Genomics

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DNA misfolding linked to heightened risk for Type 1 diabetes

It's known that genetics, or an inherited genome, is a major determinant of one's risk for autoimmune diseases, like Type 1 diabetes. In human cells, a person's genome--about six feet of DNA--is compressed into the micrometer space of the nucleus via a three-dimensional folding process.

11 Feb 2020

Pioneering project on genomic edition through CRISPR/Cas9 to study early embryonic development

Characterization studies of early embryonic development are limited, mainly due to the lack of samples and the obvious legal and ethical limitations.

11 Feb 2020

New mechanism for repair of chromosomal breaks

Chromosomal breaks are the most harmful damage for cells. If they are not repaired, they block the duplication and segregation of chromosomes, stop the growth cycle and cause cell death. These breaks appear frequently in tumor cells and are produced spontaneously during the replication of genetic material.

10 Feb 2020

Bayer and Meiogenix join forces to advance agricultural research and development

Bayer and Meiogenix, a biotech company focused on next-generation breeding technologies, announced today a collaboration to advance agricultural research and development by accelerating the development of Meiogenix's proprietary technologies related to plant breeding and genome editing applications.

From Bayer AG 10 Feb 2020

Scientists come together to better understand patented innovations available for gene therapy

The global gene therapy market is expected to reach $13 billion by 2024 as new treatment options target cancers and other diseases.

9 Feb 2020

Biological toolkit will help researchers design new functions in mammalian cells

A new synthetic biology toolkit developed at Northwestern University will help researchers design mammalian cells with new functionalities.

9 Feb 2020

Rhizosphere microbiome can systemically shape and control root exudation

Roots are plant organs, that typically absorb water and minerals from soil. It is lesser known that roots also secrete metabolites, so-called root exudates, which impact the properties of soil directly around the root.

9 Feb 2020

Princeton's Bonnie Bassler awarded the 2020 Gruber Genetics Prize

The 2020 Gruber Genetics Prize is being awarded to geneticist Bonnie Bassler, Ph.D. of Princeton University and the Howard Hughes Medical Institute, for her groundbreaking work on how bacteria "talk" to each other using molecular "languages."

9 Feb 2020

Genomic sequencing technique helps understand gut microbiota one cell at a time

A population of microorganisms living in our intestine, known as the gut microbiota, plays a crucial role in controlling our metabolism and reducing the risk of conditions such as obesity and diabetes.

9 Feb 2020

Research provides new insights into molecular basis of X-chromosome inactivation

Researchers at the European Molecular Biology Laboratory in Heidelberg and Institut Curie in Paris have shown that the protein SPEN plays a crucial role in the process of X-chromosome inactivation, whereby female mammalian embryos silence gene expression on one of their two X chromosomes.

7 Feb 2020

Defining neurogenic niche proteome helps identify key regulators of neurogenesis

In mammalian adult brains, neural stem cells are only present in few specific parts, so called niches. Only these niches are capable of generating new neurons.

7 Feb 2020

Genetic fingerprints could help identify cancer-causing culprits

Causes of cancer are being cataloged through an international study revealing the genetic fingerprints of DNA-damaging processes that drive cancer development.

6 Feb 2020

Study lays foundation for translating mitochondrial biology into clinical applications

A study led by The University of Texas MD Anderson Cancer Center furthered understanding about mitochondria, the cell components known as the "powerhouse of the cell." Knowing more about the genome is crucial given that mitochondria play important roles in tumorigenesis.

6 Feb 2020

Researchers discover new mutational phenomenon chromothripsis in cancer

Researchers at Harvard Medical School and EMBL-EBI have carried out the largest analysis across cancer types of the newly discovered mutational phenomenon chromothripsis.

6 Feb 2020

New insight into genomic alterations associated with telomere maintenance mechanisms in cancer

To gain an infinite lifespan, cancer cells need to maintain the ends of their chromosomes, known as telomeres. They achieve this in various different ways.

6 Feb 2020

Analyzing cancer-specific alterations found in tumor's RNA

Researchers at EMBL-EBI were among the leaders of a large international consortium that carried out a joint analysis of data from over 1000 donors of more than 25 cancer types, studying data on their whole genomes along with tumor transcriptome data, which indicates the genes that are active within a tumor.

6 Feb 2020

Researchers study how structural variations in the genome can lead to cancer

Structural variations in genomes can arise from deleting, amplifying, or reordering genomic segments ranging from a few thousand letters of the genetic code to whole chromosomes.

6 Feb 2020

First comprehensive survey of viruses found within different cancers

Researchers from the University of East Anglia have helped to carry out the first comprehensive survey of viruses found within different types of cancer.

5 Feb 2020

Cancer mutations may arise decades before diagnosis

Researchers at EMBL's European Bioinformatics Institute and the Francis Crick Institute have analyzed the whole genomes of over 2600 tumors from 38 different cancer types to determine the chronology of genomic changes during cancer development.

5 Feb 2020

Researchers discover new genetic drivers of cancer

The discovery of genetic drivers of cancer can have critical implications for the diagnosis and treatment of cancer patients, yet genome analysis has focused primarily on only 1-2% of the whole genome - the part that contains the code for making proteins.

5 Feb 2020

Genomics

DNA misfolding linked to heightened risk for Type 1 diabetes

Pioneering project on genomic edition through CRISPR/Cas9 to study early embryonic development

New mechanism for repair of chromosomal breaks

Bayer and Meiogenix join forces to advance agricultural research and development

Scientists come together to better understand patented innovations available for gene therapy

Biological toolkit will help researchers design new functions in mammalian cells

Rhizosphere microbiome can systemically shape and control root exudation

Princeton's Bonnie Bassler awarded the 2020 Gruber Genetics Prize

Genomic sequencing technique helps understand gut microbiota one cell at a time

Research provides new insights into molecular basis of X-chromosome inactivation

Defining neurogenic niche proteome helps identify key regulators of neurogenesis

Genetic fingerprints could help identify cancer-causing culprits

Study lays foundation for translating mitochondrial biology into clinical applications

Researchers discover new mutational phenomenon chromothripsis in cancer

New insight into genomic alterations associated with telomere maintenance mechanisms in cancer

Analyzing cancer-specific alterations found in tumor's RNA

Researchers study how structural variations in the genome can lead to cancer

First comprehensive survey of viruses found within different cancers

Cancer mutations may arise decades before diagnosis

Researchers discover new genetic drivers of cancer

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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