Genomics

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Scientists describe dynamic genomic landscape of tumor heterogeneity in hepatocellular carcinoma

Clinician scientists and scientists from the National Cancer Centre Singapore and A*STAR's Genome Institute of Singapore, in collaboration with Singapore General Hospital, the National University Health System, Duke-NUS Medical School, Nanyang Technological University, and collaborators from China, Malaysia, Thailand and the Philippines, have described a dynamic genomic landscape of tumour heterogeneity in hepatocellular carcinoma (HCC).

13 Dec 2021

Diversity in genetic data improves the ability to predict high cholesterol risk

Including data from people of diverse ancestries substantially improves certain genetic risk predictions in all populations, according to a study that examined the genes responsible for regulating blood cholesterol levels.

13 Dec 2021

Statistical model builds SARS-CoV-2 interactome with miRNAs, protein-coding genes, and co-infecting microbes

A team of researchers recently developed a statistical modeling method known as multiple-layer crosstalk (MLCrosstalk).

12 Dec 2021

Researchers discover mechanism for congenital disorders of glycosylation

Greenwood Genetic Center researchers are reporting the discovery of a mechanism that contributes to the tissue phenotypes seen in PMM2-CDG, the most common of the congenital disorders of glycosylation (CDGs).

8 Dec 2021

Diverse genome sequences generate a polygenic risk score to predict heart disease risk

In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein cholesterol levels, a major risk factor for heart disease.

8 Dec 2021

CRISPR/Cas9 gene editing enables sonodynamic therapy to effectively shrink tumors

Sonodynamic therapy uses ultrasound in combination with drugs to release harmful reactive oxygen species (ROS) at the site of a tumor.

8 Dec 2021

ORF10 protein mutations alter SARS-CoV-2 pathogenicity

Researchers examine 140 unique SARS-CoV-2 ORF10 sequences among 202,968 ORF10 retrieved sequences.

7 Dec 2021

Genome sequencing efforts overlook huge swathes of diversity and opportunity, researchers warn

Efforts to sequence the genomes of the world's animals tend to focus on those that most resemble humans with the work conducted almost entirely in the Global North, according to an analysis led by Washington State University.

7 Dec 2021

Researchers use gene-editing to create single sex mice litters

Scientists at the Francis Crick Institute, in collaboration with University of Kent, have used gene editing technology to create female-only and male-only mice litters with 100% efficiency.

6 Dec 2021

Gene expression related to liver metabolism altered by spaceflight

The latest findings of a series of studies on mice that examined harmful effects caused by spending time in space show that gene expression related to liver metabolism is altered in response to the space environment.

6 Dec 2021

Study documents and visualizes hearing loss-associated genes in the inner ear

Researchers from Uppsala University have been able to document and visualise hearing loss-associated genes in the human inner ear, in a unique collaboration study between otosurgeons and geneticists.

2 Dec 2021

Genetic variant found in Old Order Amish may confer protective effects against cardiovascular disease

Whole-exome sequencing and association analysis in nearly 7,000 Old Order Amish reveals a genetic variant that may confer protective effects against cardiovascular disease (CVD), researchers report.

2 Dec 2021

Large study of plasma proteome unravels its genetic determinants and relationship with human disease

In a study published today in Nature Genetics, scientists at deCODE genetics , a subsidiary of the pharmaceutical company Amgen, demonstrate how measuring the levels of a large number of proteins in plasma at population scale when combined with data on sequence diversity and RNA expression dramatically increases insights into human diseases and other phenotypes.

2 Dec 2021

New method can precisely, rapidly correct genetic alterations in patient cells

Researchers in the University of Helsinki and University Hospital Helsinki have developed a method to precisely and rapidly correct genetic alterations in the cultured patient cells.

30 Nov 2021

Host and in vitro genomic variability of SARS-CoV-2 and its variants

Researchers from the University of Sydney investigate the genomic variability of SARS-CoV-2 within the host and in vitro.

30 Nov 2021

Researchers dissect the shared genetic architecture of suicide attempts and psychiatric disorders

In the largest genetic study of suicide attempts to date, researchers have identified a region of the genome on chromosome 7 containing DNA variations that increase the risk that a person will attempt suicide.

30 Nov 2021

New method helps correct genetic alterations in the cultured patient cells rapidly

Researchers in the University of Helsinki and University Hospital Helsinki have developed a method to precisely and rapidly correct genetic alterations in the cultured patient cells.

30 Nov 2021

New phenotype of LRP6 mutation reported for the first time in patients with tooth agenesis

A group led by Prof. Han Dong of Peking University School of Stomatology reported for the first time hand preaxial polydactyly in patients with tooth agenesis carrying a previously unknown mutation of low-density lipoprotein receptor-related protein 6 (LRP6).

29 Nov 2021

Rare variants in high-risk autism gene can alter architecture and organization of neurons, study finds

Scientists at the University of North Carolina at Chapel Hill School of Medicine and colleagues have demonstrated that rare variants in the ANK2 gene, consistently found in individuals with autism spectrum disorder (ASD), can alter architecture and organization of neurons, potentially contributing to autism and neurodevelopmental comorbidities.

29 Nov 2021

Genetic variations affect and rewire phosphorylation signaling networks in SARS-CoV-2 infection

Researchers study human single nucleotide variants (SNVs) using machine learning to identify amino acid changes that alter kinase-bound sequence motifs.

29 Nov 2021

Genomics

Scientists describe dynamic genomic landscape of tumor heterogeneity in hepatocellular carcinoma

Diversity in genetic data improves the ability to predict high cholesterol risk

Statistical model builds SARS-CoV-2 interactome with miRNAs, protein-coding genes, and co-infecting microbes

Researchers discover mechanism for congenital disorders of glycosylation

Diverse genome sequences generate a polygenic risk score to predict heart disease risk

CRISPR/Cas9 gene editing enables sonodynamic therapy to effectively shrink tumors

ORF10 protein mutations alter SARS-CoV-2 pathogenicity

Genome sequencing efforts overlook huge swathes of diversity and opportunity, researchers warn

Researchers use gene-editing to create single sex mice litters

Gene expression related to liver metabolism altered by spaceflight

Study documents and visualizes hearing loss-associated genes in the inner ear

Genetic variant found in Old Order Amish may confer protective effects against cardiovascular disease

Large study of plasma proteome unravels its genetic determinants and relationship with human disease

New method can precisely, rapidly correct genetic alterations in patient cells

Host and in vitro genomic variability of SARS-CoV-2 and its variants

Researchers dissect the shared genetic architecture of suicide attempts and psychiatric disorders

New method helps correct genetic alterations in the cultured patient cells rapidly

New phenotype of LRP6 mutation reported for the first time in patients with tooth agenesis

Rare variants in high-risk autism gene can alter architecture and organization of neurons, study finds

Genetic variations affect and rewire phosphorylation signaling networks in SARS-CoV-2 infection

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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