Genomics

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Scientists discover genetic variations that have a drastic impact on small molecules

The human organism requires a variety of small molecules, such as sugars or fats, in order to function properly.

14 Jan 2021

New deep-learning framework predicts gene regulation at single-cell level

Scientists at the University of California, Irvine have developed a new deep-learning framework that predicts gene regulation at the single-cell level.

13 Jan 2021

New genomics resource details the small RNA transcriptomes of four mosquito species

Researchers from Boston University School of Medicine provide a new genomics resource that details the small RNA transcriptomes (gene expression) of four bio-medically important mosquito species.

13 Jan 2021

Researchers identify link between ALS and accumulation of DNA-RNA hybrids in the genome

Researchers from the University of Seville and the University of Pavia have identified a link between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome.

13 Jan 2021

Large study provides new understanding of genome diversity in Ukrainian population

Today, the largest study of genetic diversity in Ukraine was published in the open science journal GigaScience.

13 Jan 2021

New taxonomic classification of non-skeletal rare congenital disorders with impact on bone physiology

Thanks to major progress in the understanding and management of rare congenital diseases and syndromes, many patients with these rare disorders are now living longer lives.

13 Jan 2021

Researchers identify a simple way to eliminate sequencing errors produced by portable DNA sequencer

Researchers have found a simple way to eliminate almost all sequencing errors produced by a widely used portable DNA sequencer, potentially enabling scientists working outside the lab to study and track microorganisms like the SARS-CoV-2 virus more efficiently.

13 Jan 2021

Daily circadian cycles may impact our ability to fight disease

An analysis of an exhaustive dataset on cells essential to the mammalian immune system shows that our ability to fight disease may rely more heavily on daily circadian cycles than previously assumed.

12 Jan 2021

Inherited or transmitted gut microbes affect skeletal development in animals

Gut microbes passed from female mice to their offspring, or shared between mice that live together, may influence the animals' bone mass, says a new study published today in eLife.

12 Jan 2021

Study monitors spatial shifts of liver gene expression in relationship to the circadian clock

Nothing in biology is static. Biological processes fluctuate over time, and if we are to put together an accurate picture of cells, tissues, organs etc., we have to take into account their temporal patterns. In fact, this effort has given rise to an entire field of study known as "chronobiology".

11 Jan 2021

Study sheds new light on the role of MLL4 gene in Kabuki syndrome

Scientists have known for years that mutations in the MLL4 gene can cause Kabuki syndrome, a rare developmental disorder.

11 Jan 2021

Master Regulator proteins control cancer transcriptional identity

Thousands of different genetic mutations have been implicated in cancer, but a new analysis of almost 10,000 patients found that regardless of the cancer's origin, tumors could be stratified in only 112 subtypes and that, within each subtype, the Master Regulator proteins that control the cancer's transcriptional state were virtually identical, independent of the specific genetic mutations of each patient.

11 Jan 2021

Researchers identify biomarkers in sperm for paternal offspring autism susceptibility

Biomarkers in human sperm have been identified that can indicate a propensity to father children with autism spectrum disorder.

11 Jan 2021

NIST compiles the first detailed tutorial on DNA origami

In a technique known as DNA origami, researchers fold long strands of DNA over and over again to construct a variety of tiny 3D structures, including miniature biosensors and drug-delivery containers.

8 Jan 2021

Using genomic analysis to map the introduction of SARS-CoV-2 virus in the UK

The SARS-CoV-2 virus was introduced to the United Kingdom well over 1,000 times in early 2020, according to researchers who analyzed more than 50,000 viral sequences from the first wave of the COVID-19 pandemic in the UK.

8 Jan 2021

Researchers develop new statistical method that generates significant genetic insights

Pleiotropy analysis, which provides insight on how individual genes result in multiple characteristics, has become increasingly valuable as medicine continues to lean into mining genetics to inform disease treatments. Privacy stipulations, though, make it difficult to perform comprehensive pleiotropy analysis because individual patient data often can't be easily and regularly shared between sites.

8 Jan 2021

Study shows how new antibiotic resistance genes arise from random DNA sequences

An important and still unanswered question is how new genes that cause antibiotic resistance arise. In a new study, Swedish and American researchers have shown how new genes that produce resistance can arise from completely random DNA sequences. The results have been published in the journal PLOS Genetics.

8 Jan 2021

Genetic blueprint provides insights into unique biology of egg-laying monotreme mammals

The genomes of egg-laying monotreme mammals, platypus and echidna, have been published in the prestigious journal Nature, providing a valuable public resource for research in mammalian biology and evolution, with applications for their conservation and health.

8 Jan 2021

Proteogenomics can help determine effective treatment for head and neck squamous cell carcinoma

Proteogenomic analysis may offer new insight into matching cancer patients with an effective therapy for their particular cancer.

7 Jan 2021

Researchers develop new sequencing-based approach for pathogen discovery

A sequencing-based solution can be utilized to determine infection clearance and microbiota recovery. Next, the researchers will apply the technique to investigate the coronavirus disease.

7 Jan 2021

Genomics

Scientists discover genetic variations that have a drastic impact on small molecules

New deep-learning framework predicts gene regulation at single-cell level

New genomics resource details the small RNA transcriptomes of four mosquito species

Researchers identify link between ALS and accumulation of DNA-RNA hybrids in the genome

Large study provides new understanding of genome diversity in Ukrainian population

New taxonomic classification of non-skeletal rare congenital disorders with impact on bone physiology

Researchers identify a simple way to eliminate sequencing errors produced by portable DNA sequencer

Daily circadian cycles may impact our ability to fight disease

Inherited or transmitted gut microbes affect skeletal development in animals

Study monitors spatial shifts of liver gene expression in relationship to the circadian clock

Study sheds new light on the role of MLL4 gene in Kabuki syndrome

Master Regulator proteins control cancer transcriptional identity

Researchers identify biomarkers in sperm for paternal offspring autism susceptibility

NIST compiles the first detailed tutorial on DNA origami

Using genomic analysis to map the introduction of SARS-CoV-2 virus in the UK

Researchers develop new statistical method that generates significant genetic insights

Study shows how new antibiotic resistance genes arise from random DNA sequences

Genetic blueprint provides insights into unique biology of egg-laying monotreme mammals

Proteogenomics can help determine effective treatment for head and neck squamous cell carcinoma

Researchers develop new sequencing-based approach for pathogen discovery

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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