Genomics

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Researchers examine the role of Shiga toxin in the immune system

E. coli food poisoning is one of the worst food poisonings, causing bloody diarrhea and kidney damage. But all the carnage might be just an unintended side effect, researchers from UConn Health report in the 27 November issue of Science Immunology.

7 Jan 2021

Researchers discover many genetic markers related to bone mineral accrual

A multidisciplinary team of researchers led by Children's Hospital of Philadelphia (CHOP) has discovered several genetic markers associated with bone mineral accrual, which could ultimately help identify causes of eventual osteoporosis earlier in life through genetic testing.

6 Jan 2021

First steps toward uncovering CRISPR/Cas gene doping in plasma

All athletes want to be at the top of their game when they compete, but some resort to nefarious approaches to achieve peak muscle growth, speed and agility. Recent developments in gene editing technology could tempt athletes to change their DNA to get an edge.

6 Jan 2021

Groundbreaking research project shows how brain health can traverse generations

Your father's exercise routine may have made you smarter according to EU-funded researchers studying how lifestyle choices affect brain function and memory. The findings could lead to new treatments for neurodegenerative conditions such as Alzheimer's disease.

5 Jan 2021

Researchers resolve mysteries about the function of key gene-silencing protein

A long-running debate over how an important gene-silencing protein identifies its targets has been resolved by researchers at Massachusetts General Hospital (MGH).

4 Jan 2021

Researchers develop a gene signature for predicting survival in patients with peritoneal carcinomatosis

Researchers from The University of Texas MD Anderson Cancer Center who profiled more than 45,000 individual cells from patients with peritoneal carcinomatosis (PC), a specific form of metastatic gastric cancer, defined the extensive cellular heterogeneity and identified two distinct subtypes correlated with patient survival.

4 Jan 2021

Scientists trace genetic roots of Chiari 1 malformation

About one in 100 children has a common brain disorder called Chiari 1 malformation, but most of the time such children grow up normally and no one suspects a problem.

28 Dec 2020

Polygenic risk scores from multi-population data could improve IBD predictions

Using genetic data from nearly 30,000 people, Mount Sinai researchers have built risk scores from a combination of datasets representing distinct ancestral populations that improve prediction of risk for inflammatory bowel diseases (IBD) including Crohn's disease and ulcerative colitis. The study was published in Gastroenterology on December 24.

24 Dec 2020

Researchers discover how shattered chromosomes make cancer cells more aggressive

Cancer is one of the world's greatest health afflictions because, unlike some diseases, it is a moving target, constantly evolving to evade and resist treatment.

23 Dec 2020

Researcher discovers seven DNA fingerprints that define cancer risk

Lifestyle, or put another way 'bad habits', is one of the textbook explanations for why some people are at higher risk for cancer.

23 Dec 2020

Study presents novel gene therapy for deafness

A new study from Tel Aviv University presents an innovative treatment for deafness, based on the delivery of genetic material into the cells of the inner ear.

23 Dec 2020

Forward genetics used to identify gene linked to autism spectrum disorder

UT Southwestern scientists have adapted a classic research technique called forward genetics to identify new genes involved in autism spectrum disorder (ASD).

23 Dec 2020

Researchers discover protein that adjusts gene activity to match nutrient levels in roundworms

Transforming a fertilized egg into a fully functional adult is a complicated task. Cells must divide, move, and mature at specific times. Developmental genes control that process, turning on and off in a choreographed way.

23 Dec 2020

Transcription factors in the brain strongly correlate with the behavior of honey bees

An unusual study that involved bar coding and tracking the behavior of thousands of individual honey bees in six queenless bee hives and analyzing gene expression in their brains offers new insights into how gene regulation contributes to social behavior.

23 Dec 2020

Study highlights the far-reaching effects of mutagenic compounds on human health

In order to survive, flourish and successfully reproduce, organisms rely on a high degree of genetic stability. Mutagenic agents, which can threaten the integrity of the genetic code by causing mutations in DNA, pose a serious risk to human health.

21 Dec 2020

Study provides new insights into the molecular underpinnings of Duchenne muscular dystrophy

A UT Southwestern research team has catalogued gene activity in the skeletal muscle of mice, comparing healthy animals to those carrying a genetic mutation that causes Duchene muscular dystrophy (DMD) in humans.

21 Dec 2020

Researchers use precision medicine strategy to identify a new genetic skeletal disorder

Researchers of the "Cell Biology and Physiology-LABRET" group of the University of Malaga (UMA), together with the Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), have described a new genetic skeletal disorder based on a precision medicine strategy.

21 Dec 2020

Pig stem cells offer a new way to grow human organs for transplantation

In a new paper published in Stem Cell Reports, Bhanu Telugu and co-inventor Chi-Hun Park of the University of Maryland (UMD) Department of Animal and Avian Sciences show for the first time that newly established stem cells from pigs, when injected into embryos, contributed to the development of only the organ of interest (the embryonic gut and liver), laying the groundwork for stem cell therapeutics and organ transplantation.

18 Dec 2020

Researchers discover cells responsible for resistance to T-ALL treatment

T-cell acute lymphoblastic leukemia (T-ALL) is a cancer of the blood that affects mainly children, but also less frequently adults. In adults, although the response to treatment might be initially positive, relapses are common and have a poor prognosis.

17 Dec 2020

A new approach to identify genomic regions in our brain that contribute to make us human

With only 1% difference, the human and chimpanzee protein-coding genomes are remarkably similar.

16 Dec 2020

Genomics

Researchers examine the role of Shiga toxin in the immune system

Researchers discover many genetic markers related to bone mineral accrual

First steps toward uncovering CRISPR/Cas gene doping in plasma

Groundbreaking research project shows how brain health can traverse generations

Researchers resolve mysteries about the function of key gene-silencing protein

Researchers develop a gene signature for predicting survival in patients with peritoneal carcinomatosis

Scientists trace genetic roots of Chiari 1 malformation

Polygenic risk scores from multi-population data could improve IBD predictions

Researchers discover how shattered chromosomes make cancer cells more aggressive

Researcher discovers seven DNA fingerprints that define cancer risk

Study presents novel gene therapy for deafness

Forward genetics used to identify gene linked to autism spectrum disorder

Researchers discover protein that adjusts gene activity to match nutrient levels in roundworms

Transcription factors in the brain strongly correlate with the behavior of honey bees

Study highlights the far-reaching effects of mutagenic compounds on human health

Study provides new insights into the molecular underpinnings of Duchenne muscular dystrophy

Researchers use precision medicine strategy to identify a new genetic skeletal disorder

Pig stem cells offer a new way to grow human organs for transplantation

Researchers discover cells responsible for resistance to T-ALL treatment

A new approach to identify genomic regions in our brain that contribute to make us human

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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