Genomics

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Princeton researchers find link between microbes and cancers in threatened California foxes

Can staph microbes lead to cancer? Microbes are known to affect digestion, mood and overall health, and now Princeton researchers have shown that a shift in the microbiome is linked to cancer -- at least in a threatened subspecies of foxes found only on one island off the California coast.

4 Feb 2020

Study uncovers more pieces of the autism puzzle

A major international study from the Autism Sequencing Consortium with participation of researchers from the Danish iPSYCH psychiatry project, has recently mapped 102 new autism genes.

4 Feb 2020

Developing tests for genetic signs could lead to earlier cancer detection

Early signs of cancer can appear years before diagnosis and developing tests for these genetic signs could provide new ways to spot cancer early, according to new research led by the Crick and EMBL-EBI, and supported by an international cancer genomics consortium, the Pan-Cancer Analysis of Whole Genomes Project.

4 Feb 2020

DNA extracted from museum specimens can provide genetic information

DNA in preserved museum specimens can allow scientists to explore the history of species and humanities impact on the ecosystem, but samples are typically preserved in formaldehyde which can damage DNA and make it very difficult to recover.

4 Feb 2020

Research group examines differences in antibiotic resistance between the gut and mouth microbiome

The threat of antimicrobial resistance to medication is a global health issue. Recent years have seen a surge in our awareness of resistance genes; and as a result of the prevalence of these genes, antibiotics are becoming less effective at treating microbial infections, such as TB and gonorrhea.

4 Feb 2020

Single-cell DNA assessment method can detect fetal genetic abnormalities

Non-invasive prenatal tests are used for fetal genetic disease screening in pregnant women. In contrast, invasive tests like amniocentesis carry the risk of causing fetal harm.

4 Feb 2020

New technology provides point of care insights to Rush oncologists

Rush University Medical Center is the first health care organization to launch medical record company Epic's module for genomic results, giving providers the tools they need to tailor patient care at the molecular level.

4 Feb 2020

Research may provide insight into evolution of human social life

A UTSA researcher has discovered that, whether in a pair or in groups, success in primate social systems may also provide insight into organization of human social life.

4 Feb 2020

Institut Pasteur's scientists isolate strains of coronavirus 2019-nCoV detected in France

As well as sequencing the whole genome of coronavirus 2019-nCoV, the Institut Pasteur continued to work on the samples taken from the first confirmed cases. The quality of these initial samples enabled rapid cell-culture isolation of the new virus.

3 Feb 2020

Japanese researchers identify genetic variations related to specific dietary habits

Researchers at the RIKEN Center for Integrative Medical Sciences in Japan and colleagues at Osaka University have found genetic variations in humans related to specific dietary habits.

29 Jan 2020

Research uncovers disease-aggravating mutation in mouse model of GRACILE syndrome

The new mitochondrial DNA (mtDNA) variant drastically speeds up the disease progression in a mouse model of GRACILE syndrome. This discovery provides a new tool for studies of mitochondrial diseases.

29 Jan 2020

Study uncovers molecular mechanism that triggers a rare type of muscular dystrophy

A study led by the IBB-UAB has identified the molecular mechanism through which a protein, when carrying genetic mutations associated with a rare disease known as limb-girdle muscular dystrophy, type 1G, accelerates its tendency to form amyloid fibrils and finally triggers the appearance of the disease.

29 Jan 2020

Researchers create new brain cancer model using genetically engineered pluripotent stem cells

Using genetically engineered human pluripotent stem cells, University of California San Diego School of Medicine researchers created a new type of cancer model to study in vivo how glioblastoma, the most common and aggressive form of brain cancer, develops and changes over time.

29 Jan 2020

New micro-scale technology holds promise for improved tumor diagnosis

Using a single-needle biopsy and new technology for tumor diagnosis developed by Baylor College of Medicine and the Broad Institute of MIT and Harvard, researchers have been able to provide a more detailed and wider window into cancer biology, tumor type and the mechanisms of response and resistance to therapy than with conventional approaches.

27 Jan 2020

New gene correction therapy for hereditary muscular disease among children

Duchenne type muscular dystrophy is the most common hereditary muscular disease among children, leaving them wheelchair-bound before the age of twelve and reducing life expectancy.

27 Jan 2020

Naturally produced protein suppresses breast cancer metastasis

A protein naturally produced in the body has been found to suppress breast cancer metastasis in animal models of human tumors. Researchers led by Baylor College of Medicine also found that high levels of this protein, AKAP8, predicts a better survival for breast cancer patients.

27 Jan 2020

Study tracks milestones in the history of human disease genetics

Genetic discoveries over the past 25 years have substantially advanced understanding of both rare and common diseases, furthering the development of treatment and prevention for ailments ranging from inflammatory bowel diseases to diabetes, according to a study published in Nature Research in January.

27 Jan 2020

ClinGen expert panel disputes nine genes linked to long QT syndrome

Geneticists and heart specialists around the world had previously reported 17 genes to cause long QT syndrome, a little-known inherited heart condition. However, the Clinical Genome Resource's expert panel has critically reevaluated the scientific evidence for all 17 reported genes, disputing nine of the genes and revealing only three of the genes to be definitively associated with the most common form of the disease.

27 Jan 2020

Determining Microsatellite Instability Status Using Multiplex PCR-Based Methods

Determining microsatellite instability status using multiplex PCR-based methods used to screen for Lynch Syndrome, a dominant hereditary cancer propensity.

From Promega Corporation 24 Jan 2020

Jumping genes play surprising role in stabilizing DNA folding patterns

"Jumping genes" -- bits of DNA that can move from one spot in the genome to another -- are well-known for increasing genetic diversity over the long course of evolution.

24 Jan 2020