Genomics

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3D structure of a probable precursor to the CRISPR-Cas12 enzyme revealed

Gene editing is one of the latest breakthroughs in biology. The widely known CRISPR-Cas gene editing system provided prokaryotes (organisms that lack cell nuclei) an immunity against foreign DNA. Since the discovery of the CRISPR gene editing technology, scientists are revealing the evolution of the CRISPR-Cas proteins from their precursors.

7 Apr 2023

New method estimates mutation risks due to residual radiation from the Fukushima nuclear disaster

Ionizing radiation from nuclear disasters are known to be harmful to the natural environment. The Fukushima Dai-ichi Nuclear Power Plant meltdown that occurred in 2011 is a prominent example of such a disaster in recent memory.

7 Apr 2023

Virginia Tech to study the regulation of genes responsible for cannabinoid biosynthesis

Industrial cultivation of hemp is seeing a massive expansion in the United States due to new federal laws and consumer demand.

6 Apr 2023

Researchers discover and characterize a novel protein involved in tumor suppression mechanism

Understanding how cancer develops is critical for designing effective, personalized cancer therapies. Researchers have known for years that cancer begins with mutations in certain types of genes.

6 Apr 2023

Understanding how surface factors influence or inhibit biofilm formation in the presence of antibiotics

Similar to how cells within human tissues communicate and function together as a whole, bacteria are also able to communicate with each other through chemical signals, a behavior known as quorum signaling (QS).

5 Apr 2023

SFU researchers study pathogen genes to develop new drugs against bacterial infections

Researchers at Simon Fraser University are studying the genes of superbugs to aid the development of new and effective treatments for drug-resistant bacterial infections.

5 Apr 2023

St. Jude computational biologists characterize the full spectrum of oncogenic fusions in pediatric cancer

The scientific foundation needed to work on curing a class of cancer-causing mutations is here, in the form of a tool from St. Jude Children's Research Hospital.

5 Apr 2023

Researchers develop a method for making “mini-heart” using pluripotent stem cells

A team at the Technical University of Munich has induced stem cells to emulate the development of the human heart.

5 Apr 2023

Mosaic Therapeutics closes $28m series A funding and appoints Brian Gladsden as CEO

Mosaic Therapeutics, an oncology therapeutics company dedicated to resolving cancer’s complexity to power new treatments for patients, today announced the close of its $28 million series A funding round.

From Mosaic Therapeutics 4 Apr 2023

CRISPR screens reveal genetic determinants of PARP inhibition in prostate cancer

Prostate cancer tumors harboring BRCA1/2 mutations are exceptionally sensitive to PARP inhibitors, while genomic alterations in other DNA damage response (DDR) genes are less responsive.

4 Apr 2023

New software tool uses genetic data to improve cancer modeling technology

Lifestyle behaviors such as eating well and exercising can be significant factors in one's overall health. But the risk of developing cancer is predominantly at the whim of an individual's genetics.

4 Apr 2023

Unique brain proteins may be critical regulators of body weight

Genetic factors could contribute to up to 50-75% of the variance in body mass index, or BMI, in the population.

4 Apr 2023

Endothelial deletion of the Wt1 gene affects coronary vessel formation and myocardial development

How is the mammals' heart formed? What role do endothelial cells play? Do the same pathways and genes involved in the formation of the embryonic heart also play a role in repair processes?

4 Apr 2023

Increased expression of collagens can drive longer lifespan at warm temperatures

Researchers have long known that many animals live longer in colder climates than in warmer climates.

4 Apr 2023

N-abling the acceleration of the life sciences through precision dispensing

In this interview, we speak to Holger Eickhoff, CEO and Founder of Scienion, about their latest technology, The Nucleus Automation Ecosystem.

From SCIENION GmbH 4 Apr 2023

Study elucidates the genetics of preterm birth and pregnancy length

New knowledge of the genetic factors behind premature delivery and gestational duration has now emerged.

3 Apr 2023

BU researcher wins $3.9 million NIH grant to develop novel therapeutic modalities for Alzheimer's

Julia TCW, PhD, assistant professor of pharmacology & experimental therapeutics at Boston University Chobanian & Avedisian School of Medicine, has received a five-year, $3.9 million grant from the National Institutes of Health's National Institute on Aging.

3 Apr 2023

Yale-led team creates new resource that is an important step toward personalized care

Each person has about 4 million sequence differences in their genome relative to the reference human genome.

3 Apr 2023

Cold temperature plays a central role in longevity

Cold activates a cellular cleansing mechanism that breaks down harmful protein aggregations responsible for various diseases associated with aging.

3 Apr 2023

Transposable elements in various cancers could be used to harness novel immunotherapies

New research from Washington University School of Medicine in St. Louis suggests that transposable elements in various cancers potentially may be used to harness novel immunotherapies against tumors that don't typically respond to immune-based treatments. Shown is a 3D rendering of cancer cells.

31 Mar 2023

Genomics

3D structure of a probable precursor to the CRISPR-Cas12 enzyme revealed

New method estimates mutation risks due to residual radiation from the Fukushima nuclear disaster

Virginia Tech to study the regulation of genes responsible for cannabinoid biosynthesis

Researchers discover and characterize a novel protein involved in tumor suppression mechanism

Understanding how surface factors influence or inhibit biofilm formation in the presence of antibiotics

SFU researchers study pathogen genes to develop new drugs against bacterial infections

St. Jude computational biologists characterize the full spectrum of oncogenic fusions in pediatric cancer

Researchers develop a method for making “mini-heart” using pluripotent stem cells

Mosaic Therapeutics closes $28m series A funding and appoints Brian Gladsden as CEO

CRISPR screens reveal genetic determinants of PARP inhibition in prostate cancer

New software tool uses genetic data to improve cancer modeling technology

Unique brain proteins may be critical regulators of body weight

Endothelial deletion of the Wt1 gene affects coronary vessel formation and myocardial development

Increased expression of collagens can drive longer lifespan at warm temperatures

N-abling the acceleration of the life sciences through precision dispensing

Study elucidates the genetics of preterm birth and pregnancy length

BU researcher wins $3.9 million NIH grant to develop novel therapeutic modalities for Alzheimer's

Yale-led team creates new resource that is an important step toward personalized care

Cold temperature plays a central role in longevity

Transposable elements in various cancers could be used to harness novel immunotherapies

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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