Histology & Microscopy

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X-ray laser offers new insights into how radiation damage occurs in biological tissue

An international research team has used the X-ray laser European XFEL to gain new insights into how radiation damage occurs in biological tissue.

6 Dec 2021

Novel approach uses PSOCT to non-invasively image the depth-resolved collagen organization

Collagen is essential for tissue integrity and stability, and changes in its intrinsic organization are the key features in several important diseases such as scar formation, heart infarction and cancers.

29 Nov 2021

The mode of action of essential proteins involved in cancer and Alzheimer´s deciphered

The proteins that belong to the HAT family are essential for life as they transport amino acids across the cell membrane. Although the members of this family are practically identical, some transport certain amino acids and not others.

29 Nov 2021

New technique may be a significant leap forward in the understanding of human cells

Most human diseases can be traced to malfunctioning parts of a cell — a tumor is able to grow because a gene wasn't accurately translated into a particular protein or a metabolic disease arises because mitochondria aren't firing properly, for example. But to understand what parts of a cell can go wrong in a disease, scientists first need to have a complete list of parts.

24 Nov 2021

Novel method enables deeper analysis of endocrine disrupting chemicals' impact on gene expression

When something disrupts hormone binding to the receptor, such as environmental compounds or pollutants, called endocrine disrupting chemicals (EDCs), the results can be harmful and, in some cases, lead to certain forms of cancer.

24 Nov 2021

New "image analysis pipeline" provides insight into how disease changes the body

A new "image analysis pipeline" is giving scientists rapid new insight into how disease or injury have changed the body, down to the individual cell.

24 Nov 2021

Cryo-EM reveals how the DNA replication machinery assembles at DNA damage sites

Cryogenic electron microscopy (cryo-EM) has enabled researchers to study how the DNA replication machinery assembles at sites where DNA is damaged.

22 Nov 2021

Scientists can read the brain activity of tiny worm to predict smells

It sounds like a party trick: scientists can now look at the brain activity of a tiny worm and tell you which chemical the animal smelled a few seconds before.

21 Nov 2021

Novel technique solves structure of the HIV capsid alone and in complex with host factors

A new technique using electron tomography and subtomogram averaging at Diamond's electron Bio-Imaging Centre (eBIC), has solved the structure of the HIV capsid alone and in complex with host factors.

21 Nov 2021

Cancer cells disarm cellular attackers by extending out nanoscale tentacles

To grow and spread, cancer cells must evade the immune system. Investigators from Brigham and Women's Hospital and MIT used the power of nanotechnology to discover a new way that cancer can disarm its would-be cellular attackers by extending out nanoscale tentacles that can reach into an immune cell and pull out its powerpack.

18 Nov 2021

Scientists use advanced microscopes to delve deeper into protein degradation process

Proteins are the building blocks of all living things. A vast amount research takes place on how these proteins are made and what they do, from enzymes that carry out chemical reactions to messengers that transmit signals between cells.

17 Nov 2021

Advanced technique reveals the ultrastructure of huntingtin inclusion bodies

Huntington's disease is a progressively debilitating brain disease that causes uncontrolled movements, psychological problems, and loss of cognition.

12 Nov 2021

Researchers identify γ-tubulin ring complex to be responsible for providing centriole stability

Centrioles are cylindrical structures involved in the generation of microtubules-;fibers inside of cells that form a network to provide structure and shape to cells and to mediate transport processes.

1 Nov 2021

Researchers untangle dopamine’s diverse functions

Among the neurotransmitters in the brain, dopamine has gained an almost mythical status. Decades of research have established its contribution to several seemingly unrelated brain functions including learning, motivation, and movement, raising the question of how a single neurotransmitter can play so many different roles.

30 Oct 2021

Atomic-level imaging of artificial proteins

Scientists have created thin, paper-like crystalline sheets using a synthetic, protein-like molecule called a polypeptoid. These nanosheets are only one molecule thick, with the molecules arranged in very specific ways.

29 Oct 2021

UCL researchers record sharpest images ever of living bacteria

The sharpest images ever of living bacteria have been recorded by UCL researchers, revealing the complex architecture of the protective layer that surrounds many bacteria and makes them harder to be killed by antibiotics.

25 Oct 2021

Study discloses molecular mechanism of oligodendrocyte myelination by osteocalcin in the CNS

Osteocalcin (OCN) is a multifunctional bone-derived hormone that modulates numerous physiological activities. OCN can cross the blood brain barrier (BBB) and thus play critical roles in neuronal and brain development.

25 Oct 2021

New method to study the nuclear pore complex directly inside cells

Context matters. It's true for many facets of life, including the tiny molecular machines that perform vital functions inside our cells.

18 Oct 2021

New algorithm provides a high-definition analysis of genome organization in single cells

Within the microscopic boundaries of a single human cell, the intricate folds and arrangements of protein and DNA bundles dictate a person's fate: which genes are expressed, which are suppressed, and -; importantly -; whether they stay healthy or develop disease.

11 Oct 2021

Using AI in biology to unravel how cells fight off invaders

Imagine the day when any tissue or organ can be repaired or the replacements personalized to the patient.

7 Oct 2021

Histology & Microscopy

X-ray laser offers new insights into how radiation damage occurs in biological tissue

Novel approach uses PSOCT to non-invasively image the depth-resolved collagen organization

The mode of action of essential proteins involved in cancer and Alzheimer´s deciphered

New technique may be a significant leap forward in the understanding of human cells

Novel method enables deeper analysis of endocrine disrupting chemicals' impact on gene expression

New "image analysis pipeline" provides insight into how disease changes the body

Cryo-EM reveals how the DNA replication machinery assembles at DNA damage sites

Scientists can read the brain activity of tiny worm to predict smells

Novel technique solves structure of the HIV capsid alone and in complex with host factors

Cancer cells disarm cellular attackers by extending out nanoscale tentacles

Scientists use advanced microscopes to delve deeper into protein degradation process

Advanced technique reveals the ultrastructure of huntingtin inclusion bodies

Researchers identify γ-tubulin ring complex to be responsible for providing centriole stability

Researchers untangle dopamine’s diverse functions

Atomic-level imaging of artificial proteins

UCL researchers record sharpest images ever of living bacteria

Study discloses molecular mechanism of oligodendrocyte myelination by osteocalcin in the CNS

New method to study the nuclear pore complex directly inside cells

New algorithm provides a high-definition analysis of genome organization in single cells

Using AI in biology to unravel how cells fight off invaders

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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