Genomics

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Genome sequence cannot predict radiation resistance, say researchers

For the last two decades, researchers worldwide have been using whole genome sequencing to understand what makes cells radiation-resistant, hoping to solve an old biological mystery: why is it that one of the most radiation-resistant organisms, Deinococcus radiodurans, aka "Conan the bacterium," can survive hundreds of times more DNA damage caused by gamma rays than most other organisms? According to a study published recently in Standards of Genomic Sciences by researchers at the Uniformed Services University (USU), the amount of radiation a Deinococcus cell can survive in fact has little to do with the number and types of its DNA repair proteins.

11 Sep 2017

Researchers develop model to explore hard-to-study mutations in human genome

A team of researchers led by a bioinformatician at the University of California San Diego has developed a method to help determine whether certain hard-to-study mutations in the human genome, called short tandem repeats or microsatellites, are likely to be involved in harmful conditions.

11 Sep 2017

Fathers can influence offspring sex ratios, mice study shows

It has traditionally been thought that in mammals only mothers are able to influence the sex of their offspring.

11 Sep 2017

Machine learning and whole-genomic sequence data could predict physical traits including the face for identification study reveals

A study conducted by a team of researchers from Human Longevity, Inc. (HLI) found that whole-genome sequencing data and machine learning can be used in the prediction of individual faces and other physical traits.

8 Sep 2017

Seeing the full picture, real-time analysis of live-cells

Every cell is a miniature factory taking in raw material (extracellular signals) and processing it to produce something (a biological response). But unlike a factory that can be easily tweaked to run at steady-state and look the same from day to day, cells are dynamic.

From Sartorius 7 Sep 2017

Coimbra Pediatric Hospital selects Congenica's Sapientia software platform for In2Genome project

Congenica, a global provider of clinical genomics interpretation software, today announced a new customer partnership with the Coimbra Paediatric Hospital, a leading paediatric hospital in Portugal and part of the Coimbra Hospital and University Centre.

7 Sep 2017

New DNA sequencing technology measures effects of thousands of sequences on gene activity

When a gene is switched on, various stretches of DNA nearby act as 'control dials', influencing the level of activity and the amount of gene product that is made.

7 Sep 2017

Color perception of medaka fish varies according to seasonal changes, research finds

In many areas, the environment fluctuates greatly depending on the season, and animals living in those areas must adapt to the changing environment.

5 Sep 2017

Researchers decode complex finger millet genome in high quality for first time

Finger millet has two important properties: The grain is rich in important minerals and resistant towards drought and heat.

5 Sep 2017

Genetics of circadian rhythms found to have effect on migraine

People with a specific variation in the CLOCK gene have more migraines under financial stress. This work, the first time that the genetics of circadian rhythms has been shown to have an effect on migraine, is presented at the ECNP conference in Paris.

4 Sep 2017

Mutations altering gene function play role in development of intellectual disabilities

Intellectual disabilities are often caused by a mutation that damages a gene, preventing the associated protein from functioning properly.

1 Sep 2017

UAB researchers reveal key role for RSF1 protein in silencing genes

A fertilized human egg develops into multiple tissues, organs and about 200 distinct cell types. Each cell type has the same genes, but they are expressed differently during development and in mature cells.

31 Aug 2017

Genetics of digestion stayed remarkably the same from fishes to humans, research shows

Scientists have discovered a network of genes and genetic regulatory elements in the lining of the intestines that has stayed remarkably the same from fishes to humans. Many of these genes are linked to human illnesses, such as inflammatory bowel diseases, diabetes and obesity.

30 Aug 2017

Scientists identify novel role for retrotransposons in shaping embryonic chromatin landscape

Retrotransposons are repetitive elements that form almost half of the mammalian genome. Even though they are so common, they have previously been considered to be fairly insignificant.

30 Aug 2017

Collaborative project reaches milestone halfway point in constructing Kinase Chemogenomic Set

The Structural Genomics Consortium at the University of North Carolina at Chapel Hill (SGC-UNC), in partnership with the DiscoverX Corporation, has reached the milestone halfway point in its development of the Kinase Chemogenomic Set, a potent group of inhibitors which allow deeper exploration of the human kinome, a family of enzymes critical to understanding human disease and developing new therapies.

26 Aug 2017

Scientists develop new system to identify and characterize regulatory DNA sequences

Scientists from the Children's Medical Center Research Institute at UT Southwestern have developed an innovative system to identify and characterize the molecular components that control the activities of regulatory DNA sequences in the human genome.

24 Aug 2017

JAX wins NIGMS funding to decipher role of RNA structure in gene regulation

With new funding from the National Institute of General Medical Sciences totaling $2,059,618 over five years, JAX Assistant Professor Zhengqing Ouyang, Ph.D., will build a research program to reveal the roles of RNA structure in post-transcriptional regulation at the genome scale.

21 Aug 2017

Penn researchers receive two new post-doctoral training grants for genomic science

Researchers from the Perelman School of Medicine at the University of Pennsylvania have received two highly competitive post-doctoral Institutional Training Grants for genomic science from the National Human Genome Research Institute of the National Institutes of Health.

21 Aug 2017

Fruit flies' pheromones reveal sexual attractiveness of females

Life as a fruit fly seems pretty simple: Hatch, grow, eat some fruit, find a mate, produce hundreds of tiny offspring and die -- all in a month or so.

18 Aug 2017

Impaired DNA replication may lead to trans-generational inheritance of epigenetic changes

Scientists reveal that a fault in the process that copies DNA during cell division can cause epigenetic changes that may be inherited for up-to five generations.

17 Aug 2017

Genomics

Genome sequence cannot predict radiation resistance, say researchers

Researchers develop model to explore hard-to-study mutations in human genome

Fathers can influence offspring sex ratios, mice study shows

Machine learning and whole-genomic sequence data could predict physical traits including the face for identification study reveals

Seeing the full picture, real-time analysis of live-cells

Coimbra Pediatric Hospital selects Congenica's Sapientia software platform for In2Genome project

New DNA sequencing technology measures effects of thousands of sequences on gene activity

Color perception of medaka fish varies according to seasonal changes, research finds

Researchers decode complex finger millet genome in high quality for first time

Genetics of circadian rhythms found to have effect on migraine

Mutations altering gene function play role in development of intellectual disabilities

UAB researchers reveal key role for RSF1 protein in silencing genes

Genetics of digestion stayed remarkably the same from fishes to humans, research shows

Scientists identify novel role for retrotransposons in shaping embryonic chromatin landscape

Collaborative project reaches milestone halfway point in constructing Kinase Chemogenomic Set

Scientists develop new system to identify and characterize regulatory DNA sequences

JAX wins NIGMS funding to decipher role of RNA structure in gene regulation

Penn researchers receive two new post-doctoral training grants for genomic science

Fruit flies' pheromones reveal sexual attractiveness of females

Impaired DNA replication may lead to trans-generational inheritance of epigenetic changes

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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