Genomics

RSS

First bifacial molecule can invade double-stranded DNA or RNA

Carnegie Mellon University researchers have developed a synthetic molecule that can recognize and bind to double-stranded DNA or RNA under normal physiological conditions. The molecule could provide a new platform for developing methods for the diagnosis and treatment of genetic conditions.

13 Nov 2018

New study provides deeper insight into chromosome segregation during mitosis

When a cell divides—a process known as mitosis—its chromosomes need to be separated and evenly distributed into the newly created daughter cells. Although this is known to be extremely complicated and to feature a range of cellular components, many of its details remain unclear, which has hampered efforts to develop treatments for when mitosis goes awry.

12 Nov 2018

Failed DNA repair triggers chromosomal chaos in cancer cells

Researchers have established the trigger for catastrophic events that occur within the chromosomes of cancer cells and lead to cancer cell death.

12 Nov 2018

ChromDesign project trains budding scientists in 3D architecture of genome

How does the three-dimensional architecture of our genes affect the differentiation of cells and development of diseases? This is the question behind the European Innovation Training Network "ChromDesign- Chromatin and Design".

8 Nov 2018

Salk researchers solve genetic 'whodunnit' for cancer gene

Long thought to suppress cancer by slowing cellular metabolism, the protein complex AMPK also seemed to help some tumors grow, confounding researchers. Now, Salk Institute researchers have solved the long-standing mystery around why AMPK can both hinder and help cancer.

8 Nov 2018

Study explains how dermal fibroblasts age

With age, our tissues lose their function and capacity to regenerate after being damaged. A study published today in Cell by scientists at the Institute for Research in Biomedicine and the Centro Nacional de Análisis Genómico of the Center for Genomic Regulation explains how dermal fibroblasts age.

8 Nov 2018

CWRH/UH researcher receives grant to study role of KLF2 factor in vascular-related disorders

Transcription factors are proteins that determine whether specific genes are transcribed or not by binding to DNA. In other words, they help turn genes "on" or "off."

8 Nov 2018

Scientists discover new details about UHRF1 protein

Epigenetic changes often play an important role in cancer, because they cause the genetic material to be read incorrectly at certain locations. Genes that are especially critical are those that control the growth and death of cells.

7 Nov 2018

Geneticists decipher new gene responsible for rare form of hair loss

Hypotrichosis simplex leads to progressive hair loss already in childhood. A team of researchers led by human geneticists at the University Hospital of Bonn has now deciphered a new gene that is responsible for this rare form of hair loss.

6 Nov 2018

Genetic inhibition of SARM1 prevents axonal degeneration in nervous systems

Disarm Therapeutics, a biotechnology company creating a new class of disease-modifying therapeutics for patients with axonal degeneration, a central driver of neurological disease, today announced data demonstrating that genetic inhibition of SARM1 prevents axonal degeneration in the central, ocular and peripheral nervous systems.

5 Nov 2018

New research explains how large virus shells are formed

A virus, the simplest physical object in biology, consists of a protein shell called the capsid, which protects its nucleic acid genome -- RNA or DNA. The capsid can be cylindrical or conical in shape, but more commonly it assumes an icosahedral structure, like a soccer ball.

5 Nov 2018

Horizon Discovery collaborates with Biocartis to offer reference standards for new Idylla MSI assay

Horizon Discovery Group plc, a global leader in gene editing and gene modulation technologies, today announces that it has developed a set of precisely defined cell line-derived reference standards to support Biocartis’ recently launched Idylla™ microsatellite instability Assay.

From Revvity 5 Nov 2018

Scientists decode the longest ever continuous DNA sequence

Scientists have decoded the longest continuous DNA sequence to date, measuring around 10,000 times longer than normal sequencing reads.

1 Nov 2018

Researchers uncover confusion and gaps in study participants’ understanding of genetic privacy

Confusion and ambiguity in how U.S. patients and researchers perceive genetic privacy is uncovered by a study published October 31, 2018 in the open-access journal PLOS ONE by Ellen W. Clayton from Vanderbilt University, USA, and colleagues.

1 Nov 2018

CNIO researchers link MASTL protein to origin of thrombocytopenia

The Cell Division and Cancer Group of the Spanish National Cancer Research Centre has discovered that MASTL, the protein whose function in the organism has not yet been sufficiently investigated, plays an important role in controlling the cytoskeleton, the structure that gives shape to the cells, and enables their mobility and capacity for grouping.

1 Nov 2018

Genetic defect linked to ALS causes sugar-starved cells to overproduce lipids

A genetic defect tied to a variety of neurodegenerative diseases and mental illnesses changes how cells starved of sugar metabolize fatty compounds known as lipids, a new study led by researchers from the Johns Hopkins Bloomberg School of Public Health shows.

31 Oct 2018

Study explores impact of new Texas law HB 810 on stem cell interventions

A new study takes a close look at the content and potential implications of the new Texas law HB 810, which aims to expand assess of experimental stem cell interventions outside the realm of clinical trials under FDA oversight.

31 Oct 2018

Study: Single protein regulates network of genes essential for sperm development

A single protein regulates a battery of key genes inside developing sperm, according to a new study out of Case Western Reserve University School of Medicine.

31 Oct 2018

Growth of genomic databases hinders efforts to identify bacteria

There are many ways to slice and dice genomic data to identify a species of bacteria, or at least find its close relatives. But fast techniques to sequence genomes have flooded the public databases and in a biased fashion, containing lots of genomic data about some species and not enough about others, according to a Rice University computer scientist.

31 Oct 2018

Top researchers call for unified standards in 3D genome and epigenetic data

Studying the three-dimensional structure of DNA and its dynamics is revealing a lot of information about gene expression, expanding our knowledge of how cells, tissues and organs actually work in health and disease.

30 Oct 2018