Cell Biology

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A dimensional reduction strategy for enhanced cryopreservation of red blood cells

Small amounts of nanometer-thin metal-organic layers efficiently protect red blood cells during freezing and thawing, as a team of researchers writing in the journal Angewandte Chemie has discovered. The nanolayers, made from metal-organic frameworks based on the metal hafnium, prevent ice crystal formation at very low concentrations. This effective novel cryoprotection mode could be used to develop new and more efficient cryoprotectants for the biosciences.

29 Apr 2023

Imbalanced electrical charges in biomolecular condensates spark redox reactions

The human body relies heavily on electrical charges. Lightning-like pulses of energy fly through the brain and nerves and most biological processes depend on electrical ions traveling across the membranes of each cell in our body.

28 Apr 2023

New approach for efficient engineering of cell and gene therapies

A new approach to the genetic engineering of cells promises significant improvements in speed, efficiency, and reduction in cellular toxicity compared to current methods.

28 Apr 2023

Researchers develop novel bio-inspired molecules to enhance bone regeneration

People's ability to regenerate bones declines with age and is further decreased by diseases such as osteoporosis.

28 Apr 2023

How inert, sleeping bacteria spring back to life

Solving a riddle that has confounded biologists since bacterial spores - inert, sleeping bacteria - were first described more than 150 years ago, researchers at Harvard Medical School have discovered a new kind of cellular sensor that allows spores to detect the presence of nutrients in their environment and quickly spring back to life.

27 Apr 2023

Study reveals the mechanism behind oligomeric assembly of a BAR-domain-containing protein

Cell membranes play a critical role by serving as containment units and separating the inner cellular space from the extracellular environment.

26 Apr 2023

Researchers investigate the roles of STAT3α and STAT3β isoforms in aggressive breast cancer

A new research paper was published in Oncotarget's Volume 14 on April 24, 2023, entitled, "Differential silencing of STAT3 isoforms leads to changes in STAT3 activation."

26 Apr 2023

Research uncovers antibodies that are still effective against new variants of SARS-CoV-2

An anonymous San Diego resident has become a fascinating example of how the human immune system fights SARS-CoV-2.

26 Apr 2023

Researchers unravel processes that direct the development of astrocyte structure

Researchers at Baylor College of Medicine have unraveled the processes that give astrocytes, the most abundant glial cell in the brain, their special bushy shape, which is fundamental for brain function.

26 Apr 2023

Study sheds light on the mechanisms behind circadian rhythms

New research from a multidisciplinary team helps to illuminate the mechanisms behind circadian rhythms, offering new hope for dealing with jet lag, insomnia and other sleep disorders.

26 Apr 2023

Study reveals ERK signaling as a crucial molecular switch between scarring and regeneration

Why do some animals regenerate lost tissues after injury while others don't? Researchers from the lab of Kerstin Bartscherer (Osnabrück University and formerly Hubrecht Institute) and Ashley Seifert (University of Kentucky) studied spiny mice, which have a remarkable regenerative capacity, to answer this question.

26 Apr 2023

Discovery of Helicobacter's Achilles heel offers great potential for the development of new drugs

LMU researchers have discovered a weakness in the bacterium Helicobacter pylori, which could be exploited to develop new drugs.

26 Apr 2023

Previously unknown mechanisms may lead to new approaches to fight viral infections

Viruses like influenza A and Ebola invade human cells in a number of steps. In an interdisciplinary approach, research teams from Heidelberg University and Heidelberg University Hospital investigated the final stages of viral penetration using electron tomography and computer simulations.

25 Apr 2023

Highly activatable Raman probes detect multiple enzyme activities in heterogeneous biological tissues

Raman imaging offers a greater potential for detecting multiple enzyme activities than fluorescence imaging, demonstrate Tokyo Tech researchers by developing 9CN-rhodol-based activatable Raman probes using a novel mechanism for Raman signal activation.

25 Apr 2023

T cell-mediated recognition of conserved bacterial epitope generates broad immunity

Typically T cells of the immune system respond to a specific feature (antigen) of a microbe, thereby generating protective immunity.

25 Apr 2023

A new platform for testing cancer drug toxicity

For people with cancer, chemotherapy saves lives, but for some patients, the treatment comes with a side effect—heart damage.

25 Apr 2023

Study establishes a new method for examining relationships between neuron type and function

Investigators at Cedars-Sinai have created computer-generated models to bridge the gap between "test tube" data about neurons and the function of those cells in the living brain.

25 Apr 2023

The Wonder of DNA: Reflections from Dr. Francis Collins on the 20th Anniversary of the Human Genome Project

To highlight how far the field of genetics has come, we spoke with Dr. Francis Collins, the leader of the Human Genome Project about his incredible career in genetics.

25 Apr 2023

Exploring metabolic compatibility as a possible limiting factor to prokayrotic endosymbioses

"One of the great mysteries of biology," says Eric Libby, former SFI Postdoctoral Fellow, now an associate professor at the Integrated Science Lab (IceLab), Umeå University in Sweden, "is eukaryogenesis, or how eukaryotes arose." Scientists consider this to be a period of major evolutionary transition, critical to our understanding of the history and evolution of life on Earth.

24 Apr 2023

New computational method identifies routes of cellular differentiation in acute myeloid leukemia

Researchers have developed a new method to distinguish between cancerous and healthy stem cells and progenitor cells from samples of patients with acute myeloid leukemia (AML), a disease driven by malignant blood stem cells that have historically been difficult to identify.

24 Apr 2023

Cell Biology

A dimensional reduction strategy for enhanced cryopreservation of red blood cells

Imbalanced electrical charges in biomolecular condensates spark redox reactions

New approach for efficient engineering of cell and gene therapies

Researchers develop novel bio-inspired molecules to enhance bone regeneration

How inert, sleeping bacteria spring back to life

Study reveals the mechanism behind oligomeric assembly of a BAR-domain-containing protein

Researchers investigate the roles of STAT3α and STAT3β isoforms in aggressive breast cancer

Research uncovers antibodies that are still effective against new variants of SARS-CoV-2

Researchers unravel processes that direct the development of astrocyte structure

Study sheds light on the mechanisms behind circadian rhythms

Study reveals ERK signaling as a crucial molecular switch between scarring and regeneration

Discovery of Helicobacter's Achilles heel offers great potential for the development of new drugs

Previously unknown mechanisms may lead to new approaches to fight viral infections

Highly activatable Raman probes detect multiple enzyme activities in heterogeneous biological tissues

T cell-mediated recognition of conserved bacterial epitope generates broad immunity

A new platform for testing cancer drug toxicity

Study establishes a new method for examining relationships between neuron type and function

The Wonder of DNA: Reflections from Dr. Francis Collins on the 20th Anniversary of the Human Genome Project

Exploring metabolic compatibility as a possible limiting factor to prokayrotic endosymbioses

New computational method identifies routes of cellular differentiation in acute myeloid leukemia

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