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'Phenotype switching' helps bacteria lie dormant inside host cells and become a reservoir for relapsing infections

A new study into Staphylococcus aureus, the bacterium which is responsible for severe chronic infections worldwide, reveals how the bacteria have developed a strategy of hiding within host cells to escape the immune system as well as many antibacterial treatments. The research, published by EMBO Molecular Medicine, demonstrates how 'phenotype switching' enables bacteria to adapt to their environmental conditions, lie dormant inside host cells and become a reservoir for relapsing infections.

27 Jan 2011

First three-dimensional projectome map of intact brain

It would be hard to understand how a city is organized without knowledge of the course of all of its streets. Scientists confront the same problem when trying to understand the functioning of the brain. In the case of vertebrates, we only have fragmentary knowledge of which nerve cells send their connections, so-called axons, into certain regions of the brain.

27 Jan 2011

Caffeine could decrease cost of lentiviral production

Give caffeine to cells engineered to produce viruses used for gene therapy and the cells can generate 3- to 8-times more virus, according to a paper published in Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc.

27 Jan 2011

Molecular mechanism in nerve fibers ensures rapid conductance of nervous system impulses

New research from the University of North Carolina at Chapel Hill School of Medicine describes a key molecular mechanism in nerve fibers that ensures the rapid conductance of nervous system impulses.

27 Jan 2011

NuGEN expands NGS utility for microbial transcriptome analysis with Ovation Prokaryotic RNA-Seq System

NuGEN Technologies, a leader in genomics sample preparation, expands the utility of next-generation sequencing for the analysis of microbial species and microbiome samples with its Ovation Prokaryotic RNA-Seq System.

27 Jan 2011

AB Science initiates recruitment in masitinib phase 3 study in severe persistent asthma

AB Science SA, a pharmaceutical company specialising in the research, development and commercialisation of protein kinase inhibitors (PKIs), announced today the recruitment of the first patient in the phase 3 study evaluating masitinib in severe persistent asthma.

27 Jan 2011

How estrogen decreases risk and delays onset and progression of Alzheimer's disease

An influential article in the journal Progress in Neurobiology provided one of the first comprehensive reviews of how estrogen potentially can protect against Alzheimer's disease and other neurological disorders.

27 Jan 2011

Study: Removal of B lymphocytes can reverse aging process

Researchers at the Technion-Israel Institute of Technology have discovered a way to reverse the aging process by removing old B lymphocytes from old mice, and forcing the production of young, potent cells to replace them.

27 Jan 2011

Triggering CD45 molecule blocks early development of AD

A new target for the prevention of adverse immune responses identified as factors in the development of Alzheimer's disease (AD) has been discovered by researchers at the University of South Florida's Department of Psychiatry and the Center of Excellence for Aging and Brain Repair.

27 Jan 2011

Pfenex receives $3.1 million SAIC sub-contract to develop malaria antigen

Pfenex today announced that Science Applications International Corporation has awarded Pfenex a sub-contract valued at $3.1 million to help develop a robust, scalable, cGMP ready production process for large scale production of full length Circumsporozoite protein from Plasmodium falciparum.

27 Jan 2011

Researchers discover new sensory neurons that mediate BP and metabolism regulation in liver

For 60 years, scientists have puzzled over the possibility of a hepatic osmoreceptor that influences blood pressure regulation. Now, researchers of the Max Delbr-ck Center for Molecular Medicine Berlin-Buch, the Experimental and Clinical Research Center of the MDC and Charit- and the Hannover Medical School appear to have made a breakthrough discovery.

27 Jan 2011

Teen brains react with erratic excitement during reward-driven tasks

University of Pittsburgh researchers have recorded neuron activity in adolescent rat brains that could reveal the biological root of the teenage propensity to consider rewards over consequences and explain why adolescents are more vulnerable to drug addiction, behavioral disorders, and other psychological ills.

27 Jan 2011

Targeting UROD enzyme boosts effects of radiotherapy and chemotherapy in head, neck tumors

Cancer researchers at Princess Margaret Hospital (PMH) have discovered that targeting an enzyme called Uroporphyrinogen Decarboxylase (UROD) can sensitize diseased tissue to radiation and chemotherapy, which could mean fewer side effects for individuals with head and neck cancer.

27 Jan 2011

MGH investigators develop novel system to deliver growth factors to chronic wounds

Massachusetts General Hospital investigators have developed a novel system for delivery of growth factors to chronic wounds such as pressure sores and diabetic foot ulcers.

27 Jan 2011

Elimination of glucagon action may help convert Type 1 diabetes into non-insulin-dependent disorder

Type 1 diabetes could be converted to an asymptomatic, non-insulin-dependent disorder by eliminating the actions of a specific hormone, new findings by UT Southwestern Medical Center researchers suggest.

27 Jan 2011

Potential therapy to enhance memory and prevent loss of long-term memory

Researchers from Mount Sinai School of Medicine have identified a therapy that may enhance memory and prevent the loss of long-term memory. The research is published in the January 27th issue of Nature.

27 Jan 2011

Researchers find food-borne bacteria can cause difficult-to-treat heart infections

Researchers at the University of Illinois at Chicago College of Medicine have found that particular strains of a food-borne bacteria are able to invade the heart, leading to serious and difficult-to-treat heart infections.

27 Jan 2011

Researchers develop anti-HIV gene therapy for rendering T-cells resistant to infection

An innovative genetic strategy for rendering T-cells resistant to HIV infection without affecting their normal growth and activity is described in a paper published in Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc. The paper is available free online.

26 Jan 2011

Spine surgeon successfully treated with RNL Bio's stem cell therapy for Autoimmune Arthritis

RNL BIO CO., LTD, a leading biopharmaceutical company specialized in adult stem cell therapeutics, announced on January 21, 2011 another successful patient report utilizing stem cell therapy on a leading US orthopedic spine surgeon who suffered from Autoimmune Arthritis.

26 Jan 2011

Evaluating patients for genetic variations impacts adherence to antiviral therapy

In two recent studies, researchers have identified two functional variants in the inosine triphosphatase (ITPA) gene that protect patients with hepatitis C virus (HCV) against anemia brought on by antiviral treatment. The ability to identify those patients protected against treatment-induced anemia will ensure completion of antiviral therapy and successful elimination of the virus.

25 Jan 2011

Medical Science News

'Phenotype switching' helps bacteria lie dormant inside host cells and become a reservoir for relapsing infections

First three-dimensional projectome map of intact brain

Caffeine could decrease cost of lentiviral production

Molecular mechanism in nerve fibers ensures rapid conductance of nervous system impulses

NuGEN expands NGS utility for microbial transcriptome analysis with Ovation Prokaryotic RNA-Seq System

AB Science initiates recruitment in masitinib phase 3 study in severe persistent asthma

How estrogen decreases risk and delays onset and progression of Alzheimer's disease

Study: Removal of B lymphocytes can reverse aging process

Triggering CD45 molecule blocks early development of AD

Pfenex receives $3.1 million SAIC sub-contract to develop malaria antigen

Researchers discover new sensory neurons that mediate BP and metabolism regulation in liver

Teen brains react with erratic excitement during reward-driven tasks

Targeting UROD enzyme boosts effects of radiotherapy and chemotherapy in head, neck tumors

MGH investigators develop novel system to deliver growth factors to chronic wounds

Elimination of glucagon action may help convert Type 1 diabetes into non-insulin-dependent disorder

Potential therapy to enhance memory and prevent loss of long-term memory

Researchers find food-borne bacteria can cause difficult-to-treat heart infections

Researchers develop anti-HIV gene therapy for rendering T-cells resistant to infection

Spine surgeon successfully treated with RNL Bio's stem cell therapy for Autoimmune Arthritis

Evaluating patients for genetic variations impacts adherence to antiviral therapy

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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