’s disease

Beckman Coulter Life Sciences and Pillar Biosciences Sign Application Development Agreement for the Biomek NGeniuS System

Anti-herpes drug can fight against antibiotic-resistant bacterium

Scientists uncover a key property needed for CELMoD drugs to be effective

Researchers provide insights on how to overcome resistance in cancer therapy

New test detects low levels of pathogenic amphiphilic endotoxins

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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