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Tobacco-free cigarettes may be more carcinogenic than tobacco products: Study

Using the same technique they developed to document the harmful effects of tobacco products, a team of researchers found that cigarettes made without tobacco or nicotine may be more carcinogenic because they actually induce more extensive DNA damage than tobacco products.

13 May 2010

NARSAD honours UNC's Patrick Sullivan with 2010 Distinguished Investigator Award

Patrick Sullivan, MD has received a 2010 Distinguished Investigator Award from NARSAD for a comparison of genetics in schizophrenia and bipolar disorder.

13 May 2010

Research sheds light on prenatal heart formation, chromosome 22q.11 deletion syndrome

Researchers studying the common genetic disorder chromosome 22q.11 deletion syndrome have identified key proteins that act together to regulate early embryonic development. One protein is essential to life; in animal studies, embryos without the protein do not survive past the first few days of gestation.

13 May 2010

Tripos releases SYBYL-X 1.1 molecular modeling suite

Tripos®, a leading provider of drug discovery informatics products and services, today announced the release and general availability of SYBYL-X Version 1.1. This new release focuses on enhancing research productivity for scientists in the pharmaceutical, agrochemical, flavors and fragrances, and related industries, featuring faster navigation, new menus and toolbars, and new ways to approach life science molecular discovery projects. Previous SYBYL versions have been the benchmark for the industry in molecular modeling, and customers using this new, next generation version have given it high marks.

13 May 2010

Regeneron Pharmaceuticals provides update on REGN727, REGN475 antibody product candidates

Regeneron Pharmaceuticals, Inc. (REGN) provided an update on two antibody product candidates in its pipeline and scheduled its first Investor Day to be held in New York City on July 15, 2010. Both product candidates, REGN727 (SAR236553) and, REGN475 (SAR164877) are being developed with sanofi-aventis under a global, strategic collaboration to discover, develop, and commercialize fully human antibodies.

13 May 2010

Tracking genes in infant's intestine helps compare early development of breast-fed and formula-fed babies

Is breast milk so different from infant formula? The ability to track which genes are operating in an infant's intestine has allowed University of Illinois scientists to compare the early development of breast-fed and formula-fed babies. They say the difference is very real.

13 May 2010

Microbiologists identify potential target in cattle to prevent E. coli strain

Microbiologists at UT Southwestern Medical Center, working with the Department of Agriculture, have identified a potential target in cattle that could be exploited to help prevent outbreaks of food-borne illnesses caused by a nasty strain of Escherichia coli.

13 May 2010

China Biologic subsidiary Shandong Taibang receives approval to build two new plasma stations

China Biologic Products, Inc., a leading plasma-based biopharmaceutical company in China, today announced that its majority-owned subsidiary, Shandong Taibang Biological Products Co. Ltd., has been approved by the Shandong Province Health Department to build two new plasma stations.

12 May 2010

FDA approves Aeterna Zentaris' AEZS-108 IND for bladder cancer

Aeterna Zentaris Inc., a late-stage drug development company specialized in oncology and endocrine therapy, today announced that the U.S. Food and Drug Administration (FDA) has approved the Company's Investigational New Drug (IND) application for its doxorubicin targeted conjugate compound, AEZS-108, in luteinizing hormone releasing hormone (LHRH) receptor positive urothelial (bladder) cancer.

12 May 2010

Genetic variations do not improve ability to predict risk of AD: Study

Although genome-wide analysis identified two genetic variations associated with Alzheimer disease, these variations did not improve the ability to predict the risk of AD, according to a study in the May 12 issue of JAMA.

12 May 2010

Marriage raises life expectancy

Marriage is more beneficial for men than for women - at least for those who want a long life. Previous studies have shown that men with younger wives live longer. While it had long been assumed that women with younger husbands also live longer, in a new study Sven Drefahl from the Max Planck Institute for Demographic Research (MPIDR) in Rostock, Germany, has shown that this is not the case. Instead, the greater the age difference from the husband, the lower the wife's life expectancy.

12 May 2010

Sanford-Burnham Scientific Symposium provides wealth of information on microRNAs, RNAi

Investigators from around the country came to Sanford-Burnham Medical Research Institute (Sanford-Burnham) on Friday, May 7, to share their knowledge of the burgeoning young field of microRNAs. These small non-coding nucleic acids turn off proteins and have been implicated in viral infection, cancer, cardiovascular disease, HIV and numerous other conditions.

12 May 2010

Key mechanisms for delivery of LNP-encapsulated siRNAs to the liver

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today the publication of pre-clinical research in the journal Molecular Therapy revealing key mechanisms related to the systemic delivery of RNAi therapeutics using lipid nanoparticles (LNPs).

12 May 2010

Mutations in STRAD-alpha gene can cause PMSE syndrome in Amish children: Penn researchers

So often the rare informs the common. Penn researchers investigating a regulatory protein involved in a rare genetic disease have shown that it may be related to epileptic and autistic symptoms in other more common neurological disorders.

12 May 2010

New approach to harness and modulate enzyme activity

An Arizona State University graduate student, Jinglin Fu, in collaboration with Biodesign Institute researchers Neal Woodbury and Stephen Albert Johnston, has pioneered a technique that improves on scientists' ability to harness and modulate enzyme activity.

12 May 2010

Giardia's surface proteins may work as vaccines to help prevent infections: Research scholar

The intestinal parasite Giardia lamblia changes outfits nearly as often as a fashion model on a Parisian runway. With more than 200 protein coats in its molecular wardrobe, this troublesome creature-the cause of innumerable cases of diarrheal infections each year-can change its appearance from one instant to the next, throwing the body's immune cells off track.

12 May 2010

Genetic tests represent future of cancer care for women

Important progress is being made in women's health through the use of genetic tests, particularly those that help women detect and treat cancer.

12 May 2010

Mutation causing light chain amyloidosis identified

Light chain amyloidosis, a deadly protein misfolding disease, is caused by multiple mutations in cells that are intended to protect the body. Instead, the mutations send misfolded bundles of proteins through the bloodstream, potentially destroying the heart, kidneys, liver or other organs. Mayo Clinic researchers have identified one of these mutations and have shown that the molecule's shifting position is as important as its unique shape. The findings appear in the current issue of the journal Structure.

12 May 2010

Benefits outweigh risks in myeloablative therapy for children with high-risk neuroblastoma

Neuroblastoma is among the most common of childhood cancers and fortunately, some children will get better spontaneously. Yet for children with high-risk disease the outlook is poor: more than half will relapse despite chemotherapy.

12 May 2010

BioGenes study documents insufficient sensitivity of ELISA-based generic HCP assay

BioGenes GmbH, a supplier of GMP-compliant immunoassays and antibodies, completed a study that documents the insufficient sensitivity of an ELISA-based generic host cell protein assay. The results confirm the observation of several contract manufacturers that generic HCP assays are only of limited use for detection of HCPs during manufacturing processes.

12 May 2010

Medical Science News

Tobacco-free cigarettes may be more carcinogenic than tobacco products: Study

NARSAD honours UNC's Patrick Sullivan with 2010 Distinguished Investigator Award

Research sheds light on prenatal heart formation, chromosome 22q.11 deletion syndrome

Tripos releases SYBYL-X 1.1 molecular modeling suite

Regeneron Pharmaceuticals provides update on REGN727, REGN475 antibody product candidates

Tracking genes in infant's intestine helps compare early development of breast-fed and formula-fed babies

Microbiologists identify potential target in cattle to prevent E. coli strain

China Biologic subsidiary Shandong Taibang receives approval to build two new plasma stations

FDA approves Aeterna Zentaris' AEZS-108 IND for bladder cancer

Genetic variations do not improve ability to predict risk of AD: Study

Marriage raises life expectancy

Sanford-Burnham Scientific Symposium provides wealth of information on microRNAs, RNAi

Key mechanisms for delivery of LNP-encapsulated siRNAs to the liver

Mutations in STRAD-alpha gene can cause PMSE syndrome in Amish children: Penn researchers

New approach to harness and modulate enzyme activity

Giardia's surface proteins may work as vaccines to help prevent infections: Research scholar

Genetic tests represent future of cancer care for women

Mutation causing light chain amyloidosis identified

Benefits outweigh risks in myeloablative therapy for children with high-risk neuroblastoma

BioGenes study documents insufficient sensitivity of ELISA-based generic HCP assay

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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