Histology & Microscopy

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Scientists elucidate the structure of protein complex essential for proper functioning of cells

Scientists at IST Austria describe for the first time the structure of a protein complex essential for our cells to function properly.

7 Oct 2021

Machine learning and high-powered microscopes provide detailed snapshots of cells' inner machinery

Open any introductory biology textbook, and you'll see a familiar diagram: A blobby-looking cell filled with brightly colored structures – the inner machinery that makes the cell tick.

6 Oct 2021

Novel technique enables 3D visualization of cells containing melanin pigment

To understand the biological underpinnings of skin and hair pigmentation and related diseases such as albinism or melanoma, scientists and doctors need quantitative, three-dimensional information about the architecture, content and location of pigment cells. Penn State College of Medicine researchers have developed a new technique that allows scientists to visualize every cell containing melanin pigment in 3D, in whole zebrafish.

6 Oct 2021

Researchers solve 3D structure of supramolecular protein nanoparticle using cryo-electron microscopy

Nanoparticles and nanocages are attractive materials that may be applied in color agents, catalysts, and drug delivery. For real-world use, it is necessary to produce a large number of nanoparticles of uniform size and shape, but thus far, nanoparticle formation methods using metals have been widely researched, and the formation of nanoparticles with a certain shape and size have been realized.

6 Oct 2021

New 'reporter viruses' make it easier to observe SARS-CoV-2 in real time

A version of SARS-CoV-2, the virus that causes COVID-19 disease, has been successfully modified to glow brightly in cells and animal tissues, providing a real-time way to track the spread and intensity of viral infection as it happens in animal models, researchers at Texas Biomedical Research Institute report in the journal The Proceedings of the National Academy of Sciences.

27 Sep 2021

New 3D pancreatic cancer model could be used to develop and test targeted treatments

An international team of scientists have created a three-dimensional (3D) pancreatic cancer tumour model in the laboratory, combining a bioengineered matrix and patient-derived cells that could be used to develop and test targeted treatments.

24 Sep 2021

Researchers unravel the structure of bacterial appendages

A research team led by David Thanassi, PhD, of Stony Brook University, has used molecular biology and cryoelectron microscopy to successfully unravel the structure of bacterial appendages called P pili.

22 Sep 2021

Study paves the way for development of novel delivery systems to suppress HIV

In a new study supported by the National Institutes of Health, researchers used exosomes, tiny nanoparticles capable of being taken up by cells, to deliver novel protein into the cells of mice infected with HIV. The protein attached to HIVs' genetic material and prevented it from replicating, resulting in reduced levels of HIV in the bone marrow, spleen, and brain.

21 Sep 2021

New automated computer program can accurately count micronuclei in cells

Micronuclei, which are small nucleus-like structures within cells, are commonly associated with tumors. Now, researchers from Tsukuba, Japan have developed an automated computer program that can accurately and reproducibly count these structures from microscope images, which will increase the speed and accuracy of micronuclei research.

18 Sep 2021

Research could help design peptides to halt antibiotic-resistant bacteria

Peptides could be primed to solve the knotty problem of antibiotic resistance among humans. Rice University scientists believe they can help.

17 Sep 2021

Unique imaging technique sheds light on how cells related to IBD affect intestinal tissues

New "maps" of hundreds of thousands of cells related to inflammatory bowel disease shed greater light on their effects on intestinal tissues through a newly utilized imaging technique called "imaging mass cytometry."

16 Sep 2021

Study provides the most detailed view of how ribosomes are assembled in human cells

All cells need ribosomes to make the proteins necessary for life. These multi-component molecular machines build complex proteins by stitching building blocks together according to instructions encoded in the cell's messenger RNAs.

16 Sep 2021

Novel method enables 3D imaging of human organs with micrometer precision

Researchers at Umeå University, Sweden, now demonstrate a method by which specific cell types in human organs can be studied with micrometer precision.

13 Sep 2021

Microscopy paired with AI leads to a fast, accurate, and cost-effective COVID-19 test

Beckman researchers paired microscopy with artificial intelligence to develop a COVID-19 test that's fast, accurate, and cost-effective. All we need to do is say "ahh."

12 Sep 2021

Scientists model the process of capsid disassembly in hepatitis B virus at atomic level

With up to 2.4 million U.S. cases and over 250 million chronic cases globally, hepatitis B infection persists despite the availability of a vaccine.

8 Sep 2021

Neuroscientists visualize ultrastructural changes to dendritic spines during structural plasticity

Researchers at the Max Planck Florida Institute for Neuroscience have developed a new imaging technique capable of visualizing the dynamically changing structure of dendritic spines with unprecedented resolution.

6 Sep 2021

Researchers develop brain organoids that show neural activity similar to living human brains

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed brain organoids -; 3D, brain-like structures grown from human stem cells -; that show organized waves of activity similar to those found in living human brains.

24 Aug 2021

ICL fluorescent label homogenously penetrates the glioblastoma brain tumors

Fluorescent indocarbocyanine lipid (ICL) shows much better distribution within glioblastoma brain tumors compared to fluorescent phospholipids, according to a study published in ACS Nano.

23 Aug 2021

New analytical method visualizes cell functions in vasculature-on-a-chip

A microphysiological system (MPS), also known as an organ-on-a-chip, is a 3D organ construct using human cells that help reveal how organs respond to drugs and environmental stimuli.

20 Aug 2021

Videos capture the inexorable spread of SARS-CoV-2 in live animals

Video images capture for the first time in live animals the inexorable spread of the COVID-19 virus, tracking the infection as it moved from the noses of mice to the lungs and other organs over the course of six days, in a new study led by researchers at Yale and Université de Montréal.

18 Aug 2021

Histology & Microscopy

Scientists elucidate the structure of protein complex essential for proper functioning of cells

Machine learning and high-powered microscopes provide detailed snapshots of cells' inner machinery

Novel technique enables 3D visualization of cells containing melanin pigment

Researchers solve 3D structure of supramolecular protein nanoparticle using cryo-electron microscopy

New 'reporter viruses' make it easier to observe SARS-CoV-2 in real time

New 3D pancreatic cancer model could be used to develop and test targeted treatments

Researchers unravel the structure of bacterial appendages

Study paves the way for development of novel delivery systems to suppress HIV

New automated computer program can accurately count micronuclei in cells

Research could help design peptides to halt antibiotic-resistant bacteria

Unique imaging technique sheds light on how cells related to IBD affect intestinal tissues

Study provides the most detailed view of how ribosomes are assembled in human cells

Novel method enables 3D imaging of human organs with micrometer precision

Microscopy paired with AI leads to a fast, accurate, and cost-effective COVID-19 test

Scientists model the process of capsid disassembly in hepatitis B virus at atomic level

Neuroscientists visualize ultrastructural changes to dendritic spines during structural plasticity

Researchers develop brain organoids that show neural activity similar to living human brains

ICL fluorescent label homogenously penetrates the glioblastoma brain tumors

New analytical method visualizes cell functions in vasculature-on-a-chip

Videos capture the inexorable spread of SARS-CoV-2 in live animals

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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