Histology & Microscopy

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New bioengineered lung model could help scientists to advance research in lung conditions

An interdisciplinary team of researchers from McMaster and SickKids are developing a cutting-edge lung model that can better respond to viruses and drug treatments, giving scientists a tool to advance research in lung conditions like COVID-19, cystic fibrosis and allergens for asthma and air pollution.

18 Aug 2021

Making the nanobody big again for Cryo-EM

Researchers describe the method that allows high-resolution structure determination of small proteins by single-particle cryo-EM using a Legobody.

17 Aug 2021

New system combines computer software and cryo-EM to determine 3D structures of RNA-only molecules

The single-stranded genetic material RNA is best known for guiding the assembly of proteins in our cells and carrying the genetic code for viruses like SARS-CoV-2 and HIV.

16 Aug 2021

Study offers molecular views on how olfactory receptors work

All senses must reckon with the richness of the world, but nothing matches the challenge faced by the olfactory system that underlies our sense of smell.

4 Aug 2021

Researchers propose new scoring system for assessing wound healing dynamics

Evaluating the efficacy of novel therapies requires the ability to monitor wound progression accurately and reproducibly over time.

21 Jul 2021

Study uncovers how force dynamics affect cells and living tissues

Researchers, led by Pere Roca-Cusachs at the Institute for Bioengineering of Catalonia (IBEC) discover how force dynamics affect cells, and living tissues. The results give an insight into the critical mechanical processes that occur in different diseases such as cancer.

16 Jul 2021

Study: 55% of university students have tried plant-based meat alternative

Fifty-five percent of Midwest university students had tried a plant-based meat alternative and attributed this choice to the enjoyment of new food, curiosity about the products, and environmental concern, according to a new study in the Journal of Nutrition Education and Behavior, published by Elsevier.

8 Jul 2021

Study examines the effectiveness of fluorescent labels used to monitor liposome accumulation in tumors

Dmitri Simberg, PhD, an associate professor in the Department of Pharmaceutical Sciences in the Skaggs School of Pharmacy and a CU Cancer Center member, has released the results of a new study of the effectiveness of different types of fluorescent labels used to monitor the accumulation of liposomes in tumors.

8 Jul 2021

NYU Abu Dhabi researchers use NMR spectroscopy to map the structure of specific nanobody

For the first time in the UAE, researchers at NYU Abu Dhabi have used nuclear magnetic resonance techniques to determine the structure of a specific nanobody, Nb23, potentially leading to a better understanding of how this small protein derived from an antibody type, found only in camelids (i.e camels, llamas, and alpacas) and sharks, can fight diseases ranging from rheumatoid arthritis, lupus and psoriasis to lymphoma and breast cancer.

2 Jul 2021

New open-source camera system captures the mouse's view of natural environment

Researchers based in Munich and Tuebingen have developed an open-source camera system that images natural habitats as they appear to rodents.

2 Jul 2021

High levels of neutrophil extracellular traps found in airways of severely ill Covid-19 patients

When researchers at Lund University in Sweden performed advanced analyses of sputum from the airways of severely ill Covid-19 patients, they found high levels of neutrophil extracellular traps (NETs).

1 Jul 2021

Novel optical device could open new avenues in advanced microscopy

What if a microscope allowed us to explore the 3D microcosm of blood vessels, nerves, and cancer cells instantaneously in virtual reality? What if it could provide views from multiple directions in real time without physically moving the specimen and worked up to 100 times faster than current technology?

1 Jul 2021

First demonstration of COVID-19-like response by an essential virus encoded protein by SARS-CoV-2 in vivo

Researchers from collaborating universities in Virginia have recently utilized transgenic mice to explore the effects of SARS-CoV-2 on associated lung injury.

30 Jun 2021

Breakthrough method for tracking mRNA molecules with fluorescence

Researchers at Chalmers University of Technology, Sweden, have succeeded in developing a method to label mRNA molecules, and thereby follow, in real time, their path through cells, using a microscope - without affecting their properties or subsequent activity.

30 Jun 2021

Researchers show how Covid-19 changes the size and stiffness of red and white blood cells

Using real-time deformability cytometry, researchers at the Max-Planck-Zentrum für Physik und Medizin in Erlangen were able to show for the first time: Covid-19 significantly changes the size and stiffness of red and white blood cells - sometimes over months.

29 Jun 2021

New insights on how an important class of immune receptors are activated

Scientists from within the Antibody and Vaccine Group at the University of Southampton have gained novel insights into how an important class of immune receptors called tumour necrosis factor receptors (TNFR) are activated.

25 Jun 2021

Structural studies of SARS-CoV-2 spike protein reveal new properties of Alpha and Beta variants

New SARS-CoV-2 variants are spreading rapidly, and there are fears that current COVID-19 vaccines won't protect against them.

25 Jun 2021

Surprising similarities found in membrane proteins of bacteria and humans

The cells of simple organisms, such as bacteria, as well as human cells are surrounded by a membrane, which fulfills various tasks including protecting the cell from stress.

24 Jun 2021

New microscopy technique reveals the cellular make-up of Wilm's tumors

A new technique to look at tumors under the microscope has revealed the cellular make-up of Wilm's tumors, a childhood kidney cancer, in unprecedented detail.