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Researchers discover PPFIA3 gene as a cause of previously unknown syndromic neurodevelopmental disorder

An international collaborative study led by postdoctoral scientist, Dr. Maimuna Paul, and child neurologist, Dr. Hsiao-Tuan Chao, an assistant professor at Baylor College, a faculty member with the Cain Pediatric Neurology Research Foundation Laboratories at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital, and an investigator at the McNair Medical Institute with The Robert and Janice McNair Foundation, recently discovered that variants in the PPFIA3 gene cause a previously unknown syndromic neurodevelopmental disorder.

4 Jan 2024

USC scientists develop first all-human brain organoids model of the cerebellum with functional neurons

In a first for USC Stem Cell scientists, the laboratory of Giorgia Quadrato, an assistant professor of stem cell biology and regenerative medicine, has pioneered a novel human brain organoid model that generates all the major cell types of the cerebellum, a hindbrain region predominantly made up of two cell types necessary for movement, cognition, and emotion: granule cells and Purkinje neurons.

4 Jan 2024

GLP-1R agonist liraglutide rapidly improves insulin sensitivity in pre-diabetics, independent of weight loss

A new study published in the journal Diabetes demonstrates that a glucagon-like peptide-1 receptor (GLP-1R) agonist, a member of a class of medication used to treat Type 2 diabetes and obesity, can lead to a rapid improvement in insulin sensitivity.

4 Jan 2024

New study highlights the work of biobank at the Colorado Center for Personalized Medicine

A new peer-reviewed study in the American Journal of Human Genetics highlights the work of the biobank at the Colorado Center for Personalized Medicine (CCPM), a world-class site for precision medicine in research and clinical care created in partnership with the University of Colorado Anschutz Medical Campus and UCHealth.

4 Jan 2024

High-resolution map of the neuroblastoma immune landscape points to new target for immunotherapy

A detailed 'atlas' of neuroblastoma tumors points to a new target for immunotherapy. Scientists from the Princess Máxima Center for Pediatric Oncology in the Netherlands mapped this childhood tumor at the level of individual cancer and immune cells.

4 Jan 2024

Gonorrhea cases surge 64% post-COVID lockdown in England, highlighting unintended STI suppression

A study analyzing data from the Genitourinary Medicine Clinic Activity Dataset in England shows a 64% increase in gonorrhea diagnoses following the relaxation of COVID-19 restrictions, despite only a 5.6% increase in STI testing, suggesting that social distancing may have suppressed STI transmission.

4 Jan 2024

Metabolically armored CAR-T cells demonstrate lasting efficacy against solid tumors

At EPFL's School of Engineering, Professor Li Tang's Laboratory of Biomaterials for Immunoengineering has made significant strides in cancer treatment research.

4 Jan 2024

Researchers harness the power of AI to enhance assessment of the heart's right ventricle

In a milestone study, researchers from the Icahn School of Medicine at Mount Sinai have harnessed the power of artificial intelligence (AI) to enhance the assessment of the heart's right ventricle, which sends blood to the lungs.

4 Jan 2024

Study unveils novel method for visualizing muscle coordination and assessing fatigue

Surface electromyography (sEMG) is a traditional method used to measure the electrical activity of muscles during physical activity.

4 Jan 2024

Prevention of post-menopausal osteoporosis in rats by sesame oil

Study demonstrates that daily supplementation with sesame oil in a rat model effectively prevents post-menopausal osteoporosis by maintaining serum estrogen and aromatase levels, suggesting its potential as a safer alternative to hormone replacement therapy.

4 Jan 2024

Computerized cognitive training shows promise in enhancing memory for dementia patients

Study systematically reviews and meta-analyzes the impact of computerized cognitive training (CCT) on memory functions in patients with mild cognitive impairment or dementia, highlighting the benefits of both supervised and unsupervised CCT.

4 Jan 2024

Revolutionary RNA-based switch offers new control over gene expression in mammalian cells

Researchers developed an RNA-based switch, the pA regulator system, to control gene expression in mammalian cells by modulating synthetic polyA signal cleavage, offering a novel approach for gene therapy applications.

4 Jan 2024

AI model predicts future spread of SARS-CoV-2 variants using genomic data

Researchers developed an AI-based model to predict the spread of new SARS-CoV-2 variants, analyzing nine million genomic sequences across 30 countries and incorporating factors like vaccination rates and non-pharmaceutical interventions.

4 Jan 2024

Imbalances in folic acid and vitamin B12 can alter brain development in mice

Folate is a B vitamin and a necessary nutrient to prevent neural tube defects, such as spina bifida. Folic acid, a synthetic form of folate, has been added to vitamins, breakfast cereals and other products in the U.S. and more than 80 other countries to ensure pregnant women get adequate amounts.

4 Jan 2024

Gut microbes revealed as key players in liver disease solutions

In the editorial published on 4 September 2023, in the "gut-liver axis" special issue of the journal Hepatobiliary & Pancreatic Diseases International, Dr. Jian-Gao Fan and Dr. Lu Jiang from Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine provided a comprehensive elucidation of the pivotal role of gut microbiota in various liver diseases.

4 Jan 2024

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, Sanford Burnham Prebys and Rutgers University have uncovered possible novel functions for various autophagy genes, which may control different forms of disposal including misfolded proteins-;and ultimately affect aging.

4 Jan 2024

CLivD score shows promise in early detection of steatotic liver disease and advanced fibrosis

Chronic liver disease, a growing threat to global health, often progresses silently in its early stages.

4 Jan 2024

Study identifies mitochondrial dysfunction as cause of long-COVID fatigue

Researchers from Amsterdam UMC and Vrije Universiteit Amsterdam (VU) have discovered that the persistent fatigue in patients with long-COVID has a biological cause, namely mitochondria in muscle cells that produce less energy than in healthy patients.

4 Jan 2024

Researchers develop peptide to target "chaotic" MYC protein in 75% of cancers

Meet MYC, the shapeless protein responsible for making the majority of human cancer cases worse.

4 Jan 2024

Salk scientists map brain circuit triggering the crippling panic attacks

Overwhelming fear, sweaty palms, shortness of breath, rapid heart rate-;these are the symptoms of a panic attack, which people with panic disorder have frequently and unexpectedly.

4 Jan 2024

Medical Science News

Researchers discover PPFIA3 gene as a cause of previously unknown syndromic neurodevelopmental disorder

USC scientists develop first all-human brain organoids model of the cerebellum with functional neurons

GLP-1R agonist liraglutide rapidly improves insulin sensitivity in pre-diabetics, independent of weight loss

New study highlights the work of biobank at the Colorado Center for Personalized Medicine

High-resolution map of the neuroblastoma immune landscape points to new target for immunotherapy

Gonorrhea cases surge 64% post-COVID lockdown in England, highlighting unintended STI suppression

Metabolically armored CAR-T cells demonstrate lasting efficacy against solid tumors

Researchers harness the power of AI to enhance assessment of the heart's right ventricle

Study unveils novel method for visualizing muscle coordination and assessing fatigue

Prevention of post-menopausal osteoporosis in rats by sesame oil

Computerized cognitive training shows promise in enhancing memory for dementia patients

Revolutionary RNA-based switch offers new control over gene expression in mammalian cells

AI model predicts future spread of SARS-CoV-2 variants using genomic data

Imbalances in folic acid and vitamin B12 can alter brain development in mice

Gut microbes revealed as key players in liver disease solutions

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

CLivD score shows promise in early detection of steatotic liver disease and advanced fibrosis

Study identifies mitochondrial dysfunction as cause of long-COVID fatigue

Researchers develop peptide to target "chaotic" MYC protein in 75% of cancers

Salk scientists map brain circuit triggering the crippling panic attacks

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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